Center for Molecular Epidemiology

分子流行病学中心

• 批准号: 10630465
• 负责人: MARGARET Rita KARAGAS
• 金额: $ 123.08万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2028-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10630465
• 关键词: Acceleration; Achievement; Address; Award; Biomedical Research; Centers of Research Excellence; Collaborations; Communities; Consensus; Core Facility; Department chair; Disease; Disease Pathway; Early Intervention; Early identification; Endowment; Ensure; Epidemiologist; Epidemiology; Etiology; Evaluation; Extramural Activities; Faculty; Faculty Recruitment; Fostering; Funding; Future; Grant; Health; Health Personnel; Household; Human; Influentials; Infrastructure; Institution; International; Investigation; Investments; Joints; Leadership; Life Cycle Stages; Mentors; Mentorship; Methods; Molecular; Molecular Epidemiology; New England; Pathogenesis; Pediatric cohort; Peer Review; Phase; Pilot Projects; Policies; Population; Positioning Attribute; Prevention strategy; Principal Investigator; Productivity; Public Health; Publications; Research; Research Infrastructure; Research Personnel; Resources; Schools; Science; Scientific Advances and Accomplishments; Scientist; Services; Strategic Planning; Strategic vision; Structure; Talents; Technology; Training; Trustees; United States National Institutes of Health; biobank; biomedical scientist; burden of illness; career; career development; clinical practice; college; empowerment; forging; health equity promotion; health inequalities; human disease; indexing; innovation; interest; medical schools; member; molecular dynamics; multidisciplinary; next generation; prevent; programs; recruit; research and development; success; tool

ABSTRACT The field of epidemiology has gained increasing prominence in the research community and became a household word in 2020. Epidemiology provides the tools to uncover the underlying causes of human illness and to, in turn, inform clinical practice and preventive strategies, advise policy and regulatory actions, and move scientific advancements forward. In Phases I and II, our Centers of Biomedical Research Excellence (COBRE) Center for Molecular Epidemiology at Dartmouth has effectively advanced research in the field. As the only Center for molecular epidemiology in northern New England and one of the only COBRE programs with this focus nationally, we have successfully recruited and mentored the next generation of independent early career investigators. We further supported established investigators to enlarge their research programs, form new collaborations and integrate the latest biomedical discoveries, innovations, and methods. In doing so, we dramatically grew our research productivity and grant portfolio, as evidenced by the steep rise in the number of publications, presentations, and grants awarded since the inception of our COBRE Center. As part of achieving sustainability, we formed a new Department of Epidemiology and developed innovative cross- disciplinary training grants. Our cohesive Center brings together talented investigators focusing on 1) applying new scientific discoveries and technologies to address major human health concerns, 2) identifying early indicators of disease pathogenesis, and 3) exploring common pathways of disease etiology and progression in human populations, including those related to health inequities. In this Phase III application, we will progress our molecular epidemiology research infrastructure forward to full independence and sustainability. Specifically, we will 1) evolve a state-of-the-art Biorepository and Biospecimen Resource Facility Core that supplies the critical services responsive to the ongoing and future needs of biomedical scientists, 2) expand the pipeline of talented, diverse molecular epidemiologists, and provide the requisite mentorship, career development, and research resources to cultivate cutting-edge research and make investigators competitive for NIH funding, and 3) enhance the governance structure, implementation approaches, stakeholder engagement, and evaluation that will strengthen our Center’s impact, promote its strategic vision, and forge ties with regional and national partners. Our success in Phases I and II, combined with strong institutional support, positions us to serve as a vital resource in molecular epidemiology for Northern New England, for COBRE and IDeA Networks of Biomedical Research Excellence (INBRE) programs, and more broadly.

抽象的 流行病学领域在研究界越来越重要，并成为一个 2020年的家喻户晓。流行病学提供了揭示人类疾病根本原因的工具 反过来，为临床实践和预防策略，咨询政策和监管行动提供信息，以及 向前发展科学进步。在第I和II阶段，我们的生物医学研究中心卓越中心 （柯布雷）达特茅斯分子流行病学中心在该领域有效地进行了先进的研究。作为 新英格兰北部唯一的分子流行病学中心，也是唯一的鞋垫计划之一 在全国范围内，我们已经成功招募并修改了下一代独立 早期职业调查员。我们进一步支持已建立的研究人员扩大其研究计划， 组成新的合作，并整合最新的生物医学发现，创新和方法。这样做， 我们急剧提高了研究生产力和授予投资组合，这证明了钢的钢 自从我们的鞋匠中心成立以来，授予的出版物，演讲和赠款数量。作为一部分 为了实现可持续性，我们成立了一个新的流行病学系，并开发了创新的跨界 纪律培训补助金。 我们的凝聚力中心汇集了专注于1）应用新科学发现的才华横溢的调查员 以及解决主要人类健康问题的技术，2）确定疾病的早期指标 发病机理和3）探索人群中疾病病因和进展的常见途径， 包括与健康不平等有关的人。在此阶段III应用中，我们将进步我们的分子 流行病学研究基础设施前进到完全独立性和可持续性。具体来说，我们将1） 进化提供至关重要的最先进的生物座位和生物测量资源设施核心 响应生物医学科学家的持续和未来需求的服务，2）扩大管道 才华横溢的分子流行病学家，并提供必要的心态，职业发展和 研究资源以培养尖端研究并使研究人员对NIH资金有竞争力，以及 3）增强治理结构，实施方法，利益相关者的参与和评估 这将加强我们中心的影响，促进其战略愿景，并与地区和国家建立联系 合作伙伴。我们在第I和II阶段的成功，再加上强大的机构支持，使我们成为一个 新英格兰北部分子流行病学的重要资源 生物医学研究卓越（INBRE）计划，更广泛。