The Norwegian Mother And Child Study: Environmental Specimen Collection

挪威母子研究：环境样本收集

• 批准号: 7734433
• 负责人: Matthew Longnecker
• 金额: $ 16.7万
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7734433
• 关键词: Autistic Disorder; Autoantibodies; Biological; Birth; Blood; Cerebral Palsy; Chemicals; Child; Cohort Studies; Collection; Congenital Abnormality; Data Collection; Development; Dietary intake; Disease; Enrollment; Environmental Exposure; Environmental Pollution; Etiology; Fathers; Finding by Cause; Folate; Future; Genes; Gestational Diabetes; Growth; Health; Human; Infant; Laboratories; Measures; Medical; Metabolic; Mothers; Organophosphates; Outcome; Paper; Pesticides; Phase; Physical activity; Predisposition; Pregnancy; Preparation; Protocols documentation; Publishing; Purpose; Questionnaires; Recruitment Activity; Reporting; Research Personnel; Resources; Risk; Risk Factors; Scientist; Serum; Specimen; System; Testing; Time; Trace Elements; Urine; Week; Whole Blood; Woman; Work; Writing; base; bisphenol A; cleft lip and palate; disorder risk; falls; fetal; folate-binding protein; in utero; neurodevelopment; pesticide exposure; phthalate; phthalates; sample collection; transmission process

The Norwegian Mother and Child Cohort Study (MoBa) is an ongoing pregnancy cohort study, with the aim of enrolling 110,000 pregnancies by 2008. The study is based on questionnaires completed by the mother and father, and biological specimens are collected from the mother, father and child. The main purpose of the study is to find causes of diseases. NIEHS is providing partial support for the study, and in 2002 expanded the data collection protocol to include collection of more biologic specimens from the mothers during the 17th week of pregnancy (additional serum, a specimen of whole blood collected in a trace-element free container, and urine). These specimens will enhance the ability to examine the relation of environmental exposures in relation to various health outcomes in the children and their mothers. As of April 30, 2008, 72,227 subjects had provided blood and urine that was collected in conjunction with NIEHS. We expect about 8,000 additional subjects to be recruited before enrollment closes. In the past year, in preparation for a new study in MoBa, we published a paper on the ability of various laboratories to measure a group of environmental contaminants that we plan to study, perfluorinated alkyls. We have also nearly completed work on a report about levels of 3 types of environmental contaminants in the urine of MoBa mothers: organophosphate pesticides, bisphenol A, and phthalates. The levels of bisphenol A and organophosphate pesticide metabolites were higher than in the U.S., making the MoBa resource an especially valuable setting for studies of associated health outcomes. Another activity in the past year was to add to the MoBa protocol the collection additional urine specimens in pregnancy, at weeks 23 and 29, for a subset of women. We anticipate that by the fall of this year about 600 women will have a complete set of three urine specimens from pregnancy. At this time we are putting in place a protocol to measure the levels of metabolites of organophosphate pesticides and bisphenol A in these specimens, to determine how reproducibile the levels are. This information will help us plan future studies on associations with health outcomes. Because the study is still in the subject enrollment phase, writing of scientific reports is still relatively limited. At NIEHS, we are developing studies that will be nested within MoBa. The current list of planned studies includes: Pregnancy Serum Levels of Perfluoroalkyl Chemicals in Relation to Infant Growth, Risk Factors for Cleft Lip and Palate, A Search for the Non-mendelian Transmission of Human Genes, Mother's Physical Activity During Pregnancy and Fetal Loss, Dietary Intake and Gestational Diabetes, Physical Activity in Pregnancy and Infant Neurodevelopment, Maternal Autoantibodies against Folate Receptors as a Risk Factor for Folate Sensitive Birth Defects, Organophosphate Pesticide Exposure and Risk of Autism, and the Etiology of Cerebral Palsy.

挪威母婴队列研究 (MoBa) 是一项正在进行的妊娠队列研究，目标是到 2008 年招募 110,000 名孕妇。该研究以母亲和父亲填写的问卷为基础，并从母亲、父亲身上收集生物样本和孩子。研究的主要目的是寻找疾病的原因。 NIEHS 为这项研究提供部分支持，并于 2002 年扩大了数据收集方案，包括在怀孕第 17 周期间从母亲身上收集更多的生物样本（额外的血清，即在无微量元素的容器中收集的全血样本）和尿液）。 这些标本将增强检查环境暴露与儿童及其母亲的各种健康结果之间关系的能力。 截至 2008 年 4 月 30 日，已有 72,227 名受试者提供了与 NIEHS 联合收集的血液和尿液。 我们预计在招募结束前将再招募约 8,000 名受试者。 去年，为了准备 MoBa 的一项新研究，我们发表了一篇关于各个实验室测量我们计划研究的一组环境污染物（全氟化烷基）的能力的论文。 我们还即将完成一份关于 MoBa 母亲尿液中 3 种环境污染物含量的报告：有机磷农药、双酚 A 和邻苯二甲酸盐。 双酚 A 和有机磷农药代谢物的水平高于美国，这使得 MoBa 资源成为研究相关健康结果的特别有价值的环境。 去年的另一项活动是在 MoBa 方案中添加在怀孕第 23 周和第 29 周时为一部分女性收集额外的尿液样本。 我们预计，到今年秋季，大约 600 名女性将获得一套完整的三份怀孕尿液样本。 目前，我们正在制定一项方案来测量这些样本中有机磷农药和双酚 A 代谢物的水平，以确定这些水平的重现性。 这些信息将帮助我们规划未来与健康结果关联的研究。 由于该研究尚处于课题招募阶段，科学报告的撰写还比较有限。 在 NIEHS，我们正在开发将嵌套在 MoBa 中的研究。 当前计划的研究清单包括：全氟烷基化学品的妊娠血清水平与婴儿生长的关系、唇裂和腭裂的危险因素、人类基因的非孟德尔传播的探索、母亲在怀孕和胎儿丢失期间的体力活动、饮食摄入量和妊娠期糖尿病、妊娠期体力活动和婴儿神经发育、针对叶酸受体的母体自身抗体作为叶酸的危险因素敏感出生缺陷、有机磷农药暴露和自闭症风险以及脑瘫的病因学。