CSHL 2023 Conference on Telomeres & Telomerase

CSHL 2023端粒会议

• 批准号: 10671999
• 负责人: DAVID J. STEWART
• 金额: $ 3.1万
• 依托单位: COLD SPRING HARBOR LABORATORY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10671999
• 关键词: Acceleration; Age; Aging; Anemia; Area; Asian; Attention; Basic Science; Biochemical; Biogenesis; Biological Models; Biology; Biophysics; Birds; Bone marrow failure; Cancerous; Cell Aging; Cell Cycle Progression; Cell Death; Cell Maintenance; Cells; Cellular biology; Chromosomes; Clinical; Cognition Disorders; Complex; DNA; DNA Repair; DNA biosynthesis; Data; Dementia; Development; Disease; Dyskeratosis Congenita; Effectiveness; Ensure; Environment; Enzymes; Eukaryota; European; Faculty; Fertility; Fission Yeast; Fostering; Functional disorder; Future; Generations; Genetic Recombination; Genome Stability; Genomics; Health; Human; Individual; Industrialization; International; Laboratories; Length; Link; Liver Cirrhosis; Longevity; Maintenance; Malignant Neoplasms; Malignant neoplasm of lung; Meiosis; Molecular; Mus; Mutation; Nature; Nematoda; Nucleic Acids; Oral; Organism; Participant; Pathology; Pathway interactions; Patients; Plants; Play; Postdoctoral Fellow; Premature aging syndrome; Prevention; Process; Proteins; Protozoa; Publications; Pulmonary Fibrosis; RNA-Directed DNA Polymerase; Rana; Recording of previous events; Regulation; Research; Research Institute; Research Personnel; Role; Saccharomycetales; Scientist; Syndrome; System; Telomerase; Telomere Maintenance; Telomere Shortening; Time; Woman; Work; age related; broadening participation research; cancer risk; career; fly; genome integrity; graduate student; healthspan; innovation; insight; interest; laboratory facility; meetings; model organism; posters; protein complex; segregation; senescence; single molecule; stem cells; success; symposium; targeted treatment; telomere; tumorigenesis; unpublished works; virtual

Cold Spring Harbor Laboratory Conference on Telomeres and Telomerase May 2–6, 2023 Abstract Telomeres are specialized protein-nucleic acid complexes that protect the ends of eukaryotic chromosomes. In most eukaryotes, telomeres contain short DNA repeats that are maintained by the telomerase reverse transcriptase. It has long been recognized that age and replication-associated telomere shortening is a driver of the cellular and organismal aging process, and that telomere length and integrity are regulators of human life span. Short or dysfunctional telomeres drive cells into senescence or cell death and are causative for numerous age-associated pathologies in humans, ranging from stem cell dysfunction, cognitive disorders and dementia to the age dependent increase in cancer risk. Mutations in telomere and telomerase components causing accelerated telomere shortening, such as observed in Dyskeratosis Congenita are directly associate with age- associated disorders and reduced lifespan, emphasizing the importance of understanding telomere function for the human health span and prevention of age-associated pathologies. As a result, the telomere field is now highly diverse and dynamic, representing a wide variety of research areas in which telomeres play crucial roles (aging, telomere syndromes, stem cells, cell cycle progression, cancer, meiosis and fertility, recombination, replication). The field encompasses research with mouse and human systems as well as insights gained from a wide variety of different model organisms (birds, frogs, flies, plants, nematodes, protozoa, budding yeast, fission yeast). This meeting focuses on understanding the interplay of telomeric proteins with cellular pathways that regulate genome integrity, on progress in the fields of telomerase regulation and biogenesis, on the regulation of aging and immortality by telomere maintenance pathways and on telomere dependent pathologies as function of telomere length, integrity and organismal age. The previous twelve Cold Spring Harbor Laboratory meetings on Telomeres and Telomerase have been crucial in bringing together a diverse group of researchers from all parts of the world, and have resulted in vigorous discussion and synergistic interactions stimulated by the presentation of mostly unpublished data. Because the CSHL Telomeres and Telomerase conference remains the only opportunity for scientists in this rapidly growing field to interact as a whole, this meeting is unique and of the utmost importance for the future of the field. Moreover, the format of CSHL meetings, for which nearly all talks are chosen from submitted abstracts, maximizes the opportunity for new independent investigators, postdocs and graduate students to present their work in a highly visible venue. These meetings have all had a uniformly high attendance rate from an international group of researchers, and the podium and posters have consistently presented the major discoveries in the field well before publication.

冷泉港实验室端粒和端粒酶会议 2023 年 5 月 2 日至 6 日 抽象的 端粒是特殊的蛋白质-核酸复合物，可以保护端粒的末端 在大多数真核生物中，端粒含有短的 DNA 重复序列。 长期以来人们就认识到端粒酶逆转录酶的作用。 年龄和复制相关的端粒缩短是细胞和 生物衰老过程，端粒长度和完整性是人体的调节因子 寿命较短或功能失调的端粒会导致细胞衰老或死亡。 是导致人类许多与年龄相关的病理的原因，包括干细胞 功能障碍、认​​知障碍和痴呆与年龄依赖性癌症增加 端粒和端粒酶成分的突变导致端粒加速。 缩短，例如在先天性角化不良中观察到的缩短与年龄直接相关 相关疾病和寿命缩短，强调了解的重要性 端粒对人类健康寿命和预防与年龄相关的功能 因此，端粒领域现在高度多样化和动态， 代表了端粒发挥关键作用的各种研究领域（衰老、 端粒综合征、干细胞、细胞周期进展、癌症、减数分裂和生育能力， 该领域包括小鼠和人类的研究。 系统以及从各种不同的模式生物（鸟类、 青蛙、苍蝇、植物、线虫、原生动物、芽殖酵母、裂殖酵母）。 专注于了解端粒蛋白与细胞途径的相互作用 调节基因组完整性，端粒酶调节领域的进展和 生物发生，通过端粒维持途径调节衰老和永生 以及作为端粒长度、完整性和端粒功能的端粒依赖性病理学 生物学年龄。 之前的十二次冷泉港实验室关于端粒和 端粒酶对于将来自各个领域的不同研究人员聚集在一起至关重要 世界部分地区，并引发了热烈的讨论和协同互动 受到大部分未发表数据的刺激，因为 CSHL 端粒。 端粒酶会议仍然是科学家们在这个快速发展的领域的唯一机会 作为一个整体互动不断发展的领域，这次会议是独特且至关重要的 此外，CSHL 会议的形式几乎都是针对该领域的讨论。 从提交的摘要中选择，最大限度地增加新独立的机会 研究人员、博士后和研究生以高度可见的方式展示他们的工作 这些会议的国际出席率都很高。 一组研究人员，讲台和海报一致地呈现了主要研究成果 早在出版之前就已经在该领域取得了发现。