A Clinical High Resolution Imaging System (CHRIS)

临床高分辨率成像系统 (CHRIS)

• 批准号: 7612538
• 负责人: RODERICK J LOEWEN
• 金额: $ 129.64万
• 依托单位: LYNCEAN TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7612538
• 关键词: Animal Experiments; Animals; Architecture; Arts; Biomedical Research; Cancer Detection; Clinical; Clinical Trials; Clinics and Hospitals; Computer software; Coronary Angiography; Data Collection; Degenerative polyarthritis; Detection; Development; Devices; Diagnosis; Diagnostic; Diagnostic Imaging; Diagnostic radiologic examination; Disease; Dose; Dose-Rate; Early Diagnosis; Elements; Energy-Generating Resources; Engineering; Equipment; Equipment Design; Freedom; Funding; Generations; Grant; Health; Hour; Human; Image; Image Analysis; Imagery; Imaging Device; Imaging Phantoms; Imaging Techniques; Imaging technology; Institutes; Laboratories; Laboratory Research; Light; Mammary Gland Parenchyma; Mammography; Methods; Motion; National Institute of General Medical Sciences; Output; Patients; Phase; Property; Protein Structure Initiative; Research; Research Personnel; Resolution; Sampling; Scientist; Screening for cancer; Simulate; Small Business Innovation Research Grant; Source; Staging; Structure; Switzerland; Synchrotrons; System; Techniques; Technology; Testing; Time; Tissue Sample; Variant; Work; Writing; absorption; animal tissue; bioimaging; cancer imaging; clinical application; cost; density; design; digital imaging; engineering design; image reconstruction; imaging modality; improved; in vivo; innovation; innovative technologies; instrument; malignant breast neoplasm; optical imaging; prototype; public health relevance; research study; soft tissue; tomography; tumor; two-dimensional

DESCRIPTION (provided by applicant): We propose to develop an innovative prototype imaging system which combines the unique properties of the Compact Light Source (a new x-ray source developed with NIGMS SBIR funding) with a new imaging method called Differential Phase Contrast Imaging. This Clinical High Resolution Imaging System (CHRIS) will yield x-ray images which can distinguish subtle variations in soft tissue at an extremely fine scale. The Compact Light Source (CLS), developed with a grant from the Protein Structure Initiative of the NIGMS, is a high-intensity, tunable synchrotron light source that is small enough for clinical implementation. DPCI is an elegant new imaging technology that has demonstrated superior visualization of soft tissue using x-rays. Image contrast for DPCI is caused by the phase shift of x-rays passing through the subject and therefore does not rely upon absorption as with conventional x-ray techniques. The DPCI technique provides three improved contrast mechanisms to reveal specific soft tissue detail not revealed in standard radiographs: higher-quality absorption contrast arising from the nearly monochromatic point-like x-ray source; phase contrast that highlights the density variation of soft tissue; and dark-field contrast which accentuates small-angle scattering from the fine structure of soft tissue. DPCI, as a transmissive technique, also favors high-energy x-rays (30 keV or higher) that can significantly reduce the absorbed dose received by the patient over conventional x-ray techniques. CHRIS is intended to integrate these two innovative technologies-the CLS and DPCI-to produce a turnkey system for both 2-D and tomographic imaging of phantoms and tissue samples with all of the degrees of freedom necessary to simulate the motions required for clinical applications; it will be implemented with the intent of later handling patients without significant re-engineering. When complete, the CHRIS will be a product which will enable the development of clinical applications of this new method towards cancer detection, mammography, osteoarthritis, small animal imaging and other clinical radiological applications which require the detection of fine structure within soft tissue. The CHRIS proposal seeks to develop a new, versatile state-of-the-art instrument to enable both basic biomedical research and clinical investigations of a wide range of health issues. PUBLIC HEALTH RELEVANCE: The proposed Clinical High Resolution Imaging System (CHRIS) will extend the power of present x-ray diagnostic imaging by employing new contrast mechanisms to show extremely fine details within soft tissue that conventional radiography cannot reveal. This improved x-ray imaging would enable researchers to better understand disease and therapies and help to diagnose and treat disease at the earliest detectable stage. CHRIS will be a new state-of-the-art instrument to enable both basic biomedical research and clinical investigations of a wide range of health issues, including the early detection of cancer, in vivo imaging of small animals, as well as other soft tissue applications.

描述（由申请人提供）：我们建议开发一种创新的原型成像系统，该系统结合了紧凑型光源的独特属性（一种带有NIGMS SBIR资金开发的新X射线源）和一种称为差异相比成像的新成像方法。该临床高分辨率成像系统（CHRIS）将产生X射线图像，可以以极高的规模区分软组织的细微变化。紧凑型光源（CLS）是由Nigms蛋白质结构倡议的赠款开发的，是一种高强度，可调的同步子光源，足够小，足以临床实施。 DPCI是一种优雅的新成像技术，它显示了使用X射线对软组织的出色可视化。 DPCI的图像对比是由X射线穿过受试者的相移引起的，因此不依赖于传统X射线技术的吸收。 DPCI技术提供了三种改进的对比机制，以揭示标准X光片中未揭示的特定软组织细节：由几乎单色点样X射线源引起的更高质量的吸收对比；相比，突出了软组织的密度变化；和暗场对比，从软组织的精细结构中加入了小角度的散射。 DPCI作为一种传播技术，也有利于高能X射线（30 KEV或更高），可以显着降低患者接受的吸收剂量，而不是常规的X射线技术。 Chris旨在将这两种创新技术（CLS和DPCI）整合在一起，以生成用于幻象和组织样品的2-D和层析成像的交钥匙系统，以及模拟临床应用所需的动作所需的所有自由度；它将以后来处理患者而无需重新设计的患者进行实施。完成后，克里斯将成为一种产品，它将能够开发这种新方法用于癌症检测，乳房X线摄影，骨关节炎，小动物成像和其他临床放射学应用，这些应用需要检测软组织内的细胞结构。克里斯提案旨在开发一种新的，多功能的最先进的工具，以实现对广泛健康问题的基本生物医学研究和临床研究。公共卫生相关性：拟议的临床高分辨率成像系统（CHRIS）将通过采用新的对比度机制来扩展当前X射线诊断成像的功能，以在软组织中显示出非常细节的细节，而常规X射线照相无法揭示。这种改进的X射线成像将使研究人员能够更好地理解疾病和疗法，并有助于在最早的可检测阶段诊断和治疗疾病。克里斯将是一种新的最先进的工具，旨在使基本的生物医学研究和临床研究对广泛的健康问题进行临床研究，包括早期发现癌症，体内小动物的体内成像以及其他软组织应用。