West Virginia Clinical and Translational Science Institute: A Statewide Organization Building Research Excellence and Engaging Communities to Improve Health

西弗吉尼亚州临床和转化科学研究所：全州范围内的组织，致力于打造卓越研究并吸引社区改善健康

• 批准号: 10876541
• 负责人: Sally Lynn Hodder
• 金额: $ 64.43万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-15 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10876541
• 关键词: Agreement; Area; Artificial Intelligence; Award; COVID-19; COVID-19 disparity; COVID-19 patient; Clinical Research; Clinical Sciences; Clinical Trials; Collaborations; Data; Data Analytics; Data Linkages; Data Set; Databases; Decision Making; Development; Educational workshop; Electronic Health Record; Ensure; Frequencies; Health; Health system; Infrastructure; Institution; Institutional Review Boards; Machine Learning; Medicaid; Medicare; Methods; Minority Groups; National Center for Advancing Translational Sciences; National Institute of General Medical Sciences; Observational Study; Outcome; Outcome Assessment; Patient-Focused Outcomes; Patients; Persons; Policies; Population; Productivity; Reporting; Research; Research Infrastructure; Research Personnel; Resolution; SARS-CoV-2 infection; Sample Size; Science; Site; Techniques; Transfer Agreement; Translational Research; Underrepresented Minority; Underrepresented Populations; Underserved Population; Universities; Update; West Virginia; Work; clinical care; cohort; community engagement; comorbidity; coronavirus disease; dashboard; data exchange; data resource; geographic disparity; improved; improved outcome; interest; meetings; mortality; novel; patient subsets; privacy preservation; prospective; rural area; spatial epidemiology; symposium; tool; translational research program

ABSTRACT In 2020, the National COVID Cohort Collaborative (N3C) was established by the National Center for Data to Health (CD2H) in partnership with the National Center for Advancing Translational Sciences (NCATS) as a centralized national electronic health record (EHR) data resource for the study of COVID-19 patient outcomes. Over the past 3 years, the West Virginia Clinical and Translational Science Institute (WVCTSI) has leveraged the N3C initiative as a collaborative force across WV. In addition, N3C has served as an impetus to form a collaborative network among Institutional Development Award for Clinical and Translational Research (IDeA- CTR) programs to drive meaningful scientific initiatives to improve outcomes among populations in IDeA states, particularly underrepresented minority and underserved populations. WVCTSI has effectively led 12 IDeA-CTRs in productive N3C collaborations through a variety of activities. For Year 4 of the IDeA-CTR N3C initiative, WVCTSI will continue to provide network-wide infrastructure to drive relevant science and productivity, organizing monthly “All Hands On Deck” meetings and ensuring IDeA-CTR sites complete productivity reporting on a quarterly basis. We will build analytic capacity in several ways: 1) incorporating into Year 4 analyses of external datasets (e.g., Medicare, Medicaid) using privacy-preserving record linkage (PPRL), 2) expanding use of machine learning (ML) and artificial intelligence (AI) in N3C projects, leveraging existing knowledgeable IDeA-CTR investigators in those areas, and 3) introducing use of spatial analyses to investigate geographic disparities in COVID-19 related outcomes. We will also actively engage investigators in high quality COVID-19 data projects relevant to populations in their respective states by providing support to investigators that includes reviewing and responding to help desk tickets, thereby expediting resolution of all IDeA-CTR-generated tickets. We will also coordinate and conduct relevant symposia and workshops related to novel analytic techniques, ML/AI, and spatial epidemiology. Finally, we will increase frequency of EHR data uploads from WVU to occur monthly.

抽象的 2020年，国家数据中心建立了国家共同队列合作（N3C） 健康（CD2H）与国家前进的转化科学中心（NCAT）合作 用于研究COVID-19患者结局的集中国家电子健康记录（EHR）数据资源。 在过去的三年中，西弗吉尼亚州的临床和转化科学学院（WVCTSI）已利用 N3C倡议是WV的合作力量。此外，N3C已成为形成的动力 临床和翻译研究机构发展奖（Idea- CTR）推动有意义的科学倡议以改善思想人群中结果的计划 国家，特别是代表性不足的少数民族和服务不足的人口。 WVCTSI有效地领导了12 通过各种活动，Idea-CTR在生产性N3C合作中进行。在IDEA-CTR N3C的第4年 倡议，WVCTSI将继续提供网络范围内的基础架构，以推动相关科学和 生产力，组织每月的“全手甲板”会议，并确保Idea-CTR网站完成 生产力按季度报告。我们将以几种方式建立分析能力：1）合并 使用隐私的记录链接，进入外部数据集（例如Medicare，Medicaid）的4年级分析 （PPRL），2）在N3C项目中扩大机器学习（ML）和人工智能（AI）的使用，利用 这些领域的现有知识渊博的思想-CTR研究人员，以及3）将空间分析的使用引入 研究COVID-19中相关结果中的地理分布。我们还将积极与调查人员联系 在高质量的Covid-19中，与各自州中人口有关的数据项目通过提供支持 对于调查人员，包括审查和回应帮助办公桌票，从而加快了解决方案 所有Idea-Cr-can-enerated门票。我们还将协调和进行相关的研讨会和与研讨会有关 到新颖的分析技术，ML/AI和空间流行病学。最后，我们将增加EHR的频率 数据上传到WVU每月发生。