Advanced Training in Community Based Research; training in Bio-informatics, Drug Resistance and Pathogenesis

社区研究高级培训；

• 批准号: 10377962
• 负责人: Shungu Munyati
• 金额: $ 31.19万
• 依托单位: BIOMEDICAL RESEARCH & TRAINING INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-22 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10377962
• 关键词: Achievement; Address; African; Bioinformatics; Biological; Caring; Child; Communities; Data; Data Science; Development; Discipline; Drug resistance; Ensure; Environment; Epidemic; Epidemiology; Ethics; Evaluation; Fees; Genomics; Goals; Grant; HIV; Health; Institution; International; Leadership; Medical; Mentors; Methods; Modeling; Molecular; Molecular Epidemiology; Outcome; Outcome Assessment; Output; Pathogenesis; Phylogenetic Analysis; Policies; Population; Positioning Attribute; Postdoctoral Fellow; Prevention; Publications; Research; Research Methodology; Research Project Grants; Research Training; Resources; Sampling; Social Sciences; Students; Supervision; Training; United States National Institutes of Health; Universities; Writing; Zimbabwe; base; career; community based research; community setting; design; doctoral student; improved; innovation; payment; peer; public health priorities; skills; student training; transmission process; virus genetics; young woman

ABSTRACT: Advanced training in Community Based HIV Research In Zimbabwe with one of the highest HIV burdens in the world, data and samples collected in community based research can contribute valuable information to improve prevention and care. Building new skills and capacity for molecular epidemiology and genomics focuses on the best use of these resources. Training in the interdisciplinary continuum of basic lab research skills, bioinformatics, modeling and data science for relevant, ethical research will address Zimbabwe's National and NIH/Fogarty goals. We propose a 3- pronged approach: To develop research skills: We will conduct short course training for students and post-graduates to develop the skills underpinning contemporary community based research, to design innovative studies integrating geolocation, epidemiologic and molecular research methods to interpret data on HIV transmission and prevention. We propose to introduce and promote the use of bioinformatics, to develop skills in phylogenetic, host and viral genetics that can be applied to address the ongoing epidemic. To promote research at doctoral level: We request support for 5 PhD students, from biologic, social science or medical disciplines. Students registered with universities in Zimbabwe will identify suitable projects and mentors to conduct HIV research relevant to Drug resistance, Genomics and Pathogenesis of HIV in community based studies. Support will include payment of fees and a modest stipend; academic supervision and mentoring from local and/or international experts will be compensated to ensure interdisciplinary scientific development and quality of postgraduate outcomes. To develop future research leadership. This can be achieved by supporting postdoctoral fellows to conduct research in a mentored environment to develop research management, mentoring and grant writing skills to sustain their research career. The position of “Postdoctoral Fellow” is uncommon in African academic circles. As a research institution, the BRTI will permit Postdoctoral fellows to focus on developing leadership skills, implementing and analyzing ongoing projects. Fellows will design and manage their own projects and research teams, interpret data, articulate and present findings to peers under the guidance of mentors and complete applications for a research grant during their tenure. This 3-pronged approach will effectively build advanced health research capacity filling critical gaps in current HIV research in Zimbabwe. The activities and training will be directed towards combining new scientific methods to address the public health priorities of key populations: children, adolescents and young women, in community settings. The evaluation strategies will include formative and summative evidence of activity and output. Outcome assessment will encompass through evaluations of student and fellow achievements, presentations and publications, and their impact on policy and stakeholders.

摘要：基于社区的艾滋病毒研究的高级培训 在津巴布韦，拥有世界上最高的艾滋病毒伯伦斯之一，在社区中收集的数据和样本 基于的研究可以为改善预防和护理提供宝贵的信息。建立新技能和 分子流行病学和基因组学的能力集中在这些资源的最佳使用上。培训 基本实验室研究技能，生物信息学，建模和数据科学的跨学科连续性 相关的道德研究将解决津巴布韦的国家和NIH/Fogarty目标。我们提出了3- 钢琴的方法： 为了培养研究技能：我们将为学生和研究生进行简短的课程培训 发展基于当代社区研究的技能，以设计创新研究 整合地理位置，流行病学和分子研究方法来解释有关HIV传播数据的数据 和预防。我们建议介绍和促进生物信息学的使用，以发展技能 系统发育，宿主和病毒遗传学，可用于解决持续的流行病。 促进博士学位的研究：我们要求从生物学，社会的5位学生提供支持 科学或医学学科。在津巴布韦大学注册的学生将确定合适的项目 和导师进行与耐药性，基因组学和HIV发病机理有关的HIV研究 基于社区的研究。支持将包括支付费用和适度的压力；学术监督 并将获得本地和/或国际专家的心理，以确保跨学科科学 研究生成果的发展和质量。 发展未来的研究领导力。这可以通过支持博士后研究员来实现 在指导环境中的研究，以发展研究管理，指导和授予写作技巧 维持他们的研究职业。在非洲学术界，“博士后研究员”的地位并不常见。 作为一家研究机构，BRTI将允许博士后研究员专注于发展领导技能， 实施和分析正在进行的项目。研究员将设计和管理自己的项目， 在导师和 在其任期期间完成研究补助金的申请。 这种三管齐下的方法将有效地建立先进的健康研究能力，以填补关键空白 津巴布韦目前的HIV研究。活动和培训将用于结合新 解决关键人群的公共卫生优先事项的科学方法：儿童，青少年和年轻人 妇女，在社区环境中。评估策略将包括形成性和总结性证据 活动和输出。结果评估将通过学生和研究员的评估涵盖 成就，演讲和出版物及其对政策和利益相关者的影响。