Developmental fMRI Study of Alcohol Use in Adolescence

青春期饮酒的发育功能磁共振成像研究

• 批准号: 8500083
• 负责人: DIANA H FISHBEIN
• 金额: $ 63.03万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-20 至 2014-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8500083
• 关键词: 13 year old; Accounting; Adolescence; Adolescent; Adult; Adverse effects; Affective; Aggressive behavior; Alcohol abuse; Alcohol consumption; Alcoholism; Alcohols; Amygdaloid structure; Anterior; Area; Behavioral; Belief; Brain; Characteristics; Cognitive; Data Collection; Decision Making; Deltastab; Development; Dose; Drug abuse; Drug usage; Emotional; Emotions; Ensure; Exhibits; Exposure to; Family; Frequencies; Functional Magnetic Resonance Imaging; Grant; Growth; Heavy Drinking; Illicit Drugs; Impairment; Insula of Reil; Intervention; Investigation; Lead; Longitudinal Studies; Measures; Mediator of activation protein; Modeling; Nature; Neurocognitive; Neurodevelopmental Deficit; Neurons; Neurotoxins; Pathway interactions; Pattern; Pharmaceutical Preparations; Prefrontal Cortex; Process; Prospective Studies; Recording of previous events; Regulation; Research; Risk; Risk Factors; Sampling; Self-control as a personality trait; Social Behavior; Social support; Socioeconomic Status; Structure; Synapses; Tobacco; Tobacco use; Ventral Striatum; Youth; adolescents with alcohol use disorders; alcohol effect; alcohol expectancy; alcohol misuse; alcohol response; alcohol use disorder; alcohol use initiation; binge drinking; blood oxygen level dependent; chronic alcohol ingestion; cognitive function; cohesion; cohort; drinking; early alcohol use; emerging adult; falls; inattention; interest; neurodevelopment; parental monitoring; peer influence; programs; prospective; relating to nervous system; response; scaffold; skills; therapy design; underage drinking; white matter

DESCRIPTION (provided by applicant): Alcohol use is primarily initiated during vulnerable developmental years when white matter tracts arborize within the prefrontal cortex (PFC), and between the PFC, anterior cingulate, ventral striatum and limbic (affective) structures, and significant synaptic pruning occurs. This neuronal fine-tuning establishes the scaffolding for the progressive neurodevelopment of executive cognitive and emotional regulatory functions that are critical for emotional and behavioral self-control. The vulnerability of this process in adolescence may explain findings of impairments in adolescents with alcohol use problems and in adults with a history of chronic alcohol use that began in adolescence; early alcohol use and heavy episodic drinking in adolescence may lead to long-term neural and behavioral developmental consequences. Also unknown is whether some of the neurodevelopmental delays and deficits associated with alcohol use actually predate use, thereby increasing propensity to misuse alcohol. And as precursor conditions, they may be particularly susceptible to further damage in response to the continued use of alcohol. No study to date has attempted to track neurodevelopmental precursors and the changes in these processes resulting from varying levels of alcohol use throughout adolescence. The proposed 5-year prospective longitudinal fMRI study seeks to identify functional neuroanatomical substrates of neurodevelopmental liability to initiate and escalate alcohol use and chart the progressive nature of neurocognitive change as a consequence of varying levels of alcohol use during adolescence. This study will also, in effect, isolate the potential dose-dependent neurodevelopmental consequences of alcohol use from precursor conditions. Alcohol and drug-"na¿ve" 11- to 13-year-olds will be prescreened for characteristics predictive of alcohol problems to ensure that a sufficient number of youth (final n=154) will exhibit initiation and varying levels of escalation of drinking during the course of the study. Three 16 month waves of data collection will be conducted. Neurocognitive markers of developmental deficits and delays (e.g., inattention, risky decision making, emotional dysregulation) have been associated with alcohol, tobacco, and other drug use in previous research conducted by the study team and others, thus laying the groundwork for a longitudinal investigation of neurocognitive vulnerability factors in initiation and escalation of alcohol use and its potential effects (e.g., Brown & Tapert, 2004; Fishbein et al., 2005a,b; Giancola et al., 1996; Sher et al., 1997; Tarter et al., 2004; Zeigler et al., 2005). In all analyses, adjustments will be made for concurrent use of tobacco and other drugs, SES, IQ, parental alcohol and drug abuse, and other relevant covariates, such as aggression, alcohol expectancies, normative beliefs about alcohol, social supports, and deviance. Overall, the proposed study has implications for understanding underlying mechanisms in the development of maladaptive social behaviors that increase risk for alcohol initiation and escalation and suggest specific strategies for interventions that strengthen these functions, thereby altering the developmental trajectory for at-risk adolescents.

描述（由适用提供）：饮酒主要是在脆弱的发育年份开始的，当时白质区域内的额叶皮层（PFC）在PFC，前扣带回，腹侧纹状体和边缘（情感）（情感）结构以及大量的突触pruning发生之间。这种神经元的微调为执行认知和情感调节功能的渐进性神经发育建立了脚手架，这对于情感和行为自我控制至关重要。在青少年中，这一过程的脆弱性可以解释饮酒问题的青少年和有慢性酒精饮酒史的青少年损害的发现。早期的饮酒和青少年的大量饮酒可能会导致长期中性和行为发展后果。同样未知的是，与饮酒相关的一些神经发育延迟和实际使用的缺陷是否会越来越多地使用，从而增加了失去饮酒的希望。作为前体的条件，由于继续使用酒精，它们可能特别容易受到进一步损害。迄今为止，还没有研究试图跟踪神经发育前体和这些过程中由于整个青少年的饮酒水平而导致的这些过程的变化。拟议的5年前瞻性FMRI研究旨在识别神经发育责任的功能性神经解剖学基质，以启动和升级饮酒，并绘制神经认知变化的渐进性，这是由于青少年期间酒精使用水平的不同水平而导致的。实际上，这项研究还将隔离饮酒对前体条件的潜在剂量依赖性神经发育后果。预测酒精和药物 - “na¿将进行三个16个月的数据收集浪潮。发育不足和延误的神经认知标志物（例如，不注意，危险的决策，情绪失调）与研究团队和其他人进行的先前研究中的先前研究中有关，因此在牛皮度研究中对神经认知脆弱性的长期研究奠定了基础，从而为旋转和逃生的启动和逃生而造成了2004年的效果和逃生的效果。 Fishbein等人，2005a，b;在所有分析中，都将进行调整，以同时使用烟草和其他药物，SES，智商，父母酒精和药物滥用以及其他相关的协变量，例如侵略性，酒精期望，对酒精，社会支持和偏差的正常信念。总体而言，拟议的研究对理解不良适应性社会行为发展的潜在机制具有影响，这些机制增加了酒精饮酒的风险和升级的风险，并提出了增强这些功能的干预措施的具体策略，从而改变了高危青少年的发展轨迹。