CSHL 2023 Eukaryotic DNA Replication and Genome Maintenance Conference

CSHL 2023真核DNA复制与基因组维护会议

• 批准号: 10677192
• 负责人: DAVID J. STEWART
• 金额: $ 1.66万
• 依托单位: COLD SPRING HARBOR LABORATORY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-12 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10677192
• 关键词: Acceleration; American; Animals; Architecture; Archives; Area; Asian; Award; Bacteria; Biochemistry; Biology; Cell Cycle; Cell Cycle Progression; Cell Nucleus; Cells; Chromatin; Chromatin Structure; Chromosomes; Collaborations; Communication; Complement; Coupled; DNA replication fork; Data; Development; Disease; Disease Progression; Drosophila genus; Drug resistance; Ensure; Environment; Epigenetic Process; Eukaryota; European; Event; Evolution; Faculty; Feedback; Fostering; Gene Amplification; Generations; Genetic; Genetic Materials; Genome; Genome Stability; Genomic Instability; Genomics; Goals; Growth; Industrialization; International; Internet; Investigation; Laboratories; Lead; Learning; Length of Stay; Life; Maintenance; Malignant Neoplasms; Mammalian Cell; Minority; Mitotic Cell Cycle; Molecular; Molecular Biology; Nuclear; Oral; Organism; Participant; Peer Review; Peptide Initiation Factors; Play; Postdoctoral Fellow; Process; Productivity; Proteins; Published Comment; Radiation therapy; Regulation; Replication Initiation; Replication Origin; Replication-Associated Process; Research; Research Institute; Research Personnel; Role; S phase; Schedule; Science; Scientist; Selection Criteria; Series; Signal Transduction; Structure; System; Time; Vascular Plant; Woman; Work; Xenopus; Yeasts; anticancer research; biological adaptation to stress; biological research; biophysical techniques; cancer cell; career; chemotherapy; chromosome replication; event cycle; experience; fundamental research; genome integrity; graduate student; improved; interest; lectures; meetings; posters; rapid growth; repaired; replication stress; response; success; symposium; tumor; unpublished works

2023 CSHL CONFERENCE ON EUKARYOTIC DNA REPLICATION & GENOME MAINTENANCE PROJECT SUMMARY/ABSTRACT This conference will be the 19th biennial meeting on Eukaryotic DNA Replication and Genome Maintenance and follows the highly successful meetings that have been held at Cold Spring Harbor every other year since September 1987. It is the only regularly occurring meeting that is exclusively focused on eukaryotic DNA replication. Because of this focus, the meeting has played a major role in the rapid growth in our understanding of the eukaryotic DNA replication process and how it is integrated into the cell division cycle. This year’s conference will be devoted to fundamental research topics related to chromosome duplication, structure and function, and will include important areas of biological research in the areas of cell cycle and growth control, genomic amplification, and the response of the replication apparatus to DNA damage. As the field has moved forward over the past decade, we have placed an increased emphasis on the central role of DNA replication in the DNA damage and replication stress response, and strategies used by cells to minimize threats to genomic integrity arising from DNA replication. The rapid convergence of the DNA replication and DNA damage response fields makes this a timely meeting. The format of the meeting will ensure that recent results are communicated and discussed face-to-face, which will enhance progress and collaboration. The participation of young investigators, minority, and women scientists is strongly encouraged. The 2023 meeting will include a diverse array of topics, systems, and approaches including studies of chromosomal replication and gene amplification in organisms as diverse as bacteria, yeast, Drosophila, Xenopus and mammalian cells. Sessions will cover (1) Replication Origin Control in the Cell Cycle; (2) Developmental Control of DNA Replication and Replication Timing; (3) Chromatin and Genome/Nuclear Architecture; (4) Replication Fork Stalling, Stabilization and Checkpoint Activation; (5) Replication Initiation Factors and Origin Activation; (6) Replication-Coupled Genome Instability, Cancer and Disease (7) Causes and Consequences of Replication Stress; (8) Fork Progression and Termination. Uncontrolled DNA replication is a hallmark of tumors and errors in DNA replication lead to genomic instability, while the process of chromosome replication is a major target for chemo- and radiotherapy. The relevance of this meeting to cancer research, and ultimately to improved therapies, cannot be overemphasized. Replication of DNA is a fundamental process in all (eukaryotic) life. This meeting will focus on understanding the mechanism by which this process occurs, and how DNA replication contributes to genome stability, maintenance of the epigenetic state of a cell and how misregulation of this process contributes to diseases, most notably, cancer. The intellectual merits of this conference include the opportunity for leading investigators at all stages of their scientific careers to share and discuss their latest results and concepts. The informal peer review in oral and poster sessions is invaluable in providing rapid feedback that will fruitfully steer and accelerate future research. This conference also provides ample opportunity for learning and for building collaborations. We do not plan parallel sessions within the schedule so that all attendees share a common experience, while the secluded venue maximizes the likelihood of productive scientific exchange. Large, established conferences generally can have significant impact, and this Cold Spring meeting has undoubtedly driven forward research in DNA replication. Unique aspects of this conference that have particularly broad impact are the active participation of younger scientists who will particularly benefit from the opportunity to present their latest ideas. The conference archive (Leading strand video archive accessible by the internet) allows participants to share aspects of the conference with their colleagues who were unable to attend while protecting the right of the presenting authors to present unpublished research.

2023年CSHL真核DNA复制与基因组维护会议 项目概要/摘要 本次会议将是第19届真核DNA复制和基因组双年度会议 维护并遵循每隔一段时间在冷泉港举行的非常成功的会议 自 1987 年 9 月以来每年举办一次。这是唯一定期举行的专门关注真核生物的会议 由于这种关注，这次会议对我们的快速增长发挥了重要作用。 了解真核 DNA 复制过程以及它如何整合到细胞分裂周期中。 今年的会议将致力于与染色体复制、结构相关的基础研究主题 和功能，并将包括细胞周期和生长控制领域的重要生物学研究领域， 随着领域的发展，基因组扩增以及复制装置对 DNA 损伤的反应。 在过去的十年中，我们越来越重视 DNA 复制的核心作用 DNA 损伤和复制应激反应，以及细胞用来最小化对基因组威胁的策略 DNA 复制产生的完整性。DNA 复制和 DNA 损伤反应的快速收敛。 字段使这次会议变得及时，会议的形式将确保最新的结果得到传达。 并进行面对面讨论，这将促进进步和协作。 强烈鼓励研究人员、少数族裔和女科学家。 2023 年会议将包括各种主题、系统和方法，包括对 细菌、酵母、果蝇、非洲爪蟾等多种生物体中的染色体复制和基因扩增 会议将涵盖（1）细胞周期中的复制起点控制；（2）发育。 DNA 复制和复制时间的控制；(3) 染色质和基因组/核结构；(4) 复制叉停滞、稳定和检查点激活；（5）复制起始因素和起源； 激活；(6) 复制偶联的基因组不稳定性、癌症和疾病 (7) 的原因和后果 复制压力；（8）分叉进展和终止是肿瘤的标志。 DNA复制的错误会导致基因组不稳定，而染色体复制过程是一个主要因素。 本次会议与癌症研究的相关性，并最终改善。 疗法，怎么强调都不为过。 DNA 复制是所有（真核）生命的基本过程。本次会议将重点讨论。 了解这一过程发生的机制，以及 DNA 复制如何对基因组做出贡献 稳定性、细胞表观遗传状态的维持以及该过程的错误调节如何导致 这次会议的智力优势包括领导的机会。 处于科学职业生涯各个阶段的研究人员分享和讨论他们的最新成果和概念。 口头和海报会议中的非正式同行评审对于提供快速反馈非常宝贵，从而有效指导 并加速未来的研究，这次会议还提供了学习和建设的样本机会。 我们不会在日程安排内安排平行会议，以便所有与会者共享共同的内容。 经验，而僻静的场所最大限度地提高了富有成效的科学交流的可能性。 大型的、既定的会议通常会产生重大影响，而这次冷泉会议 毫无疑问，这次会议的独特之处推动了 DNA 复制研究的发展。 年轻科学家的积极参与产生了广泛的影响，他们将特别受益于这个机会 展示他们的最新想法。会议档案（可通过互联网访问的领先视频档案） 允许与会者与无法参加会议的同事分享会议的各个方面 保护提交作者提交未发表研究的权利。