Effect Of Diet and Other Early Exposures on Child Health and Development

饮食和其他早期暴露对儿童健康和发育的影响

• 批准号: 8929729
• 负责人: Matthew Longnecker
• 金额: $ 7.61万
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8929729
• 关键词: Affect; Annual Reports; Area; Child Development; Child health care; Childhood; Chronic Disease; Cryptorchidism; Diet; Diethylstilbestrol; Exposure to; Fetal Development; Fetus; Gestational Diabetes; Hormones; Hypospadias; Metabolic; Obesity; Oral Contraceptives; Perinatal; Perinatal Exposure; Pregnancy; Pregnant Women; Publishing; Reporting; Research; Risk; Work; obesity in children; obesogen; offspring

Diet and other early exposures may affect child development and the risk of several chronic diseases, but additional research is needed. The current research described in this catch-all project comprises one project, described below. We examined the association of gestational diabetes with subsequent risk of hypospadias and cryptorchidism in offspring born in the Collaborative Perinatal Project. No association was found, which may be because the metabolic disturbances due to gestational diabetes occur after the period of fetal development when the fetus is most susceptible to environmental influences. A report was published. We examined in utero exposure to maternal pharmacologic hormone use in pregnancy in relation to obesity in childhood. Pregnant women who took diethylstilbestrol or oral contraceptives during specific periods of pregnancy were more likely to have obese children. The findings provide general support for the "obesogens" hypothesis. A report is in press.

饮食和其他早期暴露可能会影响儿童发育和几种慢性疾病的风险，但还需要进行更多研究。 这一包罗万象的项目中描述的当前研究包括一个项目，如下所述。 我们研究了妊娠期糖尿病与围产期合作项目中出生的后代随后发生尿道下裂和隐睾风险的关系。 没有发现任何关联，这可能是因为妊娠糖尿病引起的代谢紊乱发生在胎儿发育期之后，此时胎儿最容易受到环境影响。发表了一份报告。 我们研究了妊娠期子宫内暴露于母体药理激素使用与儿童肥胖之间的关系。 在怀孕特定时期服用己烯雌酚或口服避孕药的孕妇更有可能生出肥胖的孩子。 这些发现为“致肥胖者”假说提供了总体支持。 一份报告正在出版中。

项目成果

Pharmacologic sex hormones in pregnancy in relation to offspring obesity.

妊娠期药理学性激素与后代肥胖的关系。

• DOI: 10.1002/oby.20778
• 发表时间: 2014-11
• 期刊: OBESITY
• 影响因子: 6.9
• 作者: Jensen, Elizabeth T.;Longnecker, Matthew P.
• 通讯作者: Longnecker, Matthew P.

Meeting report: measuring endocrine-sensitive endpoints within the first years of life.

• DOI: 10.1289/ehp.11226
• 发表时间: 2008-07
• 期刊: ENVIRONMENTAL HEALTH PERSPECTIVES
• 影响因子: 10.4
• 作者: Arbuckle, Tye E.;Hauser, Russ;Swan, Shanna H.;Mao, Catherine S.;Longnecker, Matthew P.;Main, Katharina M.;Whyatt, Robin M.;Mendola, Pauline;Legrand, Melissa;Rovet, Joanne;Till, Christine;Wade, Mike;Jarrell, John;Matthews, Stephen;Van Vliet, Guy;Bornehag, Carl-Gustaf;Mieusset, Roger
• 通讯作者: Mieusset, Roger

Nephrotoxicity, neurotoxicity, and mercury exposure among children with and without dental amalgam fillings.

• DOI: 10.1016/j.ijheh.2008.09.004
• 发表时间: 2009-07
• 期刊: INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
• 影响因子: 6
• 作者: Ye, Xibiao;Qian, Haojun;Xu, Peicheng;Zhu, Lin;Longnecker, Matthew P.;Fu, Hua
• 通讯作者: Fu, Hua

Mother's age at menarche and offspring size.

• DOI: 10.1038/ijo.2010.104
• 发表时间: 2010-12
• 期刊: INTERNATIONAL JOURNAL OF OBESITY
• 影响因子: 4.9
• 作者: Basso, O.;Pennell, M. L.;Chen, A.;Longnecker, M. P.
• 通讯作者: Longnecker, M. P.