A prospective study of critical environmental exposures in formative early life that impact lifelong health in rural US children: the New Hampshire Birth Cohort Study

一项关于影响美国农村儿童终身健康的生命形成早期关键环境暴露的前瞻性研究：新罕布什尔州出生队列研究

• 批准号: 10474633
• 负责人: MARGARET Rita KARAGAS
• 金额: $ 525.52万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10474633
• 关键词: 3 year old; 5 year old; Accelerometer; Address; Age; Archives; Asthma; Behavioral; Bioinformatics; Biological; Biological Markers; Birth; Blood; Blood specimen; Cells; Cesarean section; Child; Child Development; Child Health; Childhood; Clinical; Cohort Studies; Complex; Conceptions; Cryopreservation; DNA; DNA Methylation; Data; Data Collection; Data Element; Diagnosis; Elements; Enrollment; Environmental Exposure; Environmental Impact; Environmental Pollution; Environmental Risk Factor; Exposure to; Feces; First Pregnancy Trimester; Flow Cytometry; Gene Expression; Growth; Hair; Health; Home environment; Hospitalization; Household Air Pollution; Human; Human Milk; Infant; Intervention; Interview; Intestines; Knowledge; Laboratories; Life; Lymphocyte; Measurement; Meconium; Mediator of activation protein; Medical; Medical Records; Metals; Methodology; Monitor; Mothers; National Institute of Environmental Health Sciences; New Hampshire; Non-Prescription Drugs; Obesity; Operative Surgical Procedures; Outcome; Outcome Assessment; Participant; Pediatric cohort; Persons; Phase; Physical activity; Physical environment; Placenta; Pregnancy; Prospective Studies; Questionnaires; Records; Research; Respiratory Tract Infections; Role; Rural; Salivary; Sampling; Self Administration; Structure of nail of toe; Techniques; Technology; Testing; Time; Tooth structure; Toxic Environmental Substances; Umbilical Cord Blood; Urine; Ursidae Family; Validation; Water; Water Supply; Wood stove; air monitoring; biobank; built environment; climate change; cohort; data acquisition; detector; drinking; drinking water; early life exposure; experience; feasibility testing; fetal; follow-up; food environment; gut microbiome; improved; in utero; indoor air; innovation; lifestyle factors; metabolomics; microbiome; microbiome sequencing; neurodevelopment; novel; prenatal; pulmonary function; respiratory; respiratory health; rural area; rural setting; sample collection; sex; sleep pattern; social; stool sample; urinary; vaccine response; wood smoke

Project Summary/Abstract: Major gaps exist in our knowledge of the health impacts of widespread and dramatically expanding exposures among children in the US. Children from rural regions are particularly understudied, but may experience higher exposures to contaminants by drinking unregulated water; from household air pollution from wood stoves; and consequent to their rural and changing landscape (e.g., from climate change). As part of this ECHO Pediatric Cohorts application, we propose to take advantage of the NIEHS/EPA supported New Hampshire Birth Cohort Study (NHBCS): a rural, ongoing pregnancy cohort that has accrued over 1,500 maternal-infant dyads. By the beginning of the UH3 phase of this application, the anticipated cohort size will be 2,000, and as part of this ECHO Pediatric Cohorts application, accrual will be extended to 3,000 maternal-infant pairs. Clinical outcomes are being ascertained from interval interviews, questionnaires, medical records, in-person assessments and laboratory tests. The study has archived environmental (tap water and indoor air) and biological samples collected during pregnancy (maternal blood, urine and hair), as well as biological samples acquired at birth (infant cord blood, placenta and meconium) and during childhood (urine, blood, buccal cells, breast milk, toenails and stool). With support of a state-of-the-art biorepository, the ability to utilize these samples for a wide range of downstream analyses has been demonstrated, e.g., for DNA methylation arrays, gene expression, microbiome sequencing, metabolomics and flow cytometry. For the current application, emerging hypotheses of concern will be addressed by: (1) leveraging the extant NHBCS to perform targeted and unsupervised metabolomic analyses of 1,000 cord blood samples and 250 paired maternal gestational blood samples, and assess associations with exposures, early growth, and the infant microbiome; (2) expanding data acquisition, sample collection and participant accrual to more precisely characterize exposures and timing of early life exposures by obtaining urinary metallome and metal metabolomic measurements, and exposome monitoring data from the first trimester of pregnancy, along with spatial analysis of naturally shed teeth for prenatal metal concentrations; and (3) extending follow-up to identify childhood exposures to contaminants (through biomarkers and personal monitors); the home environment (e.g., physical activity and sleep patterns, food environment, green, blue and white space, and media usage); and medical exposures (e.g., prescription and non-prescription medications and surgical interventions) that relate to fetal and childhood growth, obesity at age 3 years, respiratory infection and asthma by age 5 years, and pulmonary function data at age 7.5 years. Additionally, novel statistical approaches will be used to determine the role of the intestinal and salivary microbiome as mediators of these effects. The collective expertise, methodologies, data, samples and preliminary results from this study will contribute to the planning of the broader ECHO Pediatric Cohorts initiative in order to advance our understanding of the environmental factors early in life that drive childhood and lifelong health.

项目摘要/摘要：我们对广泛的健康影响的知识存在主要差距 美国儿童之间的暴露幅度急剧扩大。来自农村地区的孩子尤其是 研究了，但可能会通过喝不管制的水对污染物的暴露率更高。从 木炉受到的家庭空气污染；并导致他们的农村和不断变化的景观（例如 气候变化）。作为此回声儿科同伙申请的一部分，我们建议利用 NIEHS/EPA支持新罕布什尔州出生队列研究（NHBCS）：一个乡村，正在进行的怀孕队列 已积累了1,500多个产妇二元组。到本应用程序的UH3阶段的开始， 预期的队列尺寸将为2,000，作为此Echo儿科同伙申请的一部分，应计入 延伸到3,000对孕产妇。从间隔访谈中确定临床结果， 问卷，医疗记录，面对面评估和实验室测试。该研究已存档 妊娠期间收集的环境（自来水和室内空气）和生物样品（母血， 尿液和头发）以及出生时获得的生物样品（婴儿脐带血，胎盘和胎粪）和 在童年时期（尿液，血液，颊细胞，母乳，脚趾甲和粪便）。在最先进的支持下 生物座席，将这些样品用于广泛的下游分析的能力已有 例如，用于DNA甲基化阵列，基因表达，微生物组测序，代谢组学和 流式细胞仪。对于当前申请，新兴的关注假设将通过：（1）解决。 利用现有的NHBC进行1,000索脐带血的针对性和无监督的代谢组分分析 样品和250个配对的母体妊娠血液样本，并评估与暴露的关联，早期 生长和婴儿微生物组； （2）扩大数据获取，样本收集和参与者应计为 更精确地表征了通过获取尿泌尿金属和 金属代谢组测量和沿妊娠头三个月的杂物体监测数据沿 通过对产前金属浓度的自然脱落牙齿的空间分析； （3）将后续行动扩展到 通过生物标志物和个人监视器来确定儿童时期暴露于污染物；家 环境（例如，体育锻炼和睡眠方式，食物环境，绿色，蓝色和白色空间，以及 媒体用法）；和医疗暴露（例如，处方和非处方药以及手术 干预措施）与胎儿和儿童期生长，3岁时的肥胖症，呼吸道感染和哮喘有关 到5岁的年龄和7.5岁的肺功能数据。此外，新颖的统计方法将是 用于确定肠道和唾液微生物组作为这些作用的介体的作用。这 集体专业知识，方法，数据，样本和本研究的初步结果将有助于 为了促进我们的理解 生命早期的环境因素促进了童年和终身健康。

项目成果

Health Behavior Changes during the COVID-19 Pandemic: A Longitudinal Analysis among Children.

• DOI: 10.3390/ijerph19159220
• 发表时间: 2022-07-28
• 期刊: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
• 作者: Bekelman, Traci A.;Dong, Yanan;Elliott, Amy J.;Ferrara, Assiamira;Friesen, Kaylyn;Galarce, Maren;Gilbert-Diamond, Diane;Glueck, Deborah H.;Hedderson, Monique M.;Hockett, Christine W.;Karagas, Margaret R.;Knapp, Emily A.;Lucchini, Maristella;McDonald, Julia C.;Sauder, Katherine A.;Dabelea, Dana
• 通讯作者: Dabelea, Dana

Trends in Screen Time Use Among Children During the COVID-19 Pandemic, July 2019 Through August 2021.

• DOI: 10.1001/jamanetworkopen.2022.56157
• 发表时间: 2023-02-01
• 期刊: JAMA NETWORK OPEN
• 影响因子: 13.8
• 作者: Hedderson, Monique M.;Bekelman, Traci A.;Li, Mingyi;Knapp, Emily A.;Palmore, Meredith;Dong, Yanan;Elliott, Amy J.;Friedman, Chloe;Galarce, Maren;Gilbert-Diamond, Diane;Glueck, Deborah;Hockett, Christine W.;Lucchini, Maristella;Mcdonald, Julia;Sauder, Katherine;Zhu, Yeyi;Karagas, Margaret R.;Dabelea, Dana;Ferrara, Assiamira
• 通讯作者: Ferrara, Assiamira

Bronchiolitis hospitalizations in rural New England: clues to disease prevention.

• DOI: 10.1177/20499361221099447
• 发表时间: 2022-01
• 期刊: THERAPEUTIC ADVANCES IN INFECTIOUS DISEASE
• 影响因子: 5.7
• 作者: Wright, Peter F.;Hoen, Anne G.;Jarvis, J. Dean;Zens, Michael S.;Dade, Erika F.;Karagas, Margaret R.;Taube, Juliana;Brickley, Elizabeth B.
• 通讯作者: Brickley, Elizabeth B.

Children's Particulate Matter Exposure Characterization as Part of the New Hampshire Birth Cohort Study.

• DOI: 10.3390/ijerph182212109
• 发表时间: 2021-11-18
• 期刊: International journal of environmental research and public health
• 作者: Thornburg J;Halchenko Y;McCombs M;Siripanichgon N;Dowell E;Cho SH;Egner J;Sayarath V;Karagas MR
• 通讯作者: Karagas MR