Corticothalamic circuits mediating behavioral adaptations to unexpected reward omission

皮质丘脑回路介导对意外奖励遗漏的行为适应

基本信息

批准号：
10734683
负责人：
Michael Beierlein
金额：
$ 60.11万
依托单位：
UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-07-13 至 2028-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10734683
关键词：
Amygdaloid structure Animal Behavior Animals Anterior Anxiety Disorders Area Attenuated Behavior Behavioral Behavioral Paradigm Brain Cell Nucleus Conditioned Stimulus Conflict (Psychology)Cues Desire for food Detection Dopamine Electrophysiology (science)Exposure to Extinction Food Frequencies Frustration Glutamates Human In Vitro Laboratory Rat Lead Maintenance Mediating Mental Depression Modification Motivation Movement Neurons Nucleus Accumbens Organism Outcome Partner in relationship Pathway interactions Pattern Phase Population Predictive Value Prefrontal Cortex Property Rattus Rewards Role Sensory Shelter facility Signal Transduction Slice Social Interaction Structure Structure of paraventricular nucleus of thalamus Sucrose Synapses Synaptic plasticity Testing Thalamic structure Training Update Ventral Tegmental Area Water attenuation behavioral response dopaminergic neuron emotion regulation emotional distress experimental study gain of function genetic manipulation in vivo insight loss of function negative affect neural neural circuit neuronal circuitry optogenetics photoactivation pressure response

Amygdaloid structure Animal Behavior Animals Anterior Anxiety Disorders Area Attenuated Behavior Behavioral Behavioral Paradigm Brain Cell Nucleus Conditioned Stimulus Conflict (Psychology)Cues Desire for food Detection Dopamine Electrophysiology (science)Exposure to Extinction Food Frequencies Frustration Glutamates Human In Vitro Laboratory Rat Lead Maintenance Mediating Mental Depression Modification Motivation Movement Neurons Nucleus Accumbens Organism Outcome Partner in relationship Pathway interactions Pattern Phase Population Predictive Value Prefrontal Cortex Property Rattus Rewards Role Sensory Shelter facility Signal Transduction Slice Social Interaction Structure Structure of paraventricular nucleus of thalamus Sucrose Synapses Synaptic plasticity Testing Thalamic structure Training Update Ventral Tegmental Area Water attenuation behavioral response dopaminergic neuron emotion regulation emotional distress experimental study gain of function genetic manipulation in vivo insight loss of function negative affect neural neural circuit neuronal circuitry optogenetics photoactivation pressure response

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项目摘要

PROJECT SUMMARY/ABSTRACT Environmental cues that are associated with food develop attractive and motivational properties that elicit reward-seeking behaviors in animals. However, when food-associated cues no longer lead to rewards, animals quickly adjust their behaviors by showing a transient increase of reward-seeking responses (invigoration) and a set of behavioral responses that resemble frustrative behaviors in humans. Repeated exposure to reward omission leads to behavioral attenuation that serves to suppress unproductive appetitive responses. Although significant progress has been made in elucidating the brain structures that regulate the acquisition and the extinction of reward-seeking responses, the neural circuits and brain mechanisms that control changes in behavioral responses during the initial phase of reward omission remain elusive. Emerging evidence suggests that neurons in the anterior portion of the paraventricular nucleus of the thalamus (aPVT) are activated by reward- associated cues and contribute to the regulation of emotional responses during unexpected omission of reward. Whereas activity in the aPVT to nucleus accumbens pathway decreases reward seeking, activity in the aPVT to central amygdala pathway increases it, suggesting that the aPVT is a potential candidate to regulate behavioral invigoration during reward omission. Here we propose to study how cortical and subcortical inputs to the aPVT regulate the dynamic activity of projection-defined aPVT neurons during reward omission. Using in vitro electrophysiology, we will study the intrinsic properties and synaptic dynamics of distinct aPVT neurons and their afferents. Using a food-seeking task in which rats are exposed to reward omission, we will investigate the neuronal activity patterns of aPVT neurons in vivo, and correlate their activity with the animal's behavior during the test. Subsequent gain-of-function and loss-of-function experiments will test the sufficiency and necessity of distinct aPVT afferents. These experiments will provide insights into the neural circuits that detect changes in reward availability and rapidly adjust animals' behavior during the initial phase of reward omission.

项目摘要/摘要与粮食相关的环境线索发展有吸引力的动机性能动物的奖励行为。但是，当食物相关的提示不再带来奖励时，动物通过显示寻求奖励反应的短暂增加（振兴）和a，快速调整其行为在人类中类似于挫败行为的行为反应集。反复接触奖励遗漏会导致行为衰减，可抑制非生产性的食欲反应。虽然在阐明调节采集和的大脑结构方面取得了重大进展控制奖励反应的灭绝，控制变化的神经回路和大脑机制在奖励遗漏的初始阶段的行为反应仍然难以捉摸。新兴证据表明丘脑（APVT）的室室核的前部神经元被奖励激活在意外省略奖励期间，相关线索并有助于调节情绪反应。而APVT对伏隔核的活性会降低寻求奖励，而APVT的活性为中央杏仁核途径增加了它，表明APVT是调节行为的潜在候选者奖励遗漏期间的振兴。在这里，我们建议研究对APVT的皮质和皮质下输入在奖励遗漏期间，调节投影定义的APVT神经元的动态活性。在体外使用电生理学，我们将研究不同APVT神经元及其的内在特性和突触动力学传入。使用寻求食物的任务，使大鼠暴露于奖励遗漏，我们将调查 APVT神经元在体内的神经元活动模式，并将其活性与动物的行为相关联测试。随后的功能获得和功能丧失实验将测试足够和必要性独特的APVT传入。这些实验将为检测变化的神经回路提供见解奖励可用性并在奖励遗漏的初始阶段迅速调整动物的行为。