NEUROENDOCRINE CONTROL OF PATERNAL CARE IN THE COMMON MARMOSET

狨猴父亲照顾的神经内分泌控制

• 批准号: 8173136
• 负责人: Toni Elaine ZIEGLER
• 金额: $ 3.1万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173136
• 关键词: Animals; Anterior; Behavior; Biological Assay; Callithrix; Callithrix jacchus jacchus; Caring; Cells; Computer Retrieval of Information on Scientific Projects Database; Disease; Distress; Dopamine; Estradiol; Fathers; Funding; Grant; Health; Hormonal; Human; Infant; Institution; Measures; Neurosecretory Systems; Oxytocin; Parenting behavior; Pathway interactions; Pituitary Gland; Posterior Pituitary Gland; Prolactin; Research; Research Design; Research Personnel; Research Project Grants; Resources; Services; Signal Transduction; Source; Stimulus; United States National Institutes of Health; Ursidae Family; Vasopressins; experience; family structure; male; psychosocial; response; social organization

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To determine the factors underlying quality paternal care in male marmosets. With poor parenting or parental absence, there are a number of psychosocial disorders that confound human health. Marmosets are one of the few mammalian species whose social organization/family structure bears resemblance to that of humans. These studies are designed to determine the hormonal pathway for priming paternal care behaviors in biparental males who show extensive parental care. With the first year of the grant ending, we have all specific aims ongoing. In specific aim 1 we have found that increased estradiol significantly stimulates males to be more attentive to infant distress signals in na¿ve males. Males who have not been fathers before show little responsiveness to infant stimuli while experienced fathers show significant response to infant stimuli. In specific aim 2&3 we are measuring dopamine, oxytocin, vasopressin and prolactin in pituitary cells of intact anterior and posterior pituitaries as well as each pituitary cultured separately for experienced and na¿ve males. Initial results are revealing significant differences between experienced fathers and na¿ve males in their levels of prolactin and oxytocin but not vasopressin. Experienced fathers have significantly higher prolactin and oxytocin than na¿ve fathers. This research project, now in its second year, relies on WNPRC Assay Services and Animal Services.

该副本是使用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这是调查员的机构。 目的：确定雄性果酱中质量父亲护理的基本因素。 由于育儿或父母的缺席，有许多使人健康混淆的社会心理障碍。摩尔果是其社会组织/家庭结构与人类相似的少数哺乳动物物种之一。这些研究旨在确定表现出广泛父母护理的二聚体男性启动模式护理行为的马途径。随着赠款结束的第一年，我们都在进行所有特定的目标。具体目的1我们发现，雌二醇增加会显着刺激雄性对NATHE雄性的婴儿遇险信号更加专注。在经验丰富的父亲表现出对婴儿刺激的重大反应时，对婴儿刺激的反应很小，但对婴儿刺激的反应很少。在特定的目标2和3中，我们正在测量完整前和垂体后垂体的垂体细胞中的多巴胺，氧气，加压素和催乳素，以及为经验丰富的雄性分别培养的每个垂体。最初的结果表明，经验丰富的父亲和纳雷斯之间的催乳素和氧气水平上没有差异，但没有加压素。经验丰富的父亲的催乳素和氧气明显高于Na¿ 该研究项目现在已经第二年了，依赖于WNPRC测定服务和动物服务。