Signature Research Project

签名研究项目

基本信息

批准号：
10577120
负责人：
Edwin D Boudreaux
金额：
$ 114.38万
依托单位：
UNIV OF MASSACHUSETTS MED SCH WORCESTER
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-04-05 至 2028-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10577120
关键词：
Acceleration Accident and Emergency department Address Adopted Adoption Adult Affect Age Ambulatory Care Award Behavioral Behavioral inhibition Black race Caring Cessation of life Clinical Colorado Consumption Counseling Data Distress Effectiveness Electronic Health Record Elements Emergency Care Emergency Department patient Emergency department visit Environment Ethnic Origin Evidence based intervention Evidence based practice Exercise Exploration, Preparation, Implementation, and Sustainment Exposure to Feeling suicidal Foundations Funding Future Grant Health Health Care Surveys Healthcare Systems Home Hospitalization Hybrids In Situ Individual Interruption Intervention Interview Investigation Investigational Therapies Knowledge Learning Module Libraries Life Mediating Mediation Methodology Methods Modeling Monitor National Institute of Mental Health Nature Ohio Outcome Output Patient Outcomes Assessments Patients Performance Persons Process Productivity Race Randomized Randomized, Controlled Trials Registries Research Design Research Domain Criteria Research Personnel Research Project Grants Resources Risk Assessment Safety Sampling Self-Injurious Behavior Series Site Small Business Innovation Research Grant Small Business Technology Transfer Research Social support Solid Standardization Subgroup Suicide Suicide prevention Surveys System Technology Telephone Time Translating Translations Visit Vital Statistics Wait Time active comparator acute care arm behavioral health care delivery clinical care comparative effectiveness study completed suicide coping cost design digital digital technology economic outcome efficacy study efficacy testing evidence base experience health care economics high risk high risk population implementation design implementation framework implementation outcomes implementation process implementation science implementation strategy improved indexing innovation medical schools novel patient engagement point of care prevent routine care scale up secondary outcome sex single-blind trial skills smartphone application success suicidal suicidal behavior suicidal individual suicidal morbidity suicidal risk suicide rate technology development treatment as usual trial comparing usability wasting

项目摘要

JASPR (SIGNATURE PROJECT): ABSTRACT Significance: The significance of this Signature Project is derived from its powerful combination of (1) targeting a high-risk population -- adult patients at risk for suicide presenting to emergency departments (EDs); (2) addressing trenchant barriers that have prevented delivery of suicide-related evidence-based practices (EBPs) in the ED through an innovative, multi-component, NIMH-funded technology called Jaspr; and (3) evaluating Jaspr’s efficacy, effectiveness, and implementation, all in the same highly efficient study. Investigators: Jaspr’s project team has pioneered ED systems-based suicide prevention using continuous quality improvement implementation strategies (Boudreaux, Kiefe, Larkin, Johnson, Volturo); digital behavioral health technology development and deployment (Boudreaux, Dimeff, Gerber); using multi-method approaches, including patient-reported measures, electronic health record (EHR) data, and death registries, for outcome and intervention target ascertainment (Boudreaux, Kiefe, Gerber); implementation science research design and analytic methodologies (Kiefe, Yang, Larkin); and healthcare economics (Singh, Clements). Innovation: This will be the first study to comprehensively evaluate a multi-component suicide prevention technology that facilitates delivery of suicided-related EBPs while replacing wasted waiting time with productive time. Its multi-component nature satisfies several key performance elements for systems adopting Zero Suicide. A novel, award-winning hybrid study design called Complementary Randomized Controlled Trial and Real-World Study for Efficacy, Effectiveness, and Implementation Design (CREID) will be used. Approach: CREID comprises two separate but related components or parts. Part A, Randomized Controlled Trial (RCT), will be a patient-level, randomized, parallel-arm, single-blind trial (n=670) comparing Jaspr (Intervention) to enhanced treatment as usual (ETAU; Active Comparator Control). Consistent with NIMH’s experimental therapeutics paradigm, Part A’s primary aim is to determine Jaspr’s efficacy in improving suicide- related outcomes in the 12 months after the index ED visit and to explore its potential mechanisms of action through engaging patient intervention targets and EBP delivery. In Part B, Real-World Study, four diverse EDs will implement Jaspr as part of routine care. Part B’s primary aim will be to evaluate Jaspr’s effectiveness when used in a real-world setting. Finally, both Parts will be used to explore Jaspr’s implementation, including establishing system, clinician, and patient factors anticipated to affect Jaspr adoption and implementation. Environment: The UMass Chan Medical School (UMass), Jaspr Health, and partnering organizations have proven their ability to support this ambitious study by their success with numerous NIMH-funded, systems-based suicide prevention studies and SBIR/STTRs technology grants, including the SBIR that created Jaspr. Impact: Accelerated translation of Jaspr and advancing knowledge pertaining to the implementation of suicide care technologies in the ED setting has the potential to help thousands of suicidal individuals annually.

JASPR（签名项目）：摘要意义：该签名项目的重要性来自其强大组合（1）针对高风险人口 - 有自杀风险的成年患者向急诊科（EDS）出现；（2）解决防止自杀相关的循证实践的危害障碍（EBP）通过一种创新的，多组件的NIMH资助的技术，称为JASPR；（3）在同一高效的研究中，评估JASPR的有效性，有效性和实施。调查人员：JASPR的项目团队使用连续的启用了基于系统的自杀性自杀质量改进实施策略（Boudreaux，Kiefe，Larkin，Johnson，Volturo）；数字行为卫生技术开发与部署（Boudreaux，Dimeff，Gerber）；使用多方法方法，包括患者报告的措施，电子健康记录（EHR）数据和死亡登记处，以进行结果和干预目标确定（Boudreaux，Kiefe，Gerber）；实施科学研究设计和分析方法（Kiefe，Yang，Larkin）；和医疗保健经济学（辛格，克莱门茨）。创新：这将是首次全面评估多组分自杀预防的研究促进与产品更换浪费的等待时间的技术，可以促进与自杀相关的EBP的交付时间。它的多组分性质满意度用于采用零自杀的系统的几个关键性能元素。一种新颖的，屡获殊荣的混合研究设计，称为补充随机对照试验和现实世界将使用疗效，有效性和实施设计（CREID）的研究。方法：CREID包括两个单独但相关的组件或零件。 A部分，随机控制试验（RCT）将是患者级，随机的，平行的，单盲试验（n = 670），比较JASPR （干预）像往常一样增强治疗（ETAU；主动比较器对照）。与NIMH的一致实验疗法范式，A部分的主要目的是确定JASPR在改善自杀方面的效率索引ED访问后的12个月内的相关结果并探索其潜在的行动机制通过参与患者干预目标和EBP输送。在B部分，现实世界研究中，四个潜水员eds 将实施JASPR作为常规护理的一部分。 B部分的主要目的是评估JASPR的有效性在现实环境中使用。最后，这两个部分都将用于探索JASPR的实现，包括建立系统，临床和患者因素预计会影响JASPR采用和实施。环境：UMass Chan医学院（UMass），JASPR健康和合作组织通过众多基于系统的NIMH资助自杀预防研究和SBIR/STTRS技术赠款，包括创建JASPR的SBIR。影响：JASPR的加速翻译和促进与实施有关的知识 ED环境中的自杀护理技术每年有可能帮助数千名自杀人。