West Virginia Clinical and Translational Science Institute: Improving Health through Partnerships and Transformative Research

西弗吉尼亚临床和转化科学研究所：通过合作伙伴关系和变革性研究改善健康

• 批准号: 10293104
• 负责人: Sally Lynn Hodder
• 金额: $ 189.54万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-15 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10293104
• 关键词: Academic Medical Centers; Address; Americas; Appalachian Region; Area; Award; Cardiovascular Diseases; Cardiovascular system; Categories; Chronic Disease; Chronic lung disease; Clinical; Clinical Research; Clinical Sciences; Collaborations; Communication; Communities; Computerized Medical Record; Development; Epidemic; Funding; Future; Goals; Health; Health Priorities; Hepatitis C; Hospital Administration; Human; Individual; Infrastructure; Institutes; Investments; Kentucky; Lead; Malignant Neoplasms; Medical; Mentors; Modeling; National Institute for Occupational Safety and Health; Outcome; Overdose; Patient Recruitments; Pharmaceutical Preparations; Pilot Projects; Play; Policies; Policy Maker; Positioning Attribute; Productivity; Provider; Publications; Research; Research Infrastructure; Research Personnel; Role; Rural; Rural Community; Rural Population; Science; Scientist; Services; Site; Syndrome; Training; Training Support; Translational Research; Trust; United States; United States Department of Veterans Affairs; Universities; West Virginia; Work; addiction; base; commercialization; data repository; health disparity; improved; innovation; interdisciplinary approach; mortality; new technology; next generation; practice-based research network; recruit; success; translational scientist; trend

Mortality rates in Appalachia have progressively increased over recent years, in contrast to decreasing mortality rates observed in the remainder of the US. West Virginia was ranked 47th overall among the 50 states in the 2015 America's Health Rankings. In addition, WV remains at, or near, the bottom for a number of chronic diseases including cancer and cardiovascular disease. These observations alone do not capture the entire continuum of health related challenges in the state or region, but clearly emphasize the need for continued focus on, and investment in, research that underpins real solutions. The West Virginia Clinical and Translational Science Institute (WVCTSI) was created in 2012 through the initial Clinical and Translational Research (CTR) award and has subsequently formed a well-connected, statewide research network, creating the infrastructure to address the substantial health disparities that exist in West Virginia. The overarching goal of the WVCTSI is to serve as a collaborative hub to lead statewide innovation in clinical and translational research, catalyzing and accelerating development of solutions to vexing health problems. Over the past four years, WVCTSI has been a transformative force, implementing investigator mentoring services, establishing pilot project funding, forming a practice-based research network of 68 sites (mostly rural), creating an integrated data repository of two million unique electronic medical records, developing a broad-based culture of research integrity, and working with our partners to establish trust and effective collaboration. WVCTSI is now well positioned to attain the goals of this renewal application that include: 1) building sustainable research infrastructure that substantively contributes to improving WV health outcomes by 2022, 2) recruiting the next generation of clinician scientists and translational researchers that excel in team science and are positioned for long-term success, and 3) actively engaging with multiple stakeholders that include communities, medical providers, and policy makers to drive research that improves health of West Virginians. Our partners include all academic medical centers within the state as well as the University of Kentucky, the Veterans Administration, and the National Institute for Occupational Safety and Health. Through its collective activities and powerful partnerships, the WVCTSI will play a critical role in reversing the trend of increasing mortality rates in West Virginia and serve as a model for developing effective research infrastructure that provides solutions to regional health issues.

近年来，阿巴拉契亚的死亡率逐渐增加，与降低死亡率相反 在美国的其余部分中观察到的费率。西弗吉尼亚州在50个州中排名第47位 2015年美国的健康排名。此外，WV仍处于或附近的底部，用于多个慢性 包括癌症和心血管疾病在内的疾病。仅这些观察结果并不能捕获整个观察 国家或地区的健康与健康相关挑战的连续性，但清楚地强调了继续重点的需求 在研究基础的研究和投资的研究中。西弗吉尼亚州的临床和翻译 科学研究所（WVCTSI）于2012年通过最初的临床和转化研究（CTR）创建 奖励并随后建立了一个完善的全州研究网络，创建了基础架构 解决西弗吉尼亚州存在的实质性健康差异。 WVCTSI的总体目标是 作为一个合作枢纽，领导全州范围内的临床和转化研究，催化和 加速解决烦恼健康问题的解决方案。在过去的四年中，WVCTSI一直是 变革力量，实施研究人员指导服务，建立试点项目资金，形成一个 基于实践的研究网络由68个站点（主要是农村），创建了200万个集成数据存储库 独特的电子医疗记录，发展基于广泛的研究完整性文化，并与我们的合作 建立信任和有效协作的合作伙伴。 WVCTSI现在有能力实现这一目标 包括：1）建立可持续研究基础设施的续签应用，这实质上有助于 在2022年之前改善WV健康结果，2）招募下一代临床医生和翻译 在团队科学方面表现并获得长期成功的研究人员，以及3）积极参与 包括社区，医疗提供者和政策制定者在内的多个利益相关者，以推动研究 改善西弗吉尼亚人的健康。我们的合作伙伴还包括该州的所有学术医疗中心 作为肯塔基大学，退伍军人管理局和国家职业安全研究所 和健康。 WVCTSI通过其集体活动和强大的伙伴关系，将在 扭转西弗吉尼亚州死亡率提高的趋势，并作为发展有效的模型 研究基础设施，为区域健康问题提供解决方案。