Study of DDT and loss of clinically-recognized pregnancies in South Africa

南非 DDT 与临床认可妊娠流产的研究

• 批准号: 8149124
• 负责人: Matthew Longnecker
• 金额: $ 2.97万
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8149124
• 关键词: Pregnancy; South Africa

The field work has begun for this prospective study of early pregnancy loss (miscarriage and stillbirth) in relation to DDT exposure. A field team was hired and trained in early 2010, and enrollment began June 1. Subjects are being enrolled from 6 villages in Limpopo Province, South Africa, and DDT is currently in use for malaria control in 3 of them. As of August 31, 209 subjects have been evaluated for eligibility, and 181 were enrolled. About half of the enrolled subjects are from the villages sprayed with DDT. Of the 181, 8 were withdrawn, primarily because they had misrepresented their village of residence. Of the 172 subjects being followed, 3 have become pregnant. Thus, the field work is functioning well. Whether the present study design will yield adequate numbers of women who become pregnant while enrolled remains to be seen, as does whether the subjects enrolled have a suitably wide distribution of exposure to DDT.

这项关于与滴滴涕接触相关的早期妊娠损失（流产和死产）的前瞻性研究已经开始实地工作。 2010 年初聘请并培训了一个现场小组，并于 6 月 1 日开始招募。受试者来自南非林波波省的 6 个村庄，目前正在其中 3 个村庄使用滴滴涕控制疟疾。截至 8 月 31 日，已有 209 名受试者接受了资格评估，其中 181 名受试者入组。 大约一半的受试者来自喷洒滴滴涕的村庄。 在 181 人中，有 8 人被撤回，主要是因为他们谎报了自己的居住村。 在接受跟踪的 172 名受试者中，有 3 名已怀孕。 因此，现场工作进展顺利。 目前的研究设计是否会产生足够数量的在登记期间怀孕的妇女，以及登记的受试者是否具有适当广泛的滴滴涕暴露分布，还有待观察。