Effect Of Diet and Other Early Exposures on Child Health and Development

饮食和其他早期暴露对儿童健康和发育的影响

• 批准号: 8929729
• 负责人: Matthew Longnecker
• 金额: $ 7.61万
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8929729
• 关键词: Affect; Annual Reports; Area; Child Development; Child health care; Childhood; Chronic Disease; Cryptorchidism; Diet; Diethylstilbestrol; Exposure to; Fetal Development; Fetus; Gestational Diabetes; Hormones; Hypospadias; Metabolic; Obesity; Oral Contraceptives; Perinatal; Perinatal Exposure; Pregnancy; Pregnant Women; Publishing; Reporting; Research; Risk; Work; obesity in children; obesogen; offspring

Diet and other early exposures may affect child development and the risk of several chronic diseases, but additional research is needed. The current research described in this catch-all project comprises one project, described below. We examined the association of gestational diabetes with subsequent risk of hypospadias and cryptorchidism in offspring born in the Collaborative Perinatal Project. No association was found, which may be because the metabolic disturbances due to gestational diabetes occur after the period of fetal development when the fetus is most susceptible to environmental influences. A report was published. We examined in utero exposure to maternal pharmacologic hormone use in pregnancy in relation to obesity in childhood. Pregnant women who took diethylstilbestrol or oral contraceptives during specific periods of pregnancy were more likely to have obese children. The findings provide general support for the "obesogens" hypothesis. A report is in press.

饮食和其他早期暴露可能会影响儿童发育和几种慢性疾病的风险，但需要进行其他研究。 当前的所有项目中描述的当前研究包括一个项目，如下所述。 我们研究了妊娠糖尿病与随后在协作围产期项目中出生的后代中催化性和隐式术的风险的关联。 没有发现任何关联，这可能是因为胎儿发育后发生的胎儿糖尿病发生的代谢障碍发生，当时胎儿最容易受到环境影响。报告发表了。 我们检查了子宫对孕期孕期孕产妇药物激素使用的暴露。 在特定妊娠期间服用二乙基苯甲酸酯或口服避孕药的孕妇更有可能生育肥胖儿童。 这些发现为“肥胖者”假设提供了一般支持。 报告在印刷中。

项目成果

Pharmacologic sex hormones in pregnancy in relation to offspring obesity.

妊娠期药理学性激素与后代肥胖的关系。

• DOI: 10.1002/oby.20778
• 发表时间: 2014-11
• 期刊: OBESITY
• 影响因子: 6.9
• 作者: Jensen, Elizabeth T.;Longnecker, Matthew P.
• 通讯作者: Longnecker, Matthew P.

Meeting report: measuring endocrine-sensitive endpoints within the first years of life.

• DOI: 10.1289/ehp.11226
• 发表时间: 2008-07
• 期刊: ENVIRONMENTAL HEALTH PERSPECTIVES
• 影响因子: 10.4
• 作者: Arbuckle, Tye E.;Hauser, Russ;Swan, Shanna H.;Mao, Catherine S.;Longnecker, Matthew P.;Main, Katharina M.;Whyatt, Robin M.;Mendola, Pauline;Legrand, Melissa;Rovet, Joanne;Till, Christine;Wade, Mike;Jarrell, John;Matthews, Stephen;Van Vliet, Guy;Bornehag, Carl-Gustaf;Mieusset, Roger
• 通讯作者: Mieusset, Roger

Mother's age at menarche and offspring size.

• DOI: 10.1038/ijo.2010.104
• 发表时间: 2010-12
• 期刊: INTERNATIONAL JOURNAL OF OBESITY
• 影响因子: 4.9
• 作者: Basso, O.;Pennell, M. L.;Chen, A.;Longnecker, M. P.
• 通讯作者: Longnecker, M. P.

Nephrotoxicity, neurotoxicity, and mercury exposure among children with and without dental amalgam fillings.

• DOI: 10.1016/j.ijheh.2008.09.004
• 发表时间: 2009-07
• 期刊: INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
• 影响因子: 6
• 作者: Ye, Xibiao;Qian, Haojun;Xu, Peicheng;Zhu, Lin;Longnecker, Matthew P.;Fu, Hua
• 通讯作者: Fu, Hua