West Virginia Clinical and Translational Science Institute: Improving Health through Partnerships and Transformative Research

西弗吉尼亚临床和转化科学研究所：通过合作伙伴关系和变革性研究改善健康

• 批准号: 10435710
• 负责人: Sally Lynn Hodder
• 金额: $ 367.28万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10435710
• 关键词: 2019-nCoV; Appalachian Region; Area; Artificial Intelligence; Automobile Driving; Award; Back; Big Data; COVID-19; COVID-19 pandemic; COVID-19 patient; Center for Translational Science Activities; Cessation of life; Clinical; Clinical Research; Clinical Sciences; Collaborations; Color; Communication; Communication Research; Communities; Data; Data Set; Development; District Hospitals; Electronic Health Record; Ensure; Family; Foundations; Funding; Goals; Health; Hispanics; Individual; Infrastructure; Institutes; Leadership; Machine Learning; Manuscripts; Medical center; Minority; Minority Groups; National Institute of General Medical Sciences; Native Americans; Network Infrastructure; New England; North Dakota; Patient-Focused Outcomes; Pediatric Hospitals; Persons; Population; Productivity; Puerto Rico; Research; Research Personnel; Rural; Rural Population; SARS-CoV-2 infection; Science; Site; Stimulus; Structure; Techniques; Training and Education; Translational Research; Underserved Population; United States; United States National Institutes of Health; Universities; Vermont; West Virginia; Work; aging population; cohort; comorbidity; coronavirus disease; data resource; data submission; experience; improved; investigator training; mortality; novel coronavirus; operation; programs; research study

Since the emergence of the novel coronavirus (SARS-Cov-2) in the United States, more than 33 million cases have been confirmed, and the death toll has climbed to over 600,000 persons. The Institutional Development Award Program (IDeA) Clinical and Translational Research Centers (CTRs) are located in diverse areas of the US, serving rural populations as well as other underserved groups, including Native Americans, Hispanic individuals, and persons of color. Many states served by IDeA-CTRs have been among those hardest hit by the COVID-19 pandemic. The National COVID Cohort Collaborative (N3C) has been established by the National Center for Data to Health (CD2H) in partnership with the National Center for Advancing Translational Sciences (NCATS) as a centralized national data resource for the study of COVID- 19. Over the past year, the 8 IDeA-CTRs participating in National COVID Cohort Collaborative (N3C) have contributed electronic health record (EHR) data on more than 175,000 individuals infected with SARS-COV-2. IDeA-CTR investigators have led multiple N3C Domain Teams, participated in many data projects, and engaged more than 150 IDeA state investigators across the US. Moreover, N3C has served as a stimulus for the IDeA CTRs to work as a highly collaborative network. IDeA CTRs are now well poised to build on this experience to enable inclusion of EHRs from additional areas of the United States, broaden engagement of diverse investigators throughout IDeA states, and most importantly, to drive science relevant to minority and underserved IDeA state populations with communication of results to those communities. We will accomplish these broad objectives through the following aims: Aim 1 - Build IDeA-CTR infrastructure to organize collaboration among IDeA CTRs for purposes of driving relevant science; AIM 2 - Expand IDeA-CTR data contributions to N3C, thereby, increasing representation of minority, rural, and other underserved populations in the N3C dataset; Aim 3 - Provide the necessary analytic support to conduct cutting-edge big data research using a range of techniques, including machine learning (ML) and artificial intelligence (AI), to answer important research questions regarding impact of SARS-CoV-2 in IDeA states; and Aim 4 - Actively engage investigators in IDeA states to enable conduct of high quality COVID-19 data projects (through N3C) relevant to populations in their respective states while facilitating investigator development.

自从美国出现新颖的冠状病毒（SARS-COV-2）以来，超过33 已经确认了百万案件，死亡人数已攀升至60万人。这 机构发展奖计划（IDEA）临床和转化研究中心 （CTR）位于美国的不同地区，服务于农村人口以及其他地区 服务不足的团体，包括美洲原住民，西班牙裔人和有色人种。 IDEA-CTR服务的许多州一直是Covid-19的最艰难的人之一 大流行。国家共同队列合作（N3C）已由国家建立 卫生数据中心（CD2H）与国家前进中心合作 转化科学（NCAT）作为研究研究的集中式国家数据资源 19。在过去的一年中，参加国家共同队列合作的8个Idea-ctrs （N3C）对超过175,000个人贡献了电子健康记录（EHR）数据 感染SARS-COV-2。 Idea-CTR调查人员领导了多个N3C域团队， 参加了许多数据项目，并参与了150多名IDEA州调查员 美国。此外，N3C还刺激了CTR的想法 协作网络。 IDEA CTR现在已经准备好以这种体验为基础来启用 包括来自美国其他领域的EHR，扩大了不同的参与 整个思想状态的调查人员，最重要的是，推动科学与少数群体相关的科学 以及服务不足的思想国家人口与这些社区的结果交流。我们 将通过以下目的实现这些广泛的目标：目标1-构建Idea -CTR 为了驾驶相关目的，基础架构组织CTR之间的协作 科学; AIM 2-将IDEA -CTR数据贡献扩展到N3C，从而增加表示形式 N3C数据集中的少数民族，农村和其他服务不足的人群；目标3-提供 必要的分析支持，以使用一系列技术进行尖端的大数据研究， 包括机器学习（ML）和人工智能（AI），以回答重要的研究 关于SARS-COV-2在思想状态中的影响的问题；目标4-积极参与 思想状态的调查人员能够实现高质量的Covid-19数据项目（通过 N3C）与各自州的人口有关，同时促进研究人员的发展。