Advancing Transdisciplinary Translation for Prevention of High-Risk Behaviors

推进跨学科翻译以预防高风险行为

• 批准号: 8205223
• 负责人: DIANA H FISHBEIN
• 金额: $ 5万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-26 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8205223
• 关键词: Address; Aggressive behavior; Applications Grants; Back; Basic Science; Behavioral; Behavioral Sciences; Chemistry; Child; Clinical Trials; Collaborations; Data Set; Development; Drug abuse; Education; Engineering; Environmental Exposure; Epidemiology; Epigenetic Process; Ethical Issues; Etiology; Funding; Gambling; Generations; Genetic; Goals; Health Policy; Individual; Individual Differences; Intervention; Intervention Studies; Journals; Knowledge; Light; Maps; Marketing; Mediator of activation protein; Mental Health; Methodology; Methods; Monograph; Neurobiology; Neurosciences; Outcome; Participant; Perception; Physics; Pilot Projects; Policies; Policy Developments; Prevention; Prevention Research; Preventive Intervention; Problem behavior; Process; Progress Reports; Public Health; Publications; Publishing; Research; Research Infrastructure; Research Personnel; Research Priority; Risk; Risk Behaviors; Risk Factors; Risk Marker; Science; Science of genetics; Social Sciences; Solutions; Source; Surveys; Systems Biology; Techniques; Thinking; Translational Research; Translations; Work; career; design; developmental psychology; follow-up; forging; genetic epidemiology; high risk behavior; high-risk behavior prevention; innovation; meetings; neurogenetics; novel; prevent; programs; prospective; psychosocial; response; social; symposium; theories

DESCRIPTION (provided by applicant): Scientific Meetings to Advance Transdisciplinary Translation for Prevention of High-Risk Behaviors Several cross-cutting, forward-thinking investigators on the leading edge of both the social (geospatial mapping, contextual behavioral science, developmental psychology, education, social media) and basic sciences (genetic epidemiology, epigenetics, neuroscience, chemistry) have recently made notable advances in identifying factors that influence emergence of high-risk behaviors. This information has potentially significant implications for the prevention of high-risk behaviors, given that etiological social and neurobiological risk factors may also operate as moderators and/or mediators of intervention outcomes. Transfer and application of this knowledge from the basic to the prevention sciences and back again is, however, lacking. This transfer is particularly needed to understand differences in individual response to interventions to prevent high-risk behaviors and develop new interventions tailored for an individual's risk factors. We propose to use the R13 mechanism to hold two round-table meetings that convene a core of 60 relevant experts and advisors to "connect the dots" across the translational spectrum by identifying pressing scientific questions in risk behavior prevention research, as well as the collaborations and capabilities needed to address them. These meetings are designed to facilitate the relevance, operational feasibility, and utility of a transdisciplinary translational program of research to gain a better understanding of the mechanisms underlying individual differences in intervention responsivity. Meetings will promote a cross-disciplinary integration of theoretical perspectives and empirical methods to: a) identify high priority scientific questions yet to be addressed in the prevention sciences that may be informed by a new generation of research suggesting that neurogenetic mechanisms correlate and interact with environmental conditions to promote or interfere with behavioral change in response to interventions; b) conceive of novel psychosocial and technological preventive intervention approaches and policy developments that incorporate transdisciplinary scientific findings, c) discuss an educational agenda for early career researchers to move into translational prevention; d) identify potentialities for new collaborations that will facilitate the advancement of a Translational Network for prevention research, e) conduct a survey of participants for their perceptions before and after the conferences regarding team science, needs for translational competencies, and market analysis; f) address ethical issues arising from inclusion of genetic and neurobiological markers of risk for behavioral problems, g) publish an open-access monograph of the proceedings; h) publish two special journal editions authored by a subset of attendees who will reanalyze their clinical trials datasets using state-of-the-art statistical techniques to elucidate mechanistic effects of their interventions, and report progress and preliminary findings from new collaborations forged during the meetings. PUBLIC HEALTH RELEVANCE: Scientific Meetings to Advance Transdisciplinary Translation for Prevention of High-Risk Behaviors Both the social and basic sciences have recently made notable advances in identifying factors that influence development of high-risk behaviors, with potentially significant implications for their prevention. Translation of this information from the basic to the prevention sciences and back again is, however, lacking. We propose to hold two round-table meetings for 60 experts to "connect the dots" across the translational spectrum by identifying pressing scientific questions in prevention research, as well as the collaborations and capabilities needed to address them with a goal to apply this knowledge toward developing more effective preventive interventions and policies, thus having extraordinary potential significance for mental and public health policy.

描述（由申请人提供）：推进跨学科翻译以预防高风险行为的科学会议 几位跨领域、具有前瞻性的研究人员，处于社会（地理空间测绘、情境行为科学、发展心理学、教育、社交媒体）和基础科学（遗传流行病学、表观遗传学、神经科学、化学）最近在识别影响高风险行为出现的因素方面取得了显着进展。鉴于病因社会和神经生物学风险因素也可能充当干预结果的调节因素和/或中介因素，该信息对预防高风险行为具有潜在的重大影响。然而，这些知识从基础科学到预防科学以及再回来的转移和应用仍然缺乏。特别需要这种转移来了解个体对干预措施的反应差异，以预防高风险行为并开发针对个人风险因素的新干预措施。我们建议利用R13机制举办两次圆桌会议，召集60名相关专家和顾问为核心，通过确定风险行为预防研究中紧迫的科学问题以及合作，在整个转化领域“连接点”以及解决这些问题所需的能力。这些会议旨在促进跨学科转化研究计划的相关性、操作可行性和实用性，以更好地理解干预反应个体差异背后的机制。会议将促进理论观点和实证方法的跨学科整合，以：a）确定预防科学中尚未解决的高度优先的科学问题，这些问题可能会受到新一代研究的启发，这些研究表明神经发生机制与环境相关并相互作用。促进或干扰响应干预措施的行为改变的条件； b) 构思新颖的社会心理和技术预防干预方法以及纳入跨学科科学研究结果的政策制定， c) 讨论早期职业研究人员进入转化预防领域的教育议程； d) 确定新合作的潜力，以促进预防研究转化网络的发展， e) 在会议前后对参与者进行调查，了解他们对团队科学、转化能力需求和市场分析的看法； f) 解决因纳入行为问题风险的遗传和神经生物学标记而产生的伦理问题， g) 出版诉讼程序的开放获取专着； h) 出版由一部分与会者撰写的两本特别期刊版本，他们将使用最先进的统计技术重新分析他们的临床试验数据集，以阐明其干预措施的机械效应，并报告在会议期间形成的新合作的进展和初步结果会议。 公共卫生相关性：推动跨学科转化预防高风险行为的科学会议最近，社会科学和基础科学在识别影响高风险行为发展的因素方面取得了显着进展，对其预防具有潜在的重大影响。然而，这些信息从基础科学到预防科学的转换还很缺乏。我们建议为 60 名专家举办两次圆桌会议，通过确定预防研究中紧迫的科学问题以及解决这些问题所需的合作和能力，以“连接各个领域的点”，从而将这些知识应用于制定更有效的预防干预措施和政策，从而对精神和公共卫生政策具有非凡的潜在意义。