The Norwegian Mother And Child Study: Environmental Specimen Collection

挪威母子研究：环境样本收集

• 批准号: 8336544
• 负责人: Matthew Longnecker
• 金额: $ 74.15万
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8336544
• 关键词: Autistic Disorder; Biological; Birth; Blood; Chemistry; Child; Cohort Studies; Collection; Data; Data Collection; Development; Dietary intake; Disease; Enrollment; Environmental Exposure; Exposure to; Fathers; Finding by Cause; Future; Genes; Gestational Diabetes; Health; Human; Infant; Journals; Manuscripts; Measures; Medical; Metabolic; Metabolic syndrome; Morphologic artifacts; Mothers; National Institute of Environmental Health Sciences; Organophosphates; Outcome; Paper; Perinatal Exposure; Pesticides; Phase; Physical activity; Predisposition; Pregnancy; Protocols documentation; Publishing; Questionnaires; Reporting; Reproducibility; Research Design; Research Personnel; Risk; Risk Factors; Scientist; Series; Serum; Specimen; Spontaneous abortion; System; Testing; Time; Tobacco smoke; Trace Elements; Urine; Whole Blood; Woman; Writing; base; bisphenol A; cleft lip and palate; cohort; disorder risk; fetal; in utero; neurodevelopment; pesticide exposure; sample collection; stillbirth; transmission process

The Norwegian Mother and Child Cohort Study (MoBa) is an ongoing prebirth cohort study. Enrollment was completed in 2008 resulting in 106,980 pregnancies in the study. The study is based on questionnaires completed by the mother and father, and biological specimens are collected from the mother, father and child. The main purpose of the study is to find causes of diseases. NIEHS is providing partial support for the study, and in 2002 expanded the data collection protocol to include collection of more biologic specimens from the mothers during the 17th week of pregnancy (additional serum, a specimen of whole blood collected in a trace-element free container, and urine). These specimens will enhance the ability to examine the relation of environmental exposures in relation to various health outcomes in the children and their mothers. As of April 30, 2009, 77,104 subjects had provided blood and urine that was collected in conjunction with NIEHS. In the past year, using the MoBa data, we have conducted a series of studies of health effects of in utero exposure to tobacco smoke. One report, on the association with miscarriage and stillbirth was published; no association was found. A second report, on the reproducibility of reported in utero exposure to tobacco smoke, was also published; the results show the reports of exposure are highly reproducible. We are now examining in utero exposure to tobacco smoke in relation to components of the metabolic syndrome and find evidence of an association. One manuscript reporting this finding has been revised and resubmitted to a journal, and a second manusecript is ready to be submitted after the first one is accepted. We added to the MoBa protocol the collection additional urine specimens in pregnancy, at weeks 23 and 29, for a subset of women. 690 women have a complete set of three urine specimens from pregnancy. We wrote a protocol to measure the levels of metabolites of organophosphate pesticides and bisphenol A in these specimens, to determine how reproducibile the levels are; the specimens are now being analyzed. This information will help us plan future studies on associations with health outcomes. We also have been studying perfluorinated alklys in relation to time-to-pregnancy and birthweight among women in the MoBa cohort. The association with increased time-to-pregnancy reported by others was also present in the MoBa data but appears to be due to an artifact of the study design; our manuscript on this has been revised and resubmitted to a journal. A manuscript on the association of perfluorinated compounds with birthweight also received favorable reviews from a journal and is being revised. We plan at least two other papers based on these data; one on values of clincial chemistry paramters in relation to perfluorinated compound levels, and one on determinants of blood levels. Because the study is in a relatively early phase, the number of scientific reports is still limited. At NIEHS, we are developing several studies that will be nested within MoBa. A list of the studies currently planed includes: Risk Factors for Cleft Lip and Palate, A Search for the Non-mendelian Transmission of Human Genes, Mother's Physical Activity During Pregnancy and Fetal Loss, Dietary Intake and Gestational Diabetes, Physical Activity in Pregnancy and Infant Neurodevelopment, Organophosphate Pesticide Exposure and Risk of Autism, and additional studies on perfluorinated compound exposure and health.

挪威母婴队列研究 (MoBa) 是一项正在进行的产前队列研究。 该研究于 2008 年完成入组，共有 106,980 名孕妇怀孕。该研究以母亲和父亲填写的问卷为基础，并从母亲、父亲和孩子身上采集生物样本。研究的主要目的是寻找疾病的原因。 NIEHS 为这项研究提供部分支持，并于 2002 年扩大了数据收集方案，包括在怀孕第 17 周期间从母亲身上收集更多的生物样本（额外的血清，即在无微量元素的容器中收集的全血样本）和尿液）。 这些标本将增强检查环境暴露与儿童及其母亲的各种健康结果之间关系的能力。 截至 2009 年 4 月 30 日，已有 77,104 名受试者提供了与 NIEHS 联合收集的血液和尿液。 去年，我们利用 MoBa 数据进行了一系列关于子宫内接触烟草烟雾对健康影响的研究。 发表了一份关于流产和死产关联的报告；没有找到关联。 还发布了第二份关于子宫内烟草烟雾暴露报告的可重复性的报告；结果表明暴露报告具有高度可重复性。 我们现在正在检查子宫内烟草烟雾暴露与代谢综合征成分的关系，并找到相关证据。 报告这一发现的一份手稿已被修改并重新提交给期刊，在第一份手稿被接受后，第二份手稿已准备好提交。 我们在 MoBa 方案中添加了在怀孕第 23 周和第 29 周时为一部分女性收集额外尿液样本的内容。 690 名女性拥有一套完整的三份怀孕尿液样本。 我们编写了一份方案来测量这些样本中有机磷农药和双酚 A 代谢物的水平，以确定这些水平的重现性；目前正在对样本进行分析。 这些信息将帮助我们规划未来与健康结果关联的研究。 我们还一直在研究全氟化烷基与 MoBa 队列中女性的怀孕时间和出生体重的关系。 其他人报告的与怀孕时间延长的关联也存在于 MoBa 数据中，但似乎是由于研究设计的人为因素造成的；我们对此的手稿已被修改并重新提交给期刊。 一篇关于全氟化合物与出生体重之间关系的手稿也获得了一家期刊的好评，目前正在修订中。 我们根据这些数据计划至少另外两篇论文；一份关于与全氟化合物水平相关的临床化学参数值，一份关于血液水平的决定因素。 由于该研究还处于相对早期阶段，科学报告的数量仍然有限。 在 NIEHS，我们正在开发几项将嵌套在 MoBa 中的研究。 目前计划的研究清单包括：唇裂和腭裂的危险因素、人类基因的非孟德尔传播的探索、母亲在怀孕和流产期间的体力活动、膳食摄入量和妊娠期糖尿病、怀孕和婴儿期间的体力活动神经发育、有机磷农药暴露和自闭症风险，以及有关全氟化合物暴露和健康的其他研究。