Neuroendocrine Control of Paternal Care in the Common Marmoset

普通狨猴父亲照顾的神经内分泌控制

基本信息

批准号：
7754881
负责人：
Toni Elaine ZIEGLER
金额：
$ 14.51万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-01-05 至 2010-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7754881
关键词：
Adult Anterior Anterior Pituitary Gland Behavior Behavioral Birth Brain Callithrix Callithrix jacchus jacchus Caring Child Development Communication Cues Development Disease Dopamine Dose Estradiol Event Exhibits Fathers Female Foundations Health Hormonal Hormonal Change Human Hypothalamic structure In Vitro Infant Infant Care Mammals Maternal Behavior Monitor Neurosecretory Systems Outcome Oxytocin Parenting behavior Partner in relationship Paternal Behavior Pathway interactions Peptides Peripheral Pituitary Gland Pituitary Hormones Posterior Pituitary Gland Pregnancy Primates Production Prolactin Rodent Role Sampling Sheep Steroids Stimulus Study models Testing Testosterone Ursidae Family Vasopressins abuse neglect experience family structure in vitro testing in vivo male method development novel offspring psychosocial public health relevance relating to nervous system reproductive research study response social organization steroid hormone therapy development

项目摘要

DESCRIPTION (provided by applicant): The use of the exploratory/development mechanism was chosen to allow for the development of methods to examine the hormonal pathway for priming paternal care behaviors in biparental males. The common marmoset, Callithrix jacchus, is the ideal model for studying hormonal activation of male parental care due to their active participation in infant care from the first day of birth. Fathers are highly responsive to infant cues, but show between male variability as do human fathers. Parentally naive males are much less responsive to infant cues than experienced males, suggesting there is an experience and hormonal influence on paternal behavior. Specific Aim 1 will test paternally experienced adult male marmosets for their infant responsiveness to an infant or control stimulus by steroid treatment with either estradiol or testosterone or vehicle. We will examine changes in prolactin, oxytocin, vasopressin and dopamine with steroid stimulation in both central and peripheral samples. Specific Aim 2 will examine the communication between the anterior and posterior pituitary through culturing both intact and separated pituitaries before and after steroid challenges. Changes in levels of pituitary hormones will be compared to in vivo changes found in Specific Aim 1. Specific Aim 3 will test paternally naive males for their infant responsiveness by steroid treatment, as in Specific Aim 1 and for their pituitary responses as in Specific Aim 2. Inexperienced male's behavioral and hormonal responses will be compared to experienced males and pituitary responses to steroid treatment will be compared with the experienced males. Marmosets are one of the few mammalian species whose social organization/family structure bears resemblance to that of humans. Poor parenting results in a number of pyschosocial disorders, such as neglect and abuse, which confound human health. Understanding the mechanisms of paternal care in a bi-parental species will lay the foundation for development of treatments to create positive parenting. PUBLIC HEALTH RELEVANCE: This project seeks to understand the factors underlying quality paternal care in males. With poor parenting or parental absence, there are a number of psychosocial disorders that confound human health. Fathers can contribute significantly to the positive outcome of infant and child development.

描述（由申请人提供）：选择使用探索/开发机制是为了开发检查荷尔蒙途径的方法，以启动双亲男性的父亲照顾行为。普通狨猴（Callithrix jacchus）是研究雄性父母照顾荷尔蒙激活的理想模型，因为它们从婴儿出生的第一天起就积极参与婴儿照顾。父亲对婴儿的暗示高度敏感，但与人类父亲一样，男性之间也存在差异。与有经验的男性相比，幼稚的男性对婴儿暗示的反应要少得多，这表明经验和荷尔蒙对父亲的行为有影响。具体目标 1 将测试有父爱经验的成年雄性狨猴对婴儿的婴儿反应，或通过雌二醇或睾酮或媒介物进行类固醇治疗来控制刺激。我们将检查中枢和外周样本中催乳素、催产素、加压素和多巴胺在类固醇刺激下的变化。具体目标 2 将通过在类固醇挑战之前和之后培养完整和分离的垂体来检查垂体前叶和后叶之间的通讯。垂体激素水平的变化将与特定目标 1 中发现的体内变化进行比较。特定目标 3 将测试未受父亲影响的男性对类固醇治疗的婴儿反应（如特定目标 1 中所示）和垂体反应（如特定目标 2 中所示）缺乏经验的男性的行为和激素反应将与有经验的男性进行比较，垂体对类固醇治疗的反应将与有经验的男性进行比较。狨猴是少数几种社会组织/家庭结构与人类相似的哺乳动物之一。不良的养育方式会导致许多心理社会障碍，例如忽视和虐待，从而影响人类健康。了解双亲物种的父亲照顾机制将为开发治疗方法奠定基础，以创造积极的养育方式。公共健康相关性：该项目旨在了解男性优质父亲护理的潜在因素。由于养育不当或父母缺席，会出现许多影响人类健康的社会心理疾病。父亲可以为婴儿和儿童发展的积极成果做出重大贡献。