USC GUDMAP Coordinating Center

南加州大学 GUDMAP 协调中心

• 批准号: 9548075
• 负责人: Carl Kesselman
• 金额: $ 30万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-15 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9548075
• 关键词: Address; Affect; American; Anatomy; Atlases; Big Data; Chronic Disease; Collaborations; Collection; Communication; Communication Tools; Communities; Congenital Abnormality; Consensus; Coordination and Collaboration; Data; Data Set; Databases; Defect; Development; Diabetes Mellitus; Digestive System Disorders; Disease; Education and Outreach; Elements; Ensure; Evaluation; Event; FaceBase; Feedback; Genitourinary system; Goals; Gonadal structure; Image Analysis; Imagery; Individual; Informatics; Institutes; Intuition; Kidney; Kidney Diseases; Knowledge; Life; Link; Lower urinary tract; Meta-Analysis; Methods; Modeling; Molecular; Mus; Nephrons; Ontology; Organoids; Pattern; Positioning Attribute; Process; Public Health; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Risk; Secure; Services; Teleconferences; Therapeutic; United States National Institutes of Health; Urinary tract; Validation; Vocabulary; Work; base; congenital anomaly; data integration; data portal; data sharing; data visualization; experience; human data; innovation; meetings; member; novel strategies; operation; organizational structure; outreach; programs; repository; therapeutic target; tool; user centered design; web site; working group

Project Summary Congenital anomalies of the kidney and urinary tract are common birth defects. These defects are a significant public health problem affecting Americans and further, may go undetected but increase the risk of chronic diseases later in life. Since its inception, the GenitoUrinary Development Molecular Anatomy Project (GUDMAP) has provided a framework and repository for extensive expression data to provide a molecular anatomy of genitourinary development in the mouse with the long-term goal to harness and share our knowledge of urogenital development to forge innovative new approaches to treat disease. This work has advanced our understanding of subpopulations and patterning events in the developing nephron, lower urinary tract, and gonads. A deep understanding of the molecular drivers of kidney formation serves to inform current efforts in the field to create kidney organoids for therapeutic and disease studies. We propose to operate a GUDMAP Database that will facilitate a coordinated, focused, adaptive and interactive program of research by several groups, yielding results faster than a static collection of independent research projects. Coordination across the research consortium demands the ability to rapidly integrate new research projects, communicate results, and share knowledge and data across the consortium. Our work will generate connections between mouse and human data to link function to disease and thus identify potential causal and therapeutic targets. By providing tools to coalesce and link disparate datasets, we will provide efficient and easy methods to pose questions and further research. The GUDMAP Database will conduct meta- analysis to produce both informative ways to use the tools we build, and propose new testable hypotheses regarding urogenital development and disease. Our proposed GenitoUrinary Development Molecular Anatomy Project (GUDMAP) Database that will: 1) create organizational structure and processes that will enable seamless and frequent communication and collaboration between GUDMAP researchers, the National Institute for Diabetes and Digestive and Kidney Diseases (NIDDK) and the broader research community; 2) create a highly usable database that will empower changing collections of researchers to rapidly upload, organize, and search heterogeneous data types; 3) build a comprehensive toolkit for data annotation, curation, analysis, visualization, and cross validation; 4) broaden the research community and create a framework for targeted shorter term research results by establishing an opportunity pool program; 5) disseminate consortium resources to the wider research community. In total, the impact of these elements of the GUDMAP will accelerate the rate of discovery within the consortium and the broader community.

项目摘要 肾脏和尿路的先天异常是常见的先天缺陷。这些缺陷是重要的 影响美国人的公共卫生问题可能未被发现，但会增加长期的风险 以后的疾病。自成立以来，泌尿生殖发展分子解剖项目 （gudmap）为广泛的表达数据提供了一个框架和存储库，以提供分子 小鼠泌尿生殖器发展的解剖学，其长期目标是利用和分享我们的 泌尿生殖器发育的知识，以创新治疗疾病的新方法。这项工作有 提高了我们对发育中的肾单位中亚群和图案事件的理解，尿液较低 区域和性腺。对肾脏形成的分子驱动因素有深刻的理解，可以告知电流 该领域的努力为治疗和疾病研究创建肾脏器官。 我们建议操作一个GUDMAP数据库，该数据库将有助于协调，专注，适应性和 与静态的独立集合相比，多个小组的研究互动计划更快 研究项目。整个研究联盟之间的协调需要快速整合新的能力 研究项目，传达结果并在整个财团中共享知识和数据。我们的工作将 在小鼠和人类数据之间产生连接以将功能与疾病联系起来，从而确定潜力 因果和治疗靶标。通过提供合并和链接不同数据集的工具，我们将提供 提出问题并进一步研究的高效和简单方法。 GUDMAP数据库将进行元数据 分析以产生使用我们构建的工具并提出新的可测试假设的两种有益的方法 关于泌尿生殖的发育和疾病。 我们提出的泌尿生殖发展分子解剖项目（GUDMAP）数据库，该项目将：1）创建 组织结构和流程将实现无缝和频繁的沟通以及 Gudmap研究人员，国家糖尿病和消化研究所与肾脏之间的合作 疾病（NIDDK）和更广泛的研究社区； 2）创建一个高度可用的数据库，该数据库将授权 更改研究人员的收集以快速上传，组织和搜索异质数据类型； 3）构建 用于数据注释，策展，分析，可视化和交叉验证的综合工具包； 4）扩展 研究界并通过建立一个针对目标较短的学期研究结果创建一个框架 机会池计划； 5）将财团资源传播给更广泛的研究社区。总共 这些因素对GudMap的影响将加速财团内的发现率 更广泛的社区。