Bio-Informatics Research Network Coordinating Center (BIRN-CC)

生物信息学研究网络协调中心（BIRN-CC）

• 批准号: 7929936
• 负责人: Carl Kesselman
• 金额: $ 64.27万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-15 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7929936
• 关键词: Bio; Informatics; Research; Network; Coordinating

DESCRIPTION (provided by applicant): To respond to the needs for advanced infrastructure for collaborative biomedicine, the NCRR Biomedical Informatics Research Network (BIRN) was established to develop a federated and distributed infrastructure for the storage, retrieval, analysis, and documentation of biomedical imaging data. The network of BIRN participants initially involved three testbeds with a neuroscience emphasis. The BIRN Coordinating Center (BIRN CC) is an important piece in the overall BIRN network, serving to develop, implement, and support the information technology infrastructure necessary to achieve distributed collaborations and data sharing between BIRN users. The current BIRN CC consists of a partnership between computer scientists, neuroscientists, and engineers based at the San Diego Super Computing Center (SDSC). In this proposal, we address issues that have hindered collaborative research effort. We will evolve BIRN with new capabilities, using proven techniques that are already being utilized in other disciplines to automate the data publication process and to form "virtual data warehouses" that provides unified query interfaces over disparate and distributed data sources Specifically: 1) we will transition the BIRN CC to a new site (ISI at USC); 2) migrate the core infrastructure to a virtual machine based deployment strategy; 3) leverage cyberinfrastructure tools to provide stability, scalability and interoperability; 4) replace Storage Resource Broker-based data solution with a service-based federated data management infrastructure, 4) move the BIRN Data Repository to storage hosted at ISI/USC, 5) migrate and support the most mature and extensible tools currently used by BIRN user base new services framework; 6) create an infrastructure allowing other developers to integrate tools into BIRN, 7) implement pragmatic data curation procedures focusing on creating a framework for using multiple ontologies. Finally, we propose a new. governance structure that will be more responsive to the needs of the growing BIRN community. This new model will allow expansion of the BIRN user base and domains and will position BIRN at the forefront of new efforts to store primary data linked to peer-reviewed publication, taking advantage of new NIH open-access policies. Public Health Relevance: Biomedical research benefits greatly from the integration of biomedical imaging, clinical, and behavioral data from multiple independent institutions. This project will provide a data sharing infrastructure that will enable researchers to investigate complex data-driven problems, otherwise impossible. The impact will be dramatic as multi-model data analysis has become fundamental to the development of evidence-based medicine.

描述（由申请人提供）：为了满足协作生物医学的高级基础架构的需求，建立了NCRR生物医学信息学研究网络（BIRN），以开发用于存储，检索，分析和文档生物医学成像数据的联合和分布式基础架构。 BIRN参与者的网络最初涉及三个具有神经科学重点的测试床。 BIRN协调中心（BIRN CC）是BIRN网络中的重要组成部分，它为实现BIRN用户之间的分布式协作和数据共享所需的信息技术基础架构提供了开发，实施和支持。当前的BIRN CC包括位于圣地亚哥超级计算中心（SDSC）的计算机科学家，神经科学家和工程师之间的合作伙伴关系。在此提案中，我们解决了阻碍协作研究工作的问题。我们将使用已经在其他学科中使用的验证技术来发展BIRN，以自动化数据出版过程并形成“虚拟数据仓库”，这些仓库为统一的查询接口而不是分散的和分布式数据源，并且我们将把Birn CC转移到新的站点（ISI ATC ATC）； 2）将核心基础架构迁移到基于虚拟机的部署策略； 3）利用网络基础设施工具提供稳定性，可扩展性和互操作性； 4）用基于服务的联合数据管理基础架构替换存储资源经纪的数据解决方案，4）将BIRN数据存储库移至ISI/USC托管的存储，5）迁移并支持Birn用户基础新服务框架当前使用的最成熟和可扩展工具； 6）创建一个基础架构，允许其他开发人员将工具集成到BIRN中，7）实现务实的数据策划程序，重点是创建用于使用多个本体论的框架。最后，我们提出了一个新。治理结构将对不断增长的Birn社区的需求更敏感。这种新模型将允许扩展BIRN用户群和域，并利用新的NIH Open-Access策略，将Birn放在新的努力中，将BIRN放在新的努力中。 公共卫生相关性：生物医学研究受益于多个独立机构的生物医学成像，临床和行为数据的整合。该项目将提供数据共享基础架构，该基础架构将使研究人员能够研究复杂的数据驱动问题，否则就不可能。由于多模型数据分析已成为循证医学的发展，因此影响将是戏剧性的。