The Ohio State University Vision Sciences Research Core Program (OSU-VSRCP)

俄亥俄州立大学视觉科学研究核心计划 (OSU-VSRCP)

• 批准号: 10707323
• 负责人: Sayoko E Moroi
• 金额: $ 57.12万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-30 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10707323
• 关键词: Agreement; Angiography; Animal Model; Architecture; Artificial Intelligence; Arts; Bioinformatics; Biometry; Blindness; Cell model; Clinical Research; Collaborations; Communities; Computers; Core Facility; Data; Data Analyses; Data Commons; Data Science; Data Science Core; Data Set; Data Storage and Retrieval; Development; Electrophysiology (science); Engineering; Ensure; Environment; Equipment; Evaluation; Eye diseases; Faculty; Faculty Recruitment; Funding; Fundus photography; Genes; Genetic; Genomics; Goals; Health Services; Health Services Research; High Performance Computing; Human; Image Analysis; Individual; Institution; Interdisciplinary Study; Lasers; Leadership; Learning; Letters; Machine Learning; Medical center; Medicine; Microscope; Morphology; Neurosciences; Ohio; Ophthalmology; Optometry; Outcome; Pathway Analysis; Pediatric Hospitals; Pediatrics; Procedures; Protocols documentation; Psychology; Research; Research Design; Research Personnel; Research Project Grants; Resources; Science; Scientist; Service delivery model; Services; Strategic Planning; Surveys; System; Technical Expertise; Thinking; Training; Universities; Variant; Veterinary Medicine; Vision; Vision research; advanced analytics; analytical tool; biomedical informatics; clinical translation; cluster computing; college; computer science; cost; data mining; design; equipment acquisition; flexibility; genetic analysis; genomic data; high standard; image guided; image processing; implementation science; manufacture; meetings; model organism; prevent; programs; recruit; research facility; response; sight restoration; statistics; supercomputer; synergism; tonometry; vision science

OVERALL MULTI-COMPONENT NEI P30 PROPOSAL abstract The Ohio State University Vision Sciences Research Core Program (OSU-VSRCP) has established the expanding vision research scientists across five academic units (i.e., College of Medicine (COM), College of Optometry (COO), College of Engineering (COE), College of Veterinary Medicine, College of Arts and Sciences) and newly engaged Nationwide Children’s Hospital. Program Director (PD) Dr. Moroi has commitment from Deans and Chairs to purchase equipment (i.e., confocal microscope), support data science, assign scarce space, and increase collaborations. The leadership and scientists are aligned with the NEI PAR- 20-051 ‘to enhance the capabilities of participating NEI-funded investigators and the institution for conducting vision research.’ Synergy of this community has been established with monthly ViSOR (Vision Sciences OSU Research) seminars. Synergy between Cores has been defined by the Steering Committee composed of the PD, Core Directors and Co-directors, who represent Dept. Ophthalmology and Visual Sciences (DOVS), Dept. Neuroscience, Dept. Biomedical Informatics, Dept. Computer Science (COE), and COO. Synergy between Cores will coincide with monthly ViSOR meetings. In addition, an Advisory Group will provide guidance twice a year to the Steering Committee. Based on a survey of 61 scientists, three scientific cores are proposed, which are re-organized in response to the prior review led by a Director and Co-director, with at least one of the leaders holding an NEI R01. Core A: Structural and Functional Assessments (SFA) Core A provides technical expertise and well-maintained state-of-the-art equipment for functional and morphological assessment of cells and animal models used in vision research. Dr. Moroi arranged the added value of machine shop services with an agreement with Executive Director Mr. Nate Ames (see letter) of The OSU Center for Design and Manufacturing Excellence (CDME) to enhance funded research projects. Core B: Biostatistics, Bioinformatics and Genetic Analysis (BBGA) Core B was re-organized to consolidate services for traditional statistics and statistical genetics. Users can obtain assistance in research design and traditional statistics, as well as bioinformatics, pathway analysis, and large-scale genomic data mining that require advanced computational analytics. Core C: Image Analysis and Data Science (IADS) Core C was re- organized in response to the growing need for image processing, analysis and data science expertise including machine learning and artificial intelligence (AI) and development of a Data Commons Architecture for the OSU vision community. The expected outcome is increased collaboration for successful new proposals with the shared overarching goal to prevent blindness, restore vision and develop cures for eye diseases.

总体多组分NEI P30提案摘要 俄亥俄州立大学愿景科学研究核心计划（OSU-VSRCP）已建立 扩大五个学术单位的视力研究科学家（即医学院（COM），学院 验光（COO），工程学院（COE），兽医学院，艺术学院， 科学）和新订婚的全国儿童医院。项目总监（PD）Moroi博士 院长和椅子的承诺购买设备（即共聚焦显微镜），支持数据科学， 分配稀缺空间并增加协作。领导力和科学家与Nei Pars吻合 20-051‘为了增强参与的NEI资助的调查人员和进行的机构的能力 视觉研究。’该社区的协同作用是通过每月遮阳板建立的（视觉科学OSU 研究）半货人。核心之间的协同作用是由指导委员会定义的 PD，核心主管和联合导演，代表眼科和视觉科学部（DOVS），部门。 神经科学，生物医学信息学系，计算机科学系（COE）和COO。之间的协同作用 核心将与每月的遮阳板会议一致。此外，咨询小组将两次提供指导 指导委员会的一年。根据对61位科学家的调查，提出了三个科学核心，这是 响应由董事和联合导演领导的先前审查，重新组织，至少有一个 持有NEI R01的领导人。核心A：结构和功能评估（SFA）核心A提供 技术专长以及功能和形态的最先进的设备 评估视觉研究中使用的细胞和动物模型。莫罗伊博士安排了 与执行董事Nate Ames先生（见信函）达成协议的机械车间服务 设计与制造业卓越中心（CDME），以增强资助的研究项目。核心B： 重新组织生物统计学，生物信息学和遗传分析（BBGA）核心B 传统统计和统计遗传学的服务。用户可以在研究设计方面获得帮助， 传统统计数据，生物信息学，途径分析和大规模基因组数据挖掘 需要高级计算分析。核心C：图像分析和数据科学（IADS）核心C是重新的 根据对图像处理，分析和数据科学专业知识的需求不断增长的响应 机器学习和人工智能（AI）以及OSU的数据共享体系结构的开发 愿景社区。预期的结果是增加协作与与 共同的总体目标，以防止失明，恢复视力和发展眼病的治疗方法。