FaceBase 2 Coordinating Center

FaceBase 2 协调中心

• 批准号: 8849891
• 负责人: Carl Kesselman
• 金额: $ 197.33万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-16 至 2019-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8849891
• 关键词: Advisory Committees; Animal Model; Architecture; Bioinformatics; Biological; Collaborations; Collection; Communication; Communities; Data; Data Analyses; Data Element; Data Linkages; Data Set; Databases; Development; Dysmorphology; Ensure; FaceBase; Feedback; Fostering; Funding; Gene Expression; Genetic; Genomics; Goals; Health; Human; Image; Imagery; Knowledge; Lead; Leadership; Link; Methods; Mus; Participant; Play; Policies; Process; Proteomics; Regulatory Pathway; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Role; Secure; Security; Services; Site; Staging; Structure; Teleconferences; Work; Yang; base; craniofacial; craniofacial development; data integration; data management; data sharing; data visualization; design; experience; human data; imaging modality; instrumentation; meetings; member; migration; operation; tool; user centered design

DESCRIPTION (provided by applicant): The FaceBase consortium is a distributed network of researchers investigating craniofacial development and dysmorphology. The consortium includes research projects directly participating via funded "spoke" projects as well as members of the craniofacial research community at large. The collection, sharing and integration of heterogeneous data, including genetic, imaging, and anatomical, from human and animal models are essential for advancing craniofacial research. We will develop and maintain a FaceBase 2 Data Management and Integration Hub infrastructure that will properly store, represent, and serve these data to the research community, and in addition provide access to tools for visualizing, integrating, annotating, linking and analyzing the data. Our three broad aims will provide not only the needed data migration and management, but also a set of user-centered tools for data visualization, comparison and annotation. These are: Aim 1: Create an infrastructure driven by principles of ease of use and user centered design to manage data throughout its lifecycle. By taking a user centric approach and supporting the use of data throughout its lifecycle, the rate of discovery and utility of the hub can be maximized. Aim 2: Provide tools within the Hub that accelerate craniofacial research by enabling data annotation, integration and analysis. To maximize the utility of the Hub for both spoke projects and outside users, our proposed infrastructure will allow any user to define a personal workspace, organize datasets visualization tools and analysis tools into specific user-driven workflows. Aim 3: Promote use and collaboration across the FaceBase research network. The Hub will provide a wide range of collaboration tools and services to the consortium as well as organizing face-to-face meetings in order to enhance collaboration. We have assembled an experienced team of experts in bioinformatics, imaging, genetics, mouse and human studies, including FaceBase participants who bring firsthand knowledge of the needs within the craniofacial research community. The FaceBase team is intentionally diverse, to provide each spoke group at least one informed contact who will play an integral role in the development and implementation of the Hub, thereby ensuring that the data of each spoke project will have maximum impact on the community of researchers.

描述（由申请人提供）：FaceBase联盟是研究颅面发育和畸形学的研究人员的分布式网络。该财团包括通过资助的“讲话”项目以及整个颅面研究社区的成员直接参与的研究项目。来自人类和动物模型的异质数据的收集，共享和整合，包括遗传，成像和解剖学，对于推进颅面研究至关重要。我们将开发和维护Facebase 2数据管理和集成中心基础架构，该基础架构将正确存储，代表和将这些数据提供给研究社区，此外，还提供了对可视化，集成，注释，链接，链接和分析数据的工具的访问权限。我们的三个广泛目标不仅将提供所需的数据迁移和管理，还将提供一组以用户为中心的工具，用于数据可视化，比较和注释。这些是：目标1：创建一个基础架构，该基础架构由易用性和以用户为中心的设计原则驱动，以管理整个生命周期的数据。通过采用以用户为中心的方法并支持数据在整个生命周期中的使用，可以最大程度地提高集线器的发现和实用性速度。目标2：通过启用数据注释，集成和分析来加速颅面研究的枢纽中的工具。为了最大程度地利用式辐条项目和外部用户的枢纽的实用性，我们提出的基础架构将允许任何用户定义个人工作空间，组织数据集可视化工具和分析工具和分析工具中的特定用户驱动的工作流。目标3：促进整个面孔研究网络的使用和协作。该枢纽将为财团提供广泛的协作工具和服务，并组织面对面的会议，以增强协作。我们组建了一支经验丰富的生物信息学专家团队，成像，遗传学，鼠标和人类研究，包括面对面的参与者，他们对颅面研究社区内的需求进行了第一手了解。 Facebase团队有意地多样化，为每个讲话小组提供至少一个知情的联系人，他们将在集线器的开发和实施中发挥不可或缺的作用，从而确保每个讲话项目的数据将对研究人员社区产生最大的影响。