The USC (Re)Building the Kidney Coordinating Center

南加州大学（重建）肾脏协调中心

• 批准号: 9146890
• 负责人: Carl Kesselman
• 金额: $ 125.29万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-23 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9146890
• 关键词: Acute; Address; Award; Biological Models; Birth; Blood Vessels; Cell physiology; Chronic; Collaborations; Collection; Communication; Communication Tools; Communities; Complement; Complex; Coordination and Collaboration; Data; Data Coordinating Center; Development; Diagnosis; Dialysis procedure; Education and Outreach; Elements; Ensure; Epithelial; FaceBase; Feedback; Feeds; Genomics; Goals; Health; Image; Individual; Injury; Institutes; International; Internet; Interview; Kidney; Kidney Diseases; Kidney Transplantation; Knowledge; Leadership; Life; Methods; Molecular; Monitor; National Institute of Diabetes and Digestive and Kidney Diseases; Nephrons; Organ; Patients; Pattern; Play; Policies; Population; Procedures; Process; Publications; Publishing; Renal function; Renal tubule structure; Research; Research Infrastructure; Research Personnel; Research Project Grants; Secure; Security; Staging; Structure; Suggestion; Surveys; Survival Rate; Teleconferences; Time; Transplantation; Work; data access; data portal; data sharing; design; empowered; experience; fetal; forging; human data; innovation; kidney repair; meetings; member; nephrogenesis; novel strategies; operation; organizational structure; progenitor; programs; repaired; restoration; stem; tool; user centered design; web site; working group

 DESCRIPTION (provided by applicant): The functional unit of the mammalian kidney is the nephron - a complex, composite structure comprising an epithelial renal tubule with a closely associated specialized vascular network. Nephrons arise from a nephrogenic stem/progenitor population that only exists during fetal life. Consequently, the entire complement of nephrons is formed prior to birth. Thereafter, restoration of existing nephron structures is the organ's intrinic strategy for kidney repair following acute, and likely chronic, injury episodes. From studies in non-human model systems, we have a general framework for the molecular and cellular processes at play during kidney development and an understanding is emerging of intrinsic repair processes that maintain normal kidney function. Unfortunately, normal repair processes are inadequate: 1,000,000 patients are currently diagnosed with end state renal disease (ESRD), approximately 400,000 of these are on dialysis with a mean 5-year survival rates of 38%. The only option beyond dialysis for the ESRD patient is kidney transplant, but the number of transplants - approximately 20,000/year - does not match patient need. The long-term goal of the (Re)Building the Kidney Consortium is to harness our knowledge of nephron development and repair to forge innovative new approaches to treat injury and disease of the kidney. The consortium is being developed with the underlying thesis that a coordinated, focused, adaptive and interactive program of research by several groups has the potential to yield results in a timeframe that would not be possible through a static collection of independent single investigator sponsored research projects. Coordination across the research consortium demands the ability to rapidly integrate new research projects, communicate results, and share knowledge and data across the consortium. It is not enough to publish results at the end of a study, but rather, it must be possible to incrementally share at all stages of the research process. To address these issues, we propose to create a ReBuilding the Kidney Coordinating Center (RBKC) to ensure the consortium operates effectively as a coordinated research network, maximizing the value of individual projects, and communicates consortium activities to the broad research community. Specifically, the RBKC aims to: 1) create organizational structure and processes that will enable seamless and frequent communication and collaboration between RBKC researchers, the NIDDK and the broader research community, 2) create a data portal that will empower changing collections of researchers to rapidly create, analyze, share and discover diverse types of data, 3) broaden the research community and create a framework for targeted shorter term research results by establishing and managing an opportunity pool program, 4) disseminate consortium results to the broader research community. In total, the impact of these elements of the RBKC will accelerate the rate of discovery within the consortium and by the broader community.

 描述（由适用提供）：哺乳动物肾脏的功能单元是肾单位 - 一种复杂的复合结构，完成具有密切相关的专业血管网络的上皮肾管。肾脏是由仅在胎儿生命中存在的肾病茎/祖细胞群引起的。因此，肾单位的整个完成是在出生前形成的。此后，恢复现有的肾单位结构是急性后肾脏修复的内在策略，可能是慢性损伤发作。从非人类模型系统中的研究中，我们有一个通用框架，用于肾脏发育过程中发挥作用的分子和细胞过程，并且有一种理解是对维持正常肾脏功能的内在修复过程的出现。不幸的是，正常的维修过程不足：目前有1,000,000名患者被诊断出患有终端肾脏疾病（ESRD），其中约有400,000名患有透析，平均5年生存率为38％。 ESRD患者透析以外的唯一选择是肾脏移植，但移植的数量（约20,000/年）与患者的需求不符。建立肾脏财团的长期目标是利用我们对肾脏发展和修复的了解，以创造创新的新方法来治疗肾脏的损伤和疾病。该财团是通过基本论点开发的，即几个小组的协调，集中，适应性和互动研究计划的潜力在时间范围内产生结果，而这种时间范围是通过静态的独立单一研究者赞助的研究项目而无法静态收集的。整个研究财团的协调要求能够快速整合新的研究项目，传达结果并在整个财团中共享知识和数据。在研究结束时发布结果还不够，但是，必须在研究过程的所有阶段逐步共享。为了解决这些问题，我们建议创建一个重建肾脏协调中心（RBKC），以确保有效地作为协调的研究网络的财团运营，从而最大程度地提高单个项目的价值，并向广泛的研究社区传达联盟活动。具体而言，RBKC的目的是：1）创建组织结构和流程，将使RBKC研究人员，NIDDK和更广泛的研究社区之间无缝，频繁的沟通和协作，2）创建一个数据门户，该数据门户将赋予不断变化的研究人员的收集能力，从而快速地创建，分析和分析研究社区，以扩大研究范围，以扩大研究的范围，3）范围的范围，3）范围越来越范围，3）计划，4）将财团结果传播给更广泛的研究社区。总的来说，RBKC的这些要素的影响将加速隐私和更广泛的社区内的发现率。