NEUROENDOCRINE CONTROL OF PATERNAL CARE IN THE COMMON MARMOSET

狨猴父亲照顾的神经内分泌控制

• 批准号: 8173136
• 负责人: Toni Elaine ZIEGLER
• 金额: $ 3.1万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173136
• 关键词: Animals; Anterior; Behavior; Biological Assay; Callithrix; Callithrix jacchus jacchus; Caring; Cells; Computer Retrieval of Information on Scientific Projects Database; Disease; Distress; Dopamine; Estradiol; Fathers; Funding; Grant; Health; Hormonal; Human; Infant; Institution; Measures; Neurosecretory Systems; Oxytocin; Parenting behavior; Pathway interactions; Pituitary Gland; Posterior Pituitary Gland; Prolactin; Research; Research Design; Research Personnel; Research Project Grants; Resources; Services; Signal Transduction; Source; Stimulus; United States National Institutes of Health; Ursidae Family; Vasopressins; experience; family structure; male; psychosocial; response; social organization

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To determine the factors underlying quality paternal care in male marmosets. With poor parenting or parental absence, there are a number of psychosocial disorders that confound human health. Marmosets are one of the few mammalian species whose social organization/family structure bears resemblance to that of humans. These studies are designed to determine the hormonal pathway for priming paternal care behaviors in biparental males who show extensive parental care. With the first year of the grant ending, we have all specific aims ongoing. In specific aim 1 we have found that increased estradiol significantly stimulates males to be more attentive to infant distress signals in na¿ve males. Males who have not been fathers before show little responsiveness to infant stimuli while experienced fathers show significant response to infant stimuli. In specific aim 2&3 we are measuring dopamine, oxytocin, vasopressin and prolactin in pituitary cells of intact anterior and posterior pituitaries as well as each pituitary cultured separately for experienced and na¿ve males. Initial results are revealing significant differences between experienced fathers and na¿ve males in their levels of prolactin and oxytocin but not vasopressin. Experienced fathers have significantly higher prolactin and oxytocin than na¿ve fathers. This research project, now in its second year, relies on WNPRC Assay Services and Animal Services.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以出现在其他 CRISP 条目中 列出的机构是。 对于中心来说，它不一定是研究者的机构。 目的：确定雄性狨猴优质父亲护理的影响因素。 由于养育不当或父母缺席，狨猴是少数社会组织/家庭结构与人类相似的哺乳动物物种之一，这些研究旨在确定荷尔蒙途径。在资助结束的第一年，我们发现雌二醇的增加显着刺激了男性的生育能力。留意婴儿的求救信号以前没有当过父亲的男性对婴儿刺激几乎没有反应，而有经验的父亲对婴儿刺激表现出显着的反应，在具体目标 2 和 3 中，我们测量了完整垂体前叶和后叶垂体细胞中的多巴胺、催产素、加压素和催乳素。以及每个垂体分别培养的经验丰富的和na¿初步结果揭示了经验丰富的父亲和新手父亲之间的显着差异。五名男性的催乳素和催产素水平显着高于正常父亲，但有经验的父亲的催乳素和催产素水平却没有。我们的父亲们。 该研究项目现已进入第二年，依赖于 WNPRC 检测服务和动物服务。