Wadsworth Center's Human Health and Exposure Analysis Resource (WC-HHEAR)

沃兹沃斯中心的人类健康和暴露分析​​资源 (WC-HHEAR)

• 批准号: 10876657
• 负责人: Kurunthachalam Kannan
• 金额: $ 94.68万
• 依托单位: WADSWORTH CENTER
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-30 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10876657
• 关键词: Amniotic Fluid; Analytical Chemistry; Aromatic Amines; Aromatic Polycyclic Hydrocarbons; Arsenic; Biological Assay; Biological Markers; Biological Monitoring; Birth; Bladder; Blood; Cadmium; Chemicals; Child; Child Health; Childhood; Copper; Coupled; DNA Markers; Dryness; Elements; Environmental Exposure; Environmental Health; Environmental Pollutants; Exposure to; Flame Retardants; Folic Acid; Funding; Goals; Hair; Health; Human; Human Milk; Inductively Coupled Plasma Mass Spectrometry; Infrastructure; Laboratories; Lanthanoid Series Elements; Lead; Life Style; Link; Lipids; Liquid substance; Measurement; Measures; Melamine; Mercury; Metabolism; Methylation; Micronutrients; Nail plate; New York; Nutritional; Opioid; Organic Chemicals; Outcome; Outcome Study; Oxidative Stress; Pesticides; Pharmaceutical Preparations; Phytoestrogens; Placenta; Plasma; Polychlorinated Biphenyls; Pregnancy; Proteins; Public Health; Rare Earth Metals; Research Institute; Resources; Saliva; Sampling; Selenium; Series; Serum; Specific Gravity; Specimen; Spottings; Stress; Tissues; Tobacco smoke; Tooth structure; Trace Elements; Umbilical Cord Blood; United States National Institutes of Health; Urine; Whole Blood; Work; World Health; Zinc; analog; cohort; early childhood; early life exposure; environmental chemical; experience; human tissue; neurodevelopment; novel; organic contaminant; persistent organic pollutants; phthalates; postnatal; prenatal; prenatal exposure; programs; pulmonary function; success; toxic metal

PROJECT SUMMARY / ABSTRACT The overall objective of this supplement proposal is to provide the Wadsworth Center’s Human Health and Exposure Analysis Resource (WC-HHEAR) the resources to support unanticipated additional work associated with five additional new Analysis Concepts (projects) for the Environmental Contributors to Children’s Health Outcomes (ECHO) program. These projects comprise multi-cohort-based studies of children’s exposure to environmental chemicals. WC-HHEAR provides ECHO with access to state-of-the-art analyses for exploring the effects of environmental contaminants on children’s health. WC-HHEAR’s extensive infrastructure, expertise, and reputation as a world-class biomonitoring laboratory is located in the NY State Department of Health’s Wadsworth Center. Within the Center’s Division of Environmental Health Sciences (DEHS), two analytical lab groups analyze biospecimens for environmental contaminants: the Trace Elements Lab (TREL) and the Biomonitoring Organic Analytical Chemistry (BOAC) Lab. Dr. Patrick Parsons is the Director of DEHS overseeing the TREL, while Dr. Kurunthlachalam Kannan is Deputy Director of DEHS overseeing the BOAC. Together, Drs. Parsons and Kannan (the MPIs of this supplement proposal) have more than 75 years of combined experience in analytical chemistry applied to measuring environmental contaminants in human tissues and fluids. The BOAC analyzes biospecimens for 30 classes of trace organic contaminants totaling hundreds of analytes including polychlorinated biphenyls, polycyclic aromatic hydrocarbons, perfluorinated compounds, brominated flame retardants, pesticides, phthalates (including metabolites, replacements and emerging chemicals), drugs (e.g., opioids), biomarkers of stress (e.g., oxidative stress markers of DNA, protein and lipids), life style biomarkers (e.g., tobacco smoke) and nutritional biomarkers (e.g., phytoestrogens, micronutrients). The TREL group analyzes biospecimens for up to 22 trace elements that include toxic (lead, cadmium, mercury, and arsenic) and essential (copper, selenium, zinc) elements in whole blood, urine, and serum/plasma, plus the 16 rare earth elements, which includes the lanthanides series. Both BOAC and TREL have extensive expertise analyzing non- traditional matrices such as placenta, cord blood, baby teeth, dried blood spots, hair, nails, amniotic fluid, breast milk, saliva, and other tissues. This supplement leverages Wadsworth’s capacity and capability to provide high complexity laboratory analyses to support five new ECHO projects: ECHO Project EC0655 – Impact of early childhood exposures to novel chemicals on neurodevelopmental outcomes; ECHO Project EC0656 – Early life exposures to melamine, melamine analogs, and aromatic amines in relation with neurodevelopment; ECHO Project EC0661 – Maternal Folate Status During Pregnancy, Arsenic Metabolism, and Birth Outcomes; ECHO Project EC0669 – Prenatal exposure to arsenic and lung function in children: An ECHO program study; and ECHO Project EC0668 – Pre-and postnatal arsenic exposure, arsenic methylation efficiency, and childhood neurodevelopment: An ECHO program study.

项目概要/摘要 该补充提案的总体目标是为沃兹沃斯中心的人类健康和 暴露分析资源 (WC-HHEAR) 用于支持意外的额外相关工作的资源 为儿童健康环境贡献者提供五个额外的新分析概念（项目） 结果 (ECHO) 计划包括针对儿童接触情况的多队列研究。 WC-HHEAR 为 ECHO 提供了最先进的分析方法来探索环境化学品。 WC-HHEAR 广泛的基础设施、专业知识、 享有世界级生物监测实验室声誉的纽约州卫生部 沃兹沃斯中心的环境健康科学部 (DEHS) 内设有两个分析实验室。 小组分析生物样本中的环境污染物：微量元素实验室 (TREL) 和 Patrick Parsons 博士是 DEHS 的生物监测有机分析化学 (BOAC) 实验室主任。 TREL 博士，而 Kurunthlachalam Kannan 博士是负责监督 BOAC 的 DEHS 副主任。 Parsons 和 Kannan（本补充提案的 MPI）拥有超过 75 年的综合经验 分析化学专业用于测量人体组织和体液中的环境污染物。 30 类痕量有机污染物的生物样本，总计数百种分析物，包括 多氯联苯、多环芳香烃、全氟化合物、溴化火焰 阻燃剂、杀虫剂、邻苯二甲酸盐（包括代谢物、替代品和新兴化学品）、药物（例如， 阿片类药物）、压力生物标志物（例如 DNA、蛋白质和脂质的氧化应激标志物）、生活方式生物标志物 （例如烟草烟雾）和营养生物标志物（例如植物雌激素、微量营养素）。 多达 22 种微量元素的生物样本，其中包括有毒物质（铅、镉、汞和砷）和 全血、尿液和血清/血浆中的必需元素（铜、硒、锌），以及 16 种稀土 BOAC 和 TREL 都拥有丰富的非元素分析专业知识。 传统基质，如胎盘、脐带血、乳牙、干血斑、头发、指甲、羊水、乳房 该补充剂利用了沃兹沃斯的能力和能力来提供高浓度。 复杂性实验室分析支持五个新的 ECHO 项目： ECHO 项目 EC0655 – 早期的影响 儿童时期接触新型化学物质对神经发育结果的影响；ECHO 项目 EC0656 – 早期生活 接触三聚氰胺、三聚氰胺类似物和芳香胺与 ECHO 的关系； EC0661 项目 – 怀孕期间母亲叶酸状况、砷代谢和出生结果； EC0669 项目 – 儿童产前砷暴露与肺功能：一项 ECHO 计划研究； ECHO 项目 EC0668 – 产前和产后砷暴露、砷甲基化效率和儿童期 神经发育：ECHO 项目研究。

项目成果

Urinary and fecal excretion of aromatic amines in pet dogs and cats from the United States.

• DOI: 10.1016/j.envint.2022.107208
• 发表时间: 2022-05
• 期刊: ENVIRONMENT INTERNATIONAL
• 影响因子: 11.8
• 作者: Chinthakindi, Sridhar;Kannan, Kurunthachalam
• 通讯作者: Kannan, Kurunthachalam

1,3-Diphenylguanidine, benzothiazole, benzotriazole, and their derivatives in soils collected from northeastern United States.

从美国东北部收集的土壤中的 1,3-二苯胍、苯并噻唑、苯并三唑及其衍生物。

• DOI: 10.1016/j.scitotenv.2023.164110
• 发表时间: 2023
• 期刊: The Science of the total environment
• 作者: Li,Zhong-Min;Pal,VineetKumar;Kannan,Pranav;Li,Wenlong;Kannan,Kurunthachalam
• 通讯作者: Kannan,Kurunthachalam

Occurrence of and dermal exposure to benzene, toluene and styrene in sunscreen products marketed in the United States.

在美国销售的防晒产品中苯、甲苯和苯乙烯的存在和皮肤暴露。

• DOI: 10.1016/j.scitotenv.2023.164196
• 发表时间: 2023
• 期刊: The Science of the total environment
• 作者: Pal,VineetKumar;Lee,Sunmi;Kannan,Kurunthachalam
• 通讯作者: Kannan,Kurunthachalam

Per- and polyfluoroalkyl substances and psychosocial stressors have a joint effect on adverse pregnancy outcomes in the Atlanta African American Maternal-Child cohort.

全氟烷基物质和多氟烷基物质以及社会心理压力源对亚特兰大非裔美国母婴队列中的不良妊娠结局具有共同影响。

• DOI: 10.1016/j.scitotenv.2022.159450
• 发表时间: 2023
• 期刊: The Science of the total environment
• 作者: Eick,StephanieM;Barr,DanaBoyd;Brennan,PatriciaA;Taibl,KaitlinR;Tan,Youran;Robinson,Morgan;Kannan,Kurunthachalam;Panuwet,Parinya;Yakimavets,Volha;Ryan,PBarry;Liang,Donghai;Dunlop,AnneL
• 通讯作者: Dunlop,AnneL

Simultaneous quantification of urinary tobacco and marijuana metabolites using solid-supported liquid-liquid extraction coupled with liquid chromatography tandem mass spectrometry.

• DOI: 10.1016/j.jchromb.2022.123378
• 发表时间: 2022-10-01
• 期刊: JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
• 影响因子: 3
• 作者: Yakimavets, Volha;Qiu, Tian;Panuwet, Parinya;D'Souza, Priya E.;Brennan, Patricia A.;Dunlop, Anne L.;Ryan, P. Barry;Barr, Dana Boyd
• 通讯作者: Barr, Dana Boyd