NEUROENDOCRINE RESPONSE TO FEMALE OVULATORY ODORS IN COOPERATIVE BREEDERS

合作饲养者对女性排卵气味的神经内分泌反应

• 批准号: 7958758
• 负责人: Toni Elaine ZIEGLER
• 金额: $ 4.68万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7958758
• 关键词: Affect; Birth; Breeding; Callithrix; Callithrix jacchus jacchus; Caring; Chemicals; Communication; Computer Retrieval of Information on Scientific Projects Database; Cues; Data; Family member; Fathers; Female; Funding; Gonadal structure; Grant; Human; Hypothalamic structure; Infant; Infant Care; Institution; Life; Modeling; Neuroendocrinology; Neurosecretory Systems; Odors; Parenting behavior; Partner in relationship; Paternal Behavior; Personal Satisfaction; Pituitary Gland; Play; Primates; Publications; Reporting; Research; Research Personnel; Resources; Role; Sensory; Serum; Smell Perception; Social Change; Societies; Source; System; Testosterone; United States National Institutes of Health; Wisconsin; experience; fatherhood; fitness; male; novel; offspring; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To determine how chemical communication activates the neuroendocrinology of cooperative breeding primates. Fathers of cooperatively breeding species of primates play a critical role in the successful rearing of offspring. While all family members of primate cooperative breeders carry infants, only the father provides the full range of infant care, such as assisting during the critical first days of life. Human fathers are extremely important to the well-being and increased fitness of their offspring and several studies have found that human fathers show lower levels of testosterone associated with paternal care in several different societies. The cooperative breeding male common marmoset (Callithrix jacchus) is especially responsive to social changes altering testosterone. Males show increased levels of serum testosterone in response to smelling isolated ovulatory scents of novel females and father marmosets show decreased testosterone after the birth of infants to their mate (Prudom et al., 2007). Marmosets show the same lowered testosterone response to fatherhood as human fathers, making them a unique model to study neurosensory systems and paternal behavior. Neurosensory mechanisms influence male testosterone in cooperative or monogamous primates. Recent studies in our lab have found a neurosensory mechanism occurring in father marmosets via infant olfactory cues. We have found significant differences between testosterone levels in father marmosets when smelling their own infant's scent versus smelling a vehicle control. Fathers that are experienced at rearing their own infants have significantly lower testosterone 30 minutes following smelling an isolated scent of their own three-week-old infant whereas inexperienced males, or males who have never produced and raised their own offspring show no differences between vehicle and unfamiliar three-week-old infant scent. These data suggest that a father's own infant odor (without other sensory cues) stimulates the olfactory system and ultimately stimulates the hypothalamus and pituitary to affect the release of testosterone from the gonads. The consistently lowered testosterone following birth in marmoset fathers may be due to the olfactory interactions of the male with his infants resulting in positive parenting behavior. Funding ended before this reporting period; one publication resulted.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 目的：确定化学通讯如何激活合作繁殖灵长类动物的神经内分泌。 合作繁殖灵长类动物的父亲在成功培育后代方面发挥着至关重要的作用。 虽然灵长类动物合作饲养者的所有家庭成员都携带婴儿，但只有父亲提供全方位的婴儿护理，例如在生命的关键第一天提供帮助。 人类父亲对于后代的福祉和增强体质极其重要，多项研究发现，在几个不同的社会中，人类父亲的睾酮水平较低，与父亲的照顾有关。 合作繁殖的雄性普通狨猴（Callithrix jacchus）对改变睾酮水平的社会变化特别敏感。 雄性狨猴在闻到新雌性狨猴的排卵气味后，其血清睾酮水平会升高，而父亲狨猴在其配偶生下婴儿后，其睾酮水平会下降（Prudom 等，2007）。 狨猴对父亲的睾酮反应与人类父亲一样降低，这使它们成为研究神经感觉系统和父亲行为的独特模型。 神经感觉机制影响合作或一夫一妻制灵长类动物的雄性睾酮。我们实验室最近的研究发现，狨猴父亲通过婴儿嗅觉线索发生了一种神经感觉机制。 我们发现，狨猴父亲在闻自己婴儿的气味时与闻媒介物对照时的睾酮水平存在显着差异。有抚养自己婴儿经验的父亲在闻到自己三周大婴儿的气味后 30 分钟后，其睾酮水平显着降低，而缺乏经验的男性或从未生育和抚养自己后代的男性在车辆和车辆之间没有差异。三周大的婴儿不熟悉的气味。这些数据表明，父亲自己的婴儿气味（没有其他感官线索）会刺激嗅觉系统，并最终刺激下丘脑和垂体，从而影响性腺释放睾酮。 狨猴父亲出生后睾丸激素持续降低，可能是由于雄性与其婴儿的嗅觉相互作用导致了积极的养育行为。 资助在本报告期之前结束；结果发表了一份出版物。