2021 Neural Crest and Cranial Placodes GRC/GRS

2021 神经嵴和颅板 GRC/GRS

基本信息

批准号：
10765885
负责人：
Paul Trainor
金额：
$ 0.3万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-04-01 至 2023-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10765885
关键词：
Acceleration Achievement Address Adrenal Glands Adult Anterior Pituitary Gland Biological Models Biology Biomedical Research Cancer Biology Cardiac Cardiac Myocytes Cartilage Cells Cephalic Childhood Solid Neoplasm Chromaffin Cells Ciliary Muscle Clinical Collaborations Communities Congenital Abnormality Congenital Disorders Connective Tissue Corneal Endothelium Craniofacial Abnormalities Data Dedications Defect Development Disease Ectoderm Education Educational workshop Embryonic Development Endocrine Enteral Epithelium Equilibrium Evolution Eye Face Feedback Fertility Fostering Gender Genomics Goals Head Heart Heart Septum Homeostasis Hour Individual International Labyrinth Malignant Neoplasms Mentors Mentorship Mesenchymal Modeling Morphogenesis Morphology Neoplasm Metastasis Neural Crest Neural Crest Cell Neuroglia Neurons Nose Odontoblasts Oral Organ Participant Pathogenesis Pattern Peripheral Physiological Pigments Population Postdoctoral Fellow Proteomics Regenerative Medicine Research Research Personnel Science Scientist Sense Organs Sensory Sensory Ganglia Sensory Receptors Skin Supporting Cell System Systems Biology Taste Buds Technology Time Tissue Engineering Tissues Tooth structure Trigeminal System Underrepresented Minority Visceral Woman Work bone career career networking cell type disability experience gastrointestinal graduate student human stem cells innovation insight lateral line lens meetings migration neoplastic cell nerve supply neural plate neurodevelopment neurotransmission novel novel strategies peer peer networks posters regenerative biology somatosensory stem cell biology stem cells supportive environment symposium technological innovation transcriptomics

项目摘要

PROJECT SUMMARY Neural crest cells and cranial placodes share evolutionary and embryological origins and are of fundamental importance to vertebrate development, evolution and disease. Together, they form the cranial sensory ganglia, but individually they each give rise to an incredibly diverse array of cell types and tissues. Neural crest cells form most of the bone, cartilage and connective tissue of the head and face, the dentine-producing odontoblasts of teeth, the ciliary muscles and corneal endothelium of the eye, cardiomyocytes and aorticopulmonary septum of the heart, chromaffin cells in the adrenal gland, pigment cells in the skin, all peripheral glia, peripheral autonomic and enteric neurons, and most peripheral somatosensory neurons. Placodes form the sensory receptors, afferent innervation and support cells of the paired peripheral sense organs (nose, inner ear, lateral line system), the lenses of the paired eyes, cranial somatosensory (trigeminal) neurons and visceral sensory (epibranchial) neurons that transmit a wide variety of information from the heart, gut and other visceral organs, as well as taste buds, and the endocrine adenohypophysis which is important for fertility and homeostasis. Neural crest cells and cranial placodes provide experimental paradigms for studying cell and tissue induction, stem cell multipotency, patterning, morphogenesis, invagination, epithelial-mesenchymal transition, migration and differentiation. Neural crest cells and placodes are synonymous with vertebrate evolution, and defects in their development underlie a broad range of birth defects and diseases including craniofacial malformations, cardiac and gastrointestinal anomalies, sensory deficits, abnormal physiological function and cancer. This GRC and GRS on Neural Crest Cells and Cranial Placodes brings together a diverse group of leading scientists working on all aspects of neural crest cell and placode biology. The conference offers the chance to present unpublished data and novel approaches, form new collaborations, mentor junior scientists, and build professional networks in a supportive environment. The goals of the conference are to accelerate the exchange of interdisciplinary advances across different model systems, to promote technological innovations in the field, and deepen our understanding of neural crest cells and cranial placodes at genomic, transcriptomic and proteomic levels. Recent advances in generating neural crest cell and placode derivatives from human stem cells have major implications for our understanding of vertebrate development and evolution, the pathogenesis of congenital disorders and the promise of tissue engineering in regenerative medicine.

项目摘要神经rest细胞和颅骨位置具有进化和胚胎的起源，是基本的对脊椎动物发育，进化和疾病的重要性。它们一起形成了颅感神经节，但是单独产生了各种各样的细胞类型和组织。神经rest细胞形成头部和脸部的大部分骨头，软骨和结缔组织，产生牙本质牙齿，睫状肌肉和眼睛的角膜内皮，心肌细胞和心脏的主动脉肺间隔，肾上腺中的铬蛋白细胞，皮肤中的色素细胞，all as 周围神经胶质，周围自主神经和肠神经元，以及大多数周围的体感神经元。位置形成感觉受体，传入的神经神经和支持细胞的支撑细胞器官（鼻子，内耳，侧线系统），配对的眼睛的镜片，颅感（三叉神经）神经元和内脏感官（e骨）神经元，从心脏传递各种信息，肠道和其他内脏器官以及味蕾以及内分泌腺霍苯甲分析，对生育能力和稳态。神经rest细胞和颅骨位置提供了研究细胞和组织诱导的实验范例，干细胞多能力，模式，形态发生，起伏，上皮 - 间质转变，迁移和分化。神经rest细胞和位置是脊椎动物进化的代名词，并且缺陷它们的发展是广泛的出生缺陷和疾病，包括颅面畸形，心脏和胃肠道异常，感觉缺陷，异常生理功能和癌症。此GRC和GRS在神经rest细胞和颅骨上的GRS汇集了一组不同的领先科学家从事神经rest细胞和Placode生物学的各个方面的工作。会议提供了机会目前未发表的数据和新颖方法，组成新的合作，导师初级科学家并建立在支持环境中的专业网络。会议的目标是加速交换不同模型系统跨学科进步，以促进技术创新该领域，加深我们对基因组，转录组上神经rest细胞和颅骨位置的理解和蛋白质组学水平。从人类产生神经rest细胞和位置衍生物的最新进展干细胞对我们对脊椎动物发育和进化的理解具有重要意义先天性疾病的发病机理和再生医学中组织工程的承诺。