The Norwegian Mother And Child Study: Environmental Specimen Collection

挪威母子研究：环境样本收集

• 批准号: 8336544
• 负责人: Matthew Longnecker
• 金额: $ 74.15万
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8336544
• 关键词: Autistic Disorder; Biological; Birth; Blood; Chemistry; Child; Cohort Studies; Collection; Data; Data Collection; Development; Dietary intake; Disease; Enrollment; Environmental Exposure; Exposure to; Fathers; Finding by Cause; Future; Genes; Gestational Diabetes; Health; Human; Infant; Journals; Manuscripts; Measures; Medical; Metabolic; Metabolic syndrome; Morphologic artifacts; Mothers; National Institute of Environmental Health Sciences; Organophosphates; Outcome; Paper; Perinatal Exposure; Pesticides; Phase; Physical activity; Predisposition; Pregnancy; Protocols documentation; Publishing; Questionnaires; Reporting; Reproducibility; Research Design; Research Personnel; Risk; Risk Factors; Scientist; Series; Serum; Specimen; Spontaneous abortion; System; Testing; Time; Tobacco smoke; Trace Elements; Urine; Whole Blood; Woman; Writing; base; bisphenol A; cleft lip and palate; cohort; disorder risk; fetal; in utero; neurodevelopment; pesticide exposure; sample collection; stillbirth; transmission process

The Norwegian Mother and Child Cohort Study (MoBa) is an ongoing prebirth cohort study. Enrollment was completed in 2008 resulting in 106,980 pregnancies in the study. The study is based on questionnaires completed by the mother and father, and biological specimens are collected from the mother, father and child. The main purpose of the study is to find causes of diseases. NIEHS is providing partial support for the study, and in 2002 expanded the data collection protocol to include collection of more biologic specimens from the mothers during the 17th week of pregnancy (additional serum, a specimen of whole blood collected in a trace-element free container, and urine). These specimens will enhance the ability to examine the relation of environmental exposures in relation to various health outcomes in the children and their mothers. As of April 30, 2009, 77,104 subjects had provided blood and urine that was collected in conjunction with NIEHS. In the past year, using the MoBa data, we have conducted a series of studies of health effects of in utero exposure to tobacco smoke. One report, on the association with miscarriage and stillbirth was published; no association was found. A second report, on the reproducibility of reported in utero exposure to tobacco smoke, was also published; the results show the reports of exposure are highly reproducible. We are now examining in utero exposure to tobacco smoke in relation to components of the metabolic syndrome and find evidence of an association. One manuscript reporting this finding has been revised and resubmitted to a journal, and a second manusecript is ready to be submitted after the first one is accepted. We added to the MoBa protocol the collection additional urine specimens in pregnancy, at weeks 23 and 29, for a subset of women. 690 women have a complete set of three urine specimens from pregnancy. We wrote a protocol to measure the levels of metabolites of organophosphate pesticides and bisphenol A in these specimens, to determine how reproducibile the levels are; the specimens are now being analyzed. This information will help us plan future studies on associations with health outcomes. We also have been studying perfluorinated alklys in relation to time-to-pregnancy and birthweight among women in the MoBa cohort. The association with increased time-to-pregnancy reported by others was also present in the MoBa data but appears to be due to an artifact of the study design; our manuscript on this has been revised and resubmitted to a journal. A manuscript on the association of perfluorinated compounds with birthweight also received favorable reviews from a journal and is being revised. We plan at least two other papers based on these data; one on values of clincial chemistry paramters in relation to perfluorinated compound levels, and one on determinants of blood levels. Because the study is in a relatively early phase, the number of scientific reports is still limited. At NIEHS, we are developing several studies that will be nested within MoBa. A list of the studies currently planed includes: Risk Factors for Cleft Lip and Palate, A Search for the Non-mendelian Transmission of Human Genes, Mother's Physical Activity During Pregnancy and Fetal Loss, Dietary Intake and Gestational Diabetes, Physical Activity in Pregnancy and Infant Neurodevelopment, Organophosphate Pesticide Exposure and Risk of Autism, and additional studies on perfluorinated compound exposure and health.

挪威母亲和儿童队列研究（MOBA）是一项持续的出生前研究。 在2008年，入学人数完成，在研究中导致106,980例怀孕。该研究基于父母完成的问卷，并从母亲，父亲和孩子那里收集生物标本。该研究的主要目的是找到疾病的原因。 NIEHS正在为这项研究提供部分支持，并在2002年扩大了数据收集方案，包括在怀孕的第17周内收集来自母亲的更多生物标本（额外的血清，无微量元素集装箱中收集的全血标本和尿液）。 这些标本将增强检查与儿童及其母亲各种健康结果有关的环境暴露关系的能力。 截至2009年4月30日，已有77,104名受试者提供了与Niehs结合的血液和尿液。 在过去的一年中，使用MOBA数据，我们进行了一系列有关子宫内暴露于烟草烟雾的健康影响的研究。 一份关于与流产和死产的关联的报告；找不到关联。 第二份报告，关于子宫烟雾烟雾烟雾中报告的可重复性，也发表了；结果表明，暴露的报告高度可重复。 现在，我们正在研究与代谢综合征组成部分有关的子宫内烟草烟雾的暴露，并找到了关联的证据。 一项报告该发现的手稿已被修订并重新提交到日记帐中，并且在接受第一个手术后准备提交第二次手法。 我们在MOBA方案中添加了收集在第23和29周的怀孕中的其他尿液标本，该标本是女性的一部分。 690名妇女在怀孕中有一组完整的三个尿液标本。 我们编写了一项方案，以测量这些标本中有机磷酸盐农药和双酚A的代谢产物水平，以确定水平的再生能力。现在正在分析样品。 这些信息将帮助我们计划有关与健康成果的关联的未来研究。 我们还一直在研究MOBA队列中女性的孕妇和出生体重的全氟化碱。 MOBA数据中也存在与其他人报告的时间增加的相关性，但似乎是由于研究设计的伪像。我们对此的手稿已被修订和重新提交日记。 关于全氟化化合物与出生体重协会协会的手稿也从期刊中获得了有利的评论，并正在修订。 我们至少根据这些数据计划了另外两篇论文。一个关于与全氟化化合物水平相关的细胞化学参数值，另一个是关于血液水平的决定因素。 由于该研究处于相对较早的阶段，因此科学报告的数量仍然有限。 在NIEHS，我们正在开发几项将嵌套在MOBA内的研究。 当前计划的研究清单包括：唇唇和唇酸的危险因素，寻找人类基因的非孟德尔式传播，母亲在怀孕期间的身体活动和胎儿丧失，饮食摄入和妊娠糖尿病，妊娠的体育锻炼以及婴儿神经发育，有机磷酸盐的载体量，自动含量以及对全身的风险以及对健康的曝光以及健康的曝光。