MASDA-X--AN OPTIMIZED FLAT-PANEL DIGITAL X-RAY IMAGER

MASDA-X——优化的平板数字 X 射线成像仪

• 批准号: 2443011
• 负责人: LARRY E ANTONUK
• 金额: $ 70.93万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-07-24 至 1999-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2443011
• 关键词: amorphous solid; angiography; biomedical equipment development; digital imaging; fluoroscopy; phantom model; radiation detector; silicon

This application proposes an ambitious program of research to develop a new, real-time, digital, flat-panel imaging technology based upon a Multi- element Amorphous Silicon Detector Array for X-ray imaging (MASDA-X). The radiation-resistant array will consist of a 2-dimensional, self-scanning matrix of 2500 x 2500 pixels at a pixel pitch of 100 microns giving a 25 x 25 cm square imaging area. The imager consists of an x-ray converter, the array, and the associated acquisition electronics. Such imagers offer significant potential advantages over existing technologies including: (a) digital radiographic imaging with immediate image capture and presentation at equivalent or perhaps even considerably less exposure than film-screen and CR systems: (b) real-time fluoroscopic imaging with a compact unit the size of a film-cassette and with image quality free of the effects of distortion and glare that affect x-ray image intensifier (XRII) systems; (c) exposure and dynamic range comparable to that of CR systems and large compared to film-screen systems; (d) a spatial resolution of 5 l p/mm which is superior to that of existing XRII units; and (e) low cost devices offering low-maintenance and assured quality imaging. The overall objective of this research is to determine if flat-panel technology is capable of creating imaging devices with performance comparable or superior to established technologies (eg. film-screen and CR for radiography and XRII systems for fluoroscopy). The specific aims of the research are: (l) development of the imaging system in a manner so as to optimize imaging performance separately for radiography and fluoroscopy. The optimization method will involve an iterative procedure of imager construction, performance evaluation, theoretical modeling, and design improvement; (2) creation of the acquisition electronics necessary to allow optimal signal-to-noise performance of the imager and execution of the imager studies; (3) thorough quantification of the performance of the imager through measurement of its properties including observer- independent performance variables: MTF(f), DQE(f), and NPS(f) to determine how the signal and noise properties of this imager compare to those of existing technologies; (4) execution of initial quantitative examination of the possible clinical utility of the imager through observer-dependent studies comparing the performance of the flat-panel imager to that of state-of-the-art film-screen, CR, and XRII systems employing a variety of phantoms. If the performance of flat-panel x-ray imagers can be made acceptable, their potential advantages are such that this technology could become a major radiological tool early in the 21st century with a correspondingly profound impact upon health care. The proposed research will answer the essential questions of whether imagers built from this technology offer quantitative performance comparable or superior to current established technologies and thus warrant the massive investments that will be required to bring such matters into clinical use.

该申请提出了一项雄心勃勃的研究计划，旨在开发一种 基于 Multi-Panel 的新型实时数字平板成像技术 用于 X 射线成像的非晶硅探测器阵列 (MASDA-X)。 这 抗辐射阵列将由一个二维自扫描 2500 x 2500 像素的矩阵，像素间距为 100 微米，给出 25 x 25 厘米见方的成像区域。 成像仪由 X 射线转换器、 阵列和相关的采集电子设备。 此类成像仪提供 与现有技术相比具有显着的潜在优势，包括：(a) 具有即时图像捕获和呈现功能的数字放射线成像 与胶片屏幕的曝光量相当或什至少得多 和 CR 系统：(b) 具有紧凑型装置的实时荧光镜成像 胶片盒的大小和图像质量不受 影响 X 射线图像增强器 (XRII) 系统的畸变和眩光； (c) 曝光和动态范围与 CR 系统和大型系统相当 与电影屏幕系统相比； (d) 空间分辨率为 5 l p/mm 优于现有 XRII 装置； (e) 低成本 设备维护成本低且成像质量有保证。 整体 这项研究的目的是确定平板技术是否 能够创建具有可比或性能相当的成像设备 优于现有技术（例如胶片屏幕和 CR 用于荧光检查的放射线照相和 XRII 系统）。 该计划的具体目标 研究内容是： (l) 开发成像系统，以便 分别优化射线照相和透视的成像性能。 优化方法将涉及成像仪的迭代过程 施工、性能评估、理论建模和设计 改进; (2) 创建必要的采集电子设备 允许成像仪的最佳信噪比性能和执行 成像仪研究； (3) 全面量化绩效 成像仪通过测量其属性，包括观察者 独立性能变量：MTF(f)、DQE(f) 和 NPS(f) 来确定 该成像仪的信号和噪声特性与 现有技术； (4) 初次定量检验的执行 通过依赖观察者来评估成像仪可能的临床效用 研究比较平板成像仪与 最先进的电影屏幕、CR 和 XRII 系统，采用各种 幻影。 如果平板X射线成像仪的性能能够实现 可以接受，它们的潜在优势是该技术可以 成为 21 世纪初主要的放射工具 相应地，对医疗保健也产生了深远的影响。 拟议的研究 将回答是否以此为基础构建成像器的基本问题 技术提供的定量性能可与或优于 当前成熟的技术，因此需要大量投资 将这些物质投入临床使用是必需的。