Advancing Transdisciplinary Translation for Prevention of High-Risk Behaviors

推进跨学科翻译以预防高风险行为

基本信息

批准号：
8338758
负责人：
DIANA H FISHBEIN
金额：
$ 4.89万
依托单位：
RESEARCH TRIANGLE INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-26 至 2014-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8338758
关键词：
Address Aggressive behavior Applications Grants Back Basic Science Behavioral Behavioral Sciences Chemistry Child Clinical Trials Collaborations Data Set Development Drug abuse Education Engineering Environmental Exposure Epidemiology Epigenetic Process Ethical Issues Etiology Funding Gambling Generations Genetic Goals Health Policy Individual Individual Differences Intervention Intervention Studies Journals Knowledge Light Maps Marketing Mediator of activation protein Mental Health Methodology Methods Monograph Neurobiology Neurosciences Outcome Participant Perception Physics Pilot Projects Policies Policy Developments Prevention Prevention Research Preventive Intervention Problem behavior Process Progress Reports Public Health Publications Publishing Research Research Infrastructure Research Personnel Research Priority Risk Risk Behaviors Risk Factors Risk Marker Science Science of genetics Social Sciences Solutions Source Surveys Systems Biology Techniques Thinking Translational Research Translations Work career design developmental psychology follow-up forging genetic epidemiology high risk behavior high-risk behavior prevention innovation meetings neurogenetics novel prevent programs prospective psychosocial response social symposium theories

项目摘要

DESCRIPTION (provided by applicant): Scientific Meetings to Advance Transdisciplinary Translation for Prevention of High-Risk Behaviors Several cross-cutting, forward-thinking investigators on the leading edge of both the social (geospatial mapping, contextual behavioral science, developmental psychology, education, social media) and basic sciences (genetic epidemiology, epigenetics, neuroscience, chemistry) have recently made notable advances in identifying factors that influence emergence of high-risk behaviors. This information has potentially significant implications for the prevention of high-risk behaviors, given that etiological social and neurobiological risk factors may also operate as moderators and/or mediators of intervention outcomes. Transfer and application of this knowledge from the basic to the prevention sciences and back again is, however, lacking. This transfer is particularly needed to understand differences in individual response to interventions to prevent high-risk behaviors and develop new interventions tailored for an individual's risk factors. We propose to use the R13 mechanism to hold two round-table meetings that convene a core of 60 relevant experts and advisors to "connect the dots" across the translational spectrum by identifying pressing scientific questions in risk behavior prevention research, as well as the collaborations and capabilities needed to address them. These meetings are designed to facilitate the relevance, operational feasibility, and utility of a transdisciplinary translational program of research to gain a better understanding of the mechanisms underlying individual differences in intervention responsivity. Meetings will promote a cross-disciplinary integration of theoretical perspectives and empirical methods to: a) identify high priority scientific questions yet to be addressed in the prevention sciences that may be informed by a new generation of research suggesting that neurogenetic mechanisms correlate and interact with environmental conditions to promote or interfere with behavioral change in response to interventions; b) conceive of novel psychosocial and technological preventive intervention approaches and policy developments that incorporate transdisciplinary scientific findings, c) discuss an educational agenda for early career researchers to move into translational prevention; d) identify potentialities for new collaborations that will facilitate the advancement of a Translational Network for prevention research, e) conduct a survey of participants for their perceptions before and after the conferences regarding team science, needs for translational competencies, and market analysis; f) address ethical issues arising from inclusion of genetic and neurobiological markers of risk for behavioral problems, g) publish an open-access monograph of the proceedings; h) publish two special journal editions authored by a subset of attendees who will reanalyze their clinical trials datasets using state-of-the-art statistical techniques to elucidate mechanistic effects of their interventions, and report progress and preliminary findings from new collaborations forged during the meetings.

描述（由申请人提供）：促进跨学科翻译的科学会议，以预防高风险行为，以了解社会的领先地位（地理空间映射，情境行为科学，发展心理学，发展心理学，教育，教育，教育，教育，教育，教育，教育，社交媒体）和基础科学（遗传流行病学，表观遗传学，神经科学，化学）最近在识别影响高风险行为出现的因素方面取得了显着进步。鉴于病因社会和神经生物学风险因素也可能作为主持人和/或干预结果中介人，因此这些信息对预防高风险行为具有潜在的重要意义。但是，缺乏这些知识从基础转移到预防科学并再次返回的知识。特别需要这种转移才能了解个人对干预措施的反应差异，以防止高风险行为并制定针对个人风险因素量身定制的新干预措施。我们建议使用R13机制举办两次圆桌会议，召集60位相关专家和顾问的核心，以通过确定预防风险行为研究中的迫切科学问题以及协作，以在整个翻译范围内“连接点”。以及解决方案所需的功能。这些会议旨在促进跨学科翻译计划的相关性，运营可行性和实用性，以更好地了解干预反应性中个体差异的机制。会议将促进理论观点和经验方法的跨学科整合：a）确定在预防科学中尚待解决的高优先级科学问题，这些问题可能会通过新一代研究来告知，这表明神经遗传机制与环境相关并与环境相互作用促进或干扰干预措施的行为变化的条件； b）构思新颖的社会心理和技术预防性干预方法和政策发展，结合了跨学科的科学发现，c）讨论早期职业研究人员进入转化预防的教育议程； d）确定新合作的潜力，这将有助于预防研究转化网络的发展，e）对参与者的调查，以了解他们在有关团队科学，转化能力需求和市场分析的会议之前和之后的看法； f）解决由行为问题风险的遗传和神经生物学标志所引起的道德问题，g）发表会议记录的开放式专着； h）出版了由与会者子集撰写的两个特殊期刊版本，他们将使用最先进的统计技术重新分析其临床试验数据集，以阐明其干预措施的机械效果，并报告进度和初步的发现，从新的合作结果中进行了新的合作结果。会议。