Developmental fMRI Study of Alcohol Use in Adolescence

青春期饮酒的发育功能磁共振成像研究

基本信息

批准号：
8536527
负责人：
DIANA H FISHBEIN
金额：
$ 4.93万
依托单位：
RESEARCH TRIANGLE INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-20 至 2014-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8536527
关键词：
13 year old Accounting Adolescence Adolescent Adult Adverse effects Affective Aggressive behavior Alcohol abuse Alcohol consumption Alcoholism Alcohols Amygdaloid structure Anterior Area Behavioral Belief Brain Characteristics Cognitive Data Collection Decision Making Deltastab Development Dose Drug abuse Drug usage Emotional Emotions Ensure Exhibits Exposure to Family Frequencies Functional Magnetic Resonance Imaging Grant Growth Heavy Drinking Illicit Drugs Impairment Insula of Reil Intervention Investigation Lead Longitudinal Studies Measures Mediator of activation protein Modeling Nature Neurocognitive Neurodevelopmental Deficit Neurons Neurotoxins Pathway interactions Pattern Pharmaceutical Preparations Prefrontal Cortex Process Prospective Studies Recording of previous events Regulation Research Risk Risk Factors Sampling Self-control as a personality trait Social Behavior Social support Socioeconomic Status Structure Synapses Tobacco Tobacco use Ventral Striatum Youth adolescents with alcohol use disorders alcohol effect alcohol expectancy alcohol misuse alcohol response alcohol use disorder alcohol use initiation binge drinking blood oxygen level dependent chronic alcohol ingestion cognitive function cohesion cohort drinking early alcohol use emerging adult falls inattention interest neurodevelopment parental monitoring peer influence programs prospective relating to nervous system response scaffold skills therapy design underage drinking white matter

项目摘要

DESCRIPTION (provided by applicant): Alcohol use is primarily initiated during vulnerable developmental years when white matter tracts arborize within the prefrontal cortex (PFC), and between the PFC, anterior cingulate, ventral striatum and limbic (affective) structures, and significant synaptic pruning occurs. This neuronal fine-tuning establishes the scaffolding for the progressive neurodevelopment of executive cognitive and emotional regulatory functions that are critical for emotional and behavioral self-control. The vulnerability of this process in adolescence may explain findings of impairments in adolescents with alcohol use problems and in adults with a history of chronic alcohol use that began in adolescence; early alcohol use and heavy episodic drinking in adolescence may lead to long-term neural and behavioral developmental consequences. Also unknown is whether some of the neurodevelopmental delays and deficits associated with alcohol use actually predate use, thereby increasing propensity to misuse alcohol. And as precursor conditions, they may be particularly susceptible to further damage in response to the continued use of alcohol. No study to date has attempted to track neurodevelopmental precursors and the changes in these processes resulting from varying levels of alcohol use throughout adolescence. The proposed 5-year prospective longitudinal fMRI study seeks to identify functional neuroanatomical substrates of neurodevelopmental liability to initiate and escalate alcohol use and chart the progressive nature of neurocognitive change as a consequence of varying levels of alcohol use during adolescence. This study will also, in effect, isolate the potential dose-dependent neurodevelopmental consequences of alcohol use from precursor conditions. Alcohol and drug-"na¿ve" 11- to 13-year-olds will be prescreened for characteristics predictive of alcohol problems to ensure that a sufficient number of youth (final n=154) will exhibit initiation and varying levels of escalation of drinking during the course of the study. Three 16 month waves of data collection will be conducted. Neurocognitive markers of developmental deficits and delays (e.g., inattention, risky decision making, emotional dysregulation) have been associated with alcohol, tobacco, and other drug use in previous research conducted by the study team and others, thus laying the groundwork for a longitudinal investigation of neurocognitive vulnerability factors in initiation and escalation of alcohol use and its potential effects (e.g., Brown & Tapert, 2004; Fishbein et al., 2005a,b; Giancola et al., 1996; Sher et al., 1997; Tarter et al., 2004; Zeigler et al., 2005). In all analyses, adjustments will be made for concurrent use of tobacco and other drugs, SES, IQ, parental alcohol and drug abuse, and other relevant covariates, such as aggression, alcohol expectancies, normative beliefs about alcohol, social supports, and deviance. Overall, the proposed study has implications for understanding underlying mechanisms in the development of maladaptive social behaviors that increase risk for alcohol initiation and escalation and suggest specific strategies for interventions that strengthen these functions, thereby altering the developmental trajectory for at-risk adolescents.

描述（由申请人提供）：酒精的使用主要是在脆弱的发育时期开始的，当时白质束在前额皮质（PFC）内以及在 PFC、前扣带回、腹侧纹状体和边缘（情感）结构之间形成树状结构，并且有显着的突触修剪这种神经微调为执行认知和情绪调节功能的渐进神经发育奠定了基础，这对于情绪和行为自我控制至关重要。青春期的过程可能可以解释有饮酒问题的青少年和有从青春期开始的长期饮酒史的成年人的损伤发现；青春期早期饮酒和大量饮酒可能会导致长期的神经和行为发育后果。同样未知的是，与饮酒相关的一些神经发育迟缓和缺陷是否实际上早于饮酒，从而增加了滥用酒精的倾向，并且作为先兆条件，它们可能特别容易因持续饮酒而受到进一步损害。迄今为止试图追踪神经发育前兆以及整个青春期不同程度的饮酒所导致的这些过程的变化。拟议的为期 5 年的前瞻性纵向功能磁共振成像研究旨在确定神经发育倾向的功能性神经解剖学基础，以启动和升级饮酒并绘制渐进图。这项研究实际上还将酒精使用与先兆条件分离出潜在的剂量依赖性神经发育后果。将对 11 至 13 岁的青少年进行预筛查，以了解可预测酒精问题的特征，以确保有足够数量的青少年（最终 n = 154）在研究过程中表现出饮酒的开始和不同程度的升级。将进行三轮为期 16 个月的数据收集，以表明发育缺陷和迟缓（例如注意力不集中、做出危险决策、情绪失调）与酒精、烟草和其他药物的使用有关。研究小组和其他人之前进行的研究，从而为纵向研究酒精使用的开始和升级中的神经认知脆弱因素及其潜在影响奠定了基础（例如，Brown & Tapert，2004；Fishbein 等，2005a， b；Giancola 等人，1996；Tarter 等人，2004； 2005），在所有分析中，将对同时使用烟草和其他药物、社会经济地位、智商、父母酒精和药物滥用以及其他相关协变量（例如攻击性、酒精预期、关于酒精的规范信念、社会支持）进行调整。总体而言，拟议的研究对于理解增加酗酒和酗酒风险的不良社会行为发展的潜在机制具有重要意义，并提出了加强这些功能的具体干预策略，从而改变了高危人群的发展轨迹。青少年。