The Ohio State University Vision Sciences Research Core Program (OSU-VSRCP)

俄亥俄州立大学视觉科学研究核心计划 (OSU-VSRCP)

• 批准号: 10707323
• 负责人: Sayoko E Moroi
• 金额: $ 57.12万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-30 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10707323
• 关键词: Agreement; Angiography; Animal Model; Architecture; Artificial Intelligence; Arts; Bioinformatics; Biometry; Blindness; Cell model; Clinical Research; Collaborations; Communities; Computers; Core Facility; Data; Data Analyses; Data Commons; Data Science; Data Science Core; Data Set; Data Storage and Retrieval; Development; Electrophysiology (science); Engineering; Ensure; Environment; Equipment; Evaluation; Eye diseases; Faculty; Faculty Recruitment; Funding; Fundus photography; Genes; Genetic; Genomics; Goals; Health Services; Health Services Research; High Performance Computing; Human; Image Analysis; Individual; Institution; Interdisciplinary Study; Lasers; Leadership; Learning; Letters; Machine Learning; Medical center; Medicine; Microscope; Morphology; Neurosciences; Ohio; Ophthalmology; Optometry; Outcome; Pathway Analysis; Pediatric Hospitals; Pediatrics; Procedures; Protocols documentation; Psychology; Research; Research Design; Research Personnel; Research Project Grants; Resources; Science; Scientist; Service delivery model; Services; Strategic Planning; Surveys; System; Technical Expertise; Thinking; Training; Universities; Variant; Veterinary Medicine; Vision; Vision research; advanced analytics; analytical tool; biomedical informatics; clinical translation; cluster computing; college; computer science; cost; data mining; design; equipment acquisition; flexibility; genetic analysis; genomic data; high standard; image guided; image processing; implementation science; manufacture; meetings; model organism; prevent; programs; recruit; research facility; response; sight restoration; statistics; supercomputer; synergism; tonometry; vision science

OVERALL MULTI-COMPONENT NEI P30 PROPOSAL abstract The Ohio State University Vision Sciences Research Core Program (OSU-VSRCP) has established the expanding vision research scientists across five academic units (i.e., College of Medicine (COM), College of Optometry (COO), College of Engineering (COE), College of Veterinary Medicine, College of Arts and Sciences) and newly engaged Nationwide Children’s Hospital. Program Director (PD) Dr. Moroi has commitment from Deans and Chairs to purchase equipment (i.e., confocal microscope), support data science, assign scarce space, and increase collaborations. The leadership and scientists are aligned with the NEI PAR- 20-051 ‘to enhance the capabilities of participating NEI-funded investigators and the institution for conducting vision research.’ Synergy of this community has been established with monthly ViSOR (Vision Sciences OSU Research) seminars. Synergy between Cores has been defined by the Steering Committee composed of the PD, Core Directors and Co-directors, who represent Dept. Ophthalmology and Visual Sciences (DOVS), Dept. Neuroscience, Dept. Biomedical Informatics, Dept. Computer Science (COE), and COO. Synergy between Cores will coincide with monthly ViSOR meetings. In addition, an Advisory Group will provide guidance twice a year to the Steering Committee. Based on a survey of 61 scientists, three scientific cores are proposed, which are re-organized in response to the prior review led by a Director and Co-director, with at least one of the leaders holding an NEI R01. Core A: Structural and Functional Assessments (SFA) Core A provides technical expertise and well-maintained state-of-the-art equipment for functional and morphological assessment of cells and animal models used in vision research. Dr. Moroi arranged the added value of machine shop services with an agreement with Executive Director Mr. Nate Ames (see letter) of The OSU Center for Design and Manufacturing Excellence (CDME) to enhance funded research projects. Core B: Biostatistics, Bioinformatics and Genetic Analysis (BBGA) Core B was re-organized to consolidate services for traditional statistics and statistical genetics. Users can obtain assistance in research design and traditional statistics, as well as bioinformatics, pathway analysis, and large-scale genomic data mining that require advanced computational analytics. Core C: Image Analysis and Data Science (IADS) Core C was re- organized in response to the growing need for image processing, analysis and data science expertise including machine learning and artificial intelligence (AI) and development of a Data Commons Architecture for the OSU vision community. The expected outcome is increased collaboration for successful new proposals with the shared overarching goal to prevent blindness, restore vision and develop cures for eye diseases.

整体多组件 NEI P30 提案摘要 俄亥俄州立大学视觉科学研究核心计划 (OSU-VSRCP) 建立了 视觉研究科学家遍布扩展的五个学术单位（即医学院（COM）、医学院 验光学院 (COO)、工程学院 (COE)、兽医学院、艺术学院 科学）和新聘任的全国儿童医院项目总监 (PD) Moroi 博士。 院长和主席承诺购买设备（即共焦显微镜），支持数据科学， 分配稀缺空间，并加强合作 领导层和科学家与 NEI PAR 保持一致。 20-051‘增强参与 NEI 资助的调查人员和机构进行研究的能力 该社区的协同作用已通过每月 ViSOR（俄勒冈州立大学视觉科学 研究）研讨会由指导委员会定义了核心之间的协同作用。 PD、核心主任和联合主任，代表眼科和视觉科学系 (DOVS)、Dept. 神经科学系、生物医学信息学系、计算机科学系 (COE) 和 COO 之间的协同作用。 核心会议将与每月的 ViSOR 会议同时进行。此外，咨询小组将每年提供两次指导。 根据对 61 名科学家的调查，提出了三项科学核心，即 根据董事和联席董事领导的事先审查进行重组，其中至少有一名董事 持有 NEI R01 核心 A 的领导者：结构和功能评估 (SFA) 核心 A 提供。 技术专业知识和维护良好的最先进的功能和形态设备 Moroi 博士安排了对视觉研究中使用的细胞和动物模型的评估。 与 OSU 执行董事 Nate Ames 先生达成协议（见信件）的机加工车间服务 卓越设计与制造中心 (CDME) 加强资助的核心 B 项目： 生物统计学、生物信息学和遗传分析（BBGA）核心B进行重组以巩固 用户可以在研究设计和统计遗传学方面获得帮助。 传统的统计学，以及生物信息学、通路分析和大规模基因组数据挖掘 需要高级计算分析 核心 C：图像分析和数据科学 (IADS) 核心 C 被重新设计。 组织的目的是为了满足对图像处理、分析和数据科学专业知识日益增长的需求，包括 机器学习和人工智能 (AI) 以及为 OSU 开发数据共享架构 预期成果是加强与成功新提案的合作。 共同的总体目标是预防失明、恢复视力和开发眼科疾病的治疗方法。