Project: Survivorship Care Physical Activity Initiative to Improve Disparities in HRQoL for Prostate Cancer Survivors (RELate Study)

项目：旨在改善前列腺癌幸存者 HRQoL 差异的生存护理体力活动计划（RELate 研究）

• 批准号: 10911646
• 负责人: David Paul Turner
• 金额: $ 0.75万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10911646
• 关键词: Address; Adherence; Advanced Glycosylation End Products; Affect; African ancestry; American; Behavior; Biological; Black Populations; Blood; Blood specimen; Cancer Cell Growth; Cancer Center; Cancer Patient; Cancer Prognosis; Cancer Survivor; Cancer Survivorship; Cardiopulmonary rehabilitation; Cardiovascular system; Caring; Cell Differentiation process; Cells; Chronic; Circulation; Clinical; Collaborations; Detection; Diagnosis; Diet; Dietary Intervention; Disease; Disparity; Enzyme-Linked Immunosorbent Assay; European; Exercise; Feasibility Studies; Helper-Inducer T-Lymphocyte; Human; Immune; Immune response; Inflammatory; Interferon Type II; Intervention; Invaded; Knock-out; Late Effects; Life Style; Malignant neoplasm of prostate; Mass Spectrum Analysis; Mediating; Medical; Medical center; Membrane; Mental Depression; Metabolism; Mus; NF-kappa B; Nonmetastatic; Obesity; Outcome; Oxidative Stress; Participant; Pathogenicity; Pathway interactions; Patients; Peripheral Blood Mononuclear Cell; Phase; Phenotype; Physical activity; Prognosis; Prostate Cancer therapy; Psychosocial Influences; Randomized; Regulation; Research; Research Personnel; Research Project Grants; Risk Factors; Role; Running; Serum; Sexual Dysfunction; Signal Transduction; South Carolina; TNF gene; Treatment outcome; Tumor Promotion; Unhealthy Diet; Universities; absorption; arm; biobehavior; biological adaptation to stress; cancer health disparity; cytokine; design; dietary; disparity reduction; exercise intervention; health disparity; health related quality of life; human model; immune activation; improved; in vivo; innovation; insight; lifestyle factors; lifestyle intervention; macromolecule; men; migration; modifiable risk; mouse model; novel; oxidation; pharmacologic; post intervention; prostate cancer cell; prostate cancer survivors; protective factors; randomized trial; receptor for advanced glycation endproducts; sedentary lifestyle; survivorship; treatment as usual; treatment effect; tumor; tumor growth; tumor progression; urinary

Full Research Project 1: Survivorship Care Physical Activity Initiative to Reduce Disparities in HRQOL for Prostate Cancer Survivors (RELate Study) SUMMARY The late effects of prostate cancer (PCa) treatment can lead to unique physical and psychosocial issues that impact their long-term health-related quality of life (HRQOL). Increased physical activity (PA) is a modifiable risk factor which may be targeted to address PCa survivorship-related treatment outcomes and lifestyle behaviors. Increased PA may have greatest impact on outcomes for African-ancestry (AA) PCa survivors, who tend to have lower HRQOL and overall survival, and in whom factors such as a lack of exercise, poor diet, and rates of obesity are most prevalent. While it is well-known that exercise can improve prognosis among cancer survivors, little is known about the bio-behavioral mechanisms and pathways through which PA may improve HRQOL and increase overall survival. Advanced glycation endproducts (AGEs) are reactive metabolites produced during normal metabolism as well as the oxidation of biological macromolecules. Lifestyle factors such as a sedentary lifestyle, poor diet, and obesity increase AGE levels in the body. The investigators hypothesize that in a randomized trial of a human PA/dietary intervention with PCa survivors previously diagnosed with Stage I-III PCa (n=120), lower AGE levels will correlate with improved HRQOL, and will lead to differential changes in immune response between AA and European American (EA) trial participants. The investigators further hypothesize that in a mouse model intervention, the mechanistic implications of lifestyle- associated AGEs to tumor-associated immune response and tumor growth and/or progression will mimic those found in human models. Aim 1 is to complete a 1-year, 2-arm (intervention vs usual care) randomized PA/dietary intervention in men diagnosed with stage I-III PCa (co-led by Dr. M. Ahmed, SCSU and Dr. D. Turner, MUSC-HCC). Aim 2 is to evaluate the effect of lifestyle intervention on PA and diet, and define their relationship with AGEs, AGEs pre-cursors, and HRQOL in men diagnosed with stage I-III PCa (led by Dr. Ahmed, SCSU). Aim 3 is to use a spontaneous PCa lifestyle mouse model to define the role of AGE-RAGE signaling to immune-cell phenotypes and tumor progression (led by Dr. Turner, MUSC-HCC). The results could lead to innovative insights for pharmacologic and lifestyle adjustment, and could identify protective factors that may underlie observed differences in PCa treatment outcomes between AA and EA men. This project is synergistically related to the other research projects included in this application

完整的研究项目1：生存护理体育锻炼计划，以减少HRQOL的差异 前列腺癌幸存者（相关研究） 概括 前列腺癌（PCA）治疗的后期作用可能导致独特的身体和社会心理问题 影响其长期与健康相关的生活质量（HRQOL）。增加体育锻炼（PA）是可修改的 可能针对PCA生存有关的治疗结果和生活方式的危险因素 行为。 PA的增加可能会对非洲委托人（AA）PCA幸存者的成果产生最大的影响，他 往往具有较低的HRQOL和整体生存，其中缺乏运动，饮食不良和等因素 肥胖率最普遍。虽然众所周知，运动可以改善癌症的预后 幸存者，关于PA可以改善的生物行为机制和途径知之甚少 HRQOL并增加总体生存率。晚期糖基化最终产物（年龄）是反应性代谢物 在正常代谢以及生物大分子的氧化过程中产生。生活方式因素 例如久坐的生活方式，饮食不佳和肥胖可以提高体内的年龄水平。调查人员 假设在人类PA/饮食干预与PCA幸存者的随机试验中 诊断为I-III期PCA（n = 120），较低的年龄水平将与改善的HRQOL相关，并将导致 AA和欧美（EA）试验参与者之间免疫反应的差异变化。这 研究人员进一步假设，在小鼠模型干预中，生活方式的机械含义 - 与肿瘤相关的免疫反应和肿瘤生长和/或进展的相关年龄将模仿这些年龄 在人类模型中发现。 AIM 1是完成1年，2臂（干预与通常的护理）随机分组 PA/饮食干预被诊断为I-III期PCA的男性（由M. Ahmed博士，SCSU和D. 特纳，MUSC-HCC）。目标2是评估生活方式干预对PA和饮食的影响，并定义其 与诊断为I-III期PCA的男性，与年龄，年龄的前卫和HRQOL的关系（由博士领导 艾哈迈德，SCSU）。 AIM 3是使用自发的PCA生活方式鼠标模型来定义年龄段的作用 对免疫细胞表型和肿瘤进展的信号传导（由MUSC-HCC的Turner博士领导）。结果 可能导致对药理和生活方式调整的创新见解，并可以识别保护性 可能观察到AA和EA男性之间PCA治疗结果差异的因素。这 项目与本应用程序中包含的其他研究项目协同关联