Signature Research Project

签名研究项目

基本信息

批准号：
10577120
负责人：
Edwin D Boudreaux
金额：
$ 114.38万
依托单位：
UNIV OF MASSACHUSETTS MED SCH WORCESTER
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-04-05 至 2028-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10577120
关键词：
Acceleration Accident and Emergency department Address Adopted Adoption Adult Affect Age Ambulatory Care Award Behavioral Behavioral inhibition Black race Caring Cessation of life Clinical Colorado Consumption Counseling Data Distress Effectiveness Electronic Health Record Elements Emergency Care Emergency Department patient Emergency department visit Environment Ethnic Origin Evidence based intervention Evidence based practice Exercise Exploration, Preparation, Implementation, and Sustainment Exposure to Feeling suicidal Foundations Funding Future Grant Health Health Care Surveys Healthcare Systems Home Hospitalization Hybrids In Situ Individual Interruption Intervention Interview Investigation Investigational Therapies Knowledge Learning Module Libraries Life Mediating Mediation Methodology Methods Modeling Monitor National Institute of Mental Health Nature Ohio Outcome Output Patient Outcomes Assessments Patients Performance Persons Process Productivity Race Randomized Randomized, Controlled Trials Registries Research Design Research Domain Criteria Research Personnel Research Project Grants Resources Risk Assessment Safety Sampling Self-Injurious Behavior Series Site Small Business Innovation Research Grant Small Business Technology Transfer Research Social support Solid Standardization Subgroup Suicide Suicide prevention Surveys System Technology Telephone Time Translating Translations Visit Vital Statistics Wait Time active comparator acute care arm behavioral health care delivery clinical care comparative effectiveness study completed suicide coping cost design digital digital technology economic outcome efficacy study efficacy testing evidence base experience health care economics high risk high risk population implementation design implementation framework implementation outcomes implementation process implementation science implementation strategy improved indexing innovation medical schools novel patient engagement point of care prevent routine care scale up secondary outcome sex single-blind trial skills smartphone application success suicidal suicidal behavior suicidal individual suicidal morbidity suicidal risk suicide rate technology development treatment as usual trial comparing usability wasting

项目摘要

JASPR (SIGNATURE PROJECT): ABSTRACT Significance: The significance of this Signature Project is derived from its powerful combination of (1) targeting a high-risk population -- adult patients at risk for suicide presenting to emergency departments (EDs); (2) addressing trenchant barriers that have prevented delivery of suicide-related evidence-based practices (EBPs) in the ED through an innovative, multi-component, NIMH-funded technology called Jaspr; and (3) evaluating Jaspr’s efficacy, effectiveness, and implementation, all in the same highly efficient study. Investigators: Jaspr’s project team has pioneered ED systems-based suicide prevention using continuous quality improvement implementation strategies (Boudreaux, Kiefe, Larkin, Johnson, Volturo); digital behavioral health technology development and deployment (Boudreaux, Dimeff, Gerber); using multi-method approaches, including patient-reported measures, electronic health record (EHR) data, and death registries, for outcome and intervention target ascertainment (Boudreaux, Kiefe, Gerber); implementation science research design and analytic methodologies (Kiefe, Yang, Larkin); and healthcare economics (Singh, Clements). Innovation: This will be the first study to comprehensively evaluate a multi-component suicide prevention technology that facilitates delivery of suicided-related EBPs while replacing wasted waiting time with productive time. Its multi-component nature satisfies several key performance elements for systems adopting Zero Suicide. A novel, award-winning hybrid study design called Complementary Randomized Controlled Trial and Real-World Study for Efficacy, Effectiveness, and Implementation Design (CREID) will be used. Approach: CREID comprises two separate but related components or parts. Part A, Randomized Controlled Trial (RCT), will be a patient-level, randomized, parallel-arm, single-blind trial (n=670) comparing Jaspr (Intervention) to enhanced treatment as usual (ETAU; Active Comparator Control). Consistent with NIMH’s experimental therapeutics paradigm, Part A’s primary aim is to determine Jaspr’s efficacy in improving suicide- related outcomes in the 12 months after the index ED visit and to explore its potential mechanisms of action through engaging patient intervention targets and EBP delivery. In Part B, Real-World Study, four diverse EDs will implement Jaspr as part of routine care. Part B’s primary aim will be to evaluate Jaspr’s effectiveness when used in a real-world setting. Finally, both Parts will be used to explore Jaspr’s implementation, including establishing system, clinician, and patient factors anticipated to affect Jaspr adoption and implementation. Environment: The UMass Chan Medical School (UMass), Jaspr Health, and partnering organizations have proven their ability to support this ambitious study by their success with numerous NIMH-funded, systems-based suicide prevention studies and SBIR/STTRs technology grants, including the SBIR that created Jaspr. Impact: Accelerated translation of Jaspr and advancing knowledge pertaining to the implementation of suicide care technologies in the ED setting has the potential to help thousands of suicidal individuals annually.

JASPR（标志性项目）：摘要意义：这个标志性项目的意义源于它的强大组合：(1) 针对高危人群——有自杀风险的成年患者到急诊室就诊； (2) 解决阻碍自杀相关循证实践的严重障碍 (EBP) 在 ED 中通过一种由 NIMH 资助的创新技术 Jaspr 实现；以及 (3) 评估 Jaspr 的功效、有效性和实施情况，所有这些都在同一个高效的研究中进行。调查人员：Jaspr 的项目团队开创了基于 ED 系统的自杀预防方法，使用连续质量改进实施策略（Boudreaux、Kiefe、Larkin、Johnson、Volturo）；使用多种方法开发和部署卫生技术（Boudreaux、Dimeff、Gerber）；包括患者报告的措施、电子健康记录 (EHR) 数据和死亡登记，以了解结果和干预目标确定（Boudreaux、Kiefe、Gerber）；实施科学研究设计和分析方法（Kiefe、Yang、Larkin）；和医疗经济学（Singh、Clements）。创新：这将是第一项全面评估多因素自杀预防的研究该技术有助于提供与自杀相关的 EBP，同时以高效的方式取代浪费的等待时间其多组件性质满足采用零自杀系统的几个关键性能要素。一种新颖的、屡获殊荣的混合研究设计，称为补充随机对照试验和真实世界将使用功效、效果和实施设计研究 (CREID)。方法：CREID 由两个独立但相关的组成部分或部分组成，A 部分，随机控制。试验（RCT）将是一项患者水平、随机、平行、单盲试验（n=670），比较 Jaspr （干预）照常加强治疗（ETAU；主动比较控制）与 NIMH 一致。实验治疗范式，A 部分的主要目的是确定 Jaspr 在改善自杀方面的功效急诊科就诊后 12 个月内的相关结果，并探讨其潜在的作用机制通过参与患者干预目标和 EBP 实施，在 B 部分“真实世界研究”中，四个不同的急诊室。将实施 Jaspr 作为日常护理的一部分，B 部分的主要目的是评估 Jaspr 的有效性。最后，这两个部分都将用于探索 Jaspr 的实现，包括建立预计会影响 Jaspr 采用和实施的系统、临床医生和患者因素。环境：麻省大学陈医学院 (UMass)、Jaspr Health 和合作组织通过大量 NIMH 资助的、基于系统的研究的成功，证明了他们支持这项雄心勃勃的研究的能力自杀预防研究和 SBIR/STTR 技术拨款，包括创建 Jaspr 的 SBIR。影响：加速 Jaspr 的翻译并推进与实施相关的知识急诊室的自杀护理技术每年有可能帮助数千名自杀者。