IMPORTANCE OF PATERNAL CARE

父亲照顾的重要性

• 批准号: 8173072
• 负责人: Toni Elaine ZIEGLER
• 金额: $ 3.1万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173072
• 关键词: American; Behavior; Biological Assay; Birds; Birth; Body Weight decreased; Breeding; Callithrix; Callithrix jacchus jacchus; Caring; Computer Retrieval of Information on Scientific Projects Database; Estradiol; Etiology; Family; Fathers; Fishes; Funding; Grant; Hormonal; Hormones; Human Biology; Infant; Infant Care; Institution; Journals; Methods; Monkeys; Neurosecretory Systems; Parenting behavior; Parents; Partner in relationship; Postpartum Period; Pregnancy; Primates; Prolactin; Publications; Reporting; Research; Research Personnel; Resources; Role; Sampling; Serum; Services; Source; Stimulus; Testing; Testosterone; United States National Institutes of Health; Variant; Weight; Weight Gain; design; experience; male; reproductive hormone; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To determine the facilitators of good parenting in primates. Prolactin has been implicated in promoting paternal care behaviors but little evidence of causality has been found to date except for birds and fish. This study was designed to examine the possible causal relationships between prolactin and male parenting behaviors, reproductive hormones, and physical changes in cooperatively breeding common marmosets, Callithrix jacchus. Fifteen parentally experienced fathers were studied over three consecutive infant care periods during two weeks prior and three weeks following their mates' parturition under three-treatment conditions: normal control pregnancy, decreased prolactin and elevated prolactin. The treatments significantly altered the serum prolactin levels in the fathers. Using three methods of determining a father's level of parental care: infant carrying, family effort and responsiveness to infant stimulus tests, we found that only the male's response to infant stimuli was altered by the hormone treatments. Lowering prolactin significantly reduced male responsiveness to infant stimuli but elevating prolactin showed the same effect. Hormonal sampling indicated that testosterone levels showed an inverse relationship to prolactin levels during a normal peripartum period and prolactin treatment reduced this relationship. Prepartum estradiol levels were significantly elevated during the lowered prolactin treatment and estradiol was significantly lowered postpartum with the elevated prolactin treatment. Father's weight decreased significantly by the third week of infant care during the normal treatment. Males in the elevated prolactin treatment lost little or no weight from prepartum while in the lowered prolactin treatment showed the most weight loss. The present findings did not distinguish a direct causal relationship of prolactin on behavior in experienced fathers but did find an interaction with other hormones and weight gain. This research used WNPRC Assay Services and the marmoset colony. Funding ended before this reporting period; publications have resulted. PUBLICATIONS: Ziegler TE, Prudom SL, Zahed SR, Parlow AF, Wegner F (2009). Prolactin's mediative role in male parenting in parentally experienced marmosets (Callithrix jacchus). HORMONES AND BEHAVIOR 56:436-443. PMCID: PMC2761515 Ziegler, TE, Prudom, SL, Zahed, SR. (2009). Variation in male parenting in the common marmoset monkey and its neuroendocrine control. AMERICAN JOURNAL OF HUMAN BIOLOGY, 21: 739-744. PMID: 19367571

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 目的：确定灵长类动物良好养育的促进因素。 催乳素与促进父亲照顾行为有关，但迄今为止，除了鸟类和鱼类之外，几乎没有发现因果关系的证据。本研究旨在探讨催乳素与雄性养育行为、生殖激素以及合作繁殖普通狨猴 Callithrix jacchus 的身体变化之间可能存在的因果关系。研究人员对 15 位有育儿经验的父亲在其配偶分娩前两周和分娩后三周的三个连续婴儿护理期进行了研究，研究对象采用三种治疗条件：正常对照妊娠、催乳素下降和催乳素升高。这些治疗显着改变了父亲的血清催乳素水平。使用三种确定父亲养育水平的方法：婴儿携带、家庭努力和对婴儿刺激测试的反应，我们发现只有男性对婴儿刺激的反应会因激素治疗而改变。降低催乳素可显着降低男性对婴儿刺激的反应，但提高催乳素则显示出相同的效果。激素取样表明，在正常围产期，睾酮水平与催乳素水平呈负相关，而催乳素治疗降低了这种关系。在降低催乳素治疗期间，产前雌二醇水平显着升高，而在升高催乳素治疗期间，雌二醇水平显着降低。在正常治疗期间，到婴儿护理第三周时，父亲的体重明显下降。接受升高催乳素治疗的男性产前体重几乎没有减轻或没有减轻，而接受降低催乳素治疗的男性则体重减轻最多。目前的研究结果并未区分催乳素与经验丰富的父亲的行为之间的直接因果关系，但确实发现了与其他激素和体重增加的相互作用。 这项研究使用了 WNPRC 检测服务和狨猴群体。 资助在本报告期之前结束；出版物已产生。 出版物： 齐格勒 TE、普鲁多姆 SL、扎赫德 SR、帕洛 AF、韦格纳 F (2009)。催乳素在有育儿经验的狨猴（Callithrix jacchus）的雄性育儿中的中介作用。激素与行为 56：436-443。 PMCID：PMC2761515 TE 齐格勒、SL 普鲁多姆、SR 扎赫德。 （2009）。普通狨猴雄性养育方式的变异及其神经内分泌控制。美国人类生物学杂志，21：739-744。 PMID：19367571