Hip Strength Across the Menopausal Transition

更年期过渡时期的臀部力量

基本信息

批准号：
7848113
负责人：
JANE Ann CAULEY
金额：
$ 42.36万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-06-01 至 2012-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7848113
关键词：
3-Dimensional Address Adult Affect African American Age Age-Related Bone Loss Aging Alcohol consumption Alcohols Architecture Area Asians Biological Body Composition Body Height Body Size Body Weight Body Weights and Measures Body fat Bone Density Calcium Caucasians Caucasoid Race Chinese People Clinical Trials Communities Contraceptive Usage Data Development Elements Enrollment Equilibrium Estradiol Ethnic group Exercise Fatty acid glycerol esters Femur Fracture Goals Gonadal Steroid Hormones Height Hip Fractures Hip region structure Hispanics Hormones Image Intake Japanese Population Knowledge Life Style Light Limb structure Longitudinal Studies Lower Extremity Measures Menopausal Status Menopause Methods Modeling Muscle Rigidity NIH Program Announcements Nature Neck Obesity Osteoporosis Ovarian Ovarian hormone Participant Pattern Perimenopause Physical activity Physiological Population Attributable Risks Postmenopause Premenopause Principal Investigator Property Relative (related person)Reproductive History Research Research Design Research Personnel Risk Risk Reduction Roentgen Rays Sampling Scanning Serum Shapes Skeletal Muscle Smoke Smoking Spatial Distribution Structure Testing Testosterone Thick Universities Ursidae Family Waist-Hip Ratio Weight Weights and Measures Width Woman Women&apos s Health X-Ray Computed Tomography age related base bone bone mass bone quality bone strength bone turnover clinical research site cohort cost efficient density ethnic difference experience hormone deficiency hormone therapy improved in vivo indexing meetings middle age muscle form novel older women parity programs psychosocial sex skeletal socioeconomics

项目摘要

DESCRIPTION (provided by applicant): The proposed R-01 builds upon the Study of Woman's Health Across the Nation (SWAN) osteoporosis project. SWAN is a multi-center, longitudinal study, designed to characterize the biological and psychosocial changes that occur during the menopausal transition in a community-based sample of African-American, Caucasian, Chinese, Japanese, and Hispanic women. An overarching goal of SWAN is "to elucidate factors that differentiate women most susceptible to long-term pathophysiological consequences of ovarian hormone deficiency from women who are protected." One of the key physiological consequences of ovarian aging that was specifically targeted in SWAN was change in skeletal mass. Thus, five of the seven SWAN clinical sites are making annual measures of bone mineral density (BMD) by Dual X-ray Absorptiometry (DXA). All SWAN ethnic groups except the Hispanic women are represented in the SWAN bone project. However, BMD is only one of several factors that contribute to bone strength; bone structural properties including size, thickness, shape and spatial distribution of bone mass in a cross-section also contribute. Additionally, fractures result from an imbalance between bone strength and the load the bone bears. Thus, fracture risk depends on bone strength relative to the load it has to bear; the latter depends on body size. We propose to measure hip geometry and strength using the Hip Structural Analysis Program developed by Dr. Thomas Beck, and the Composite Strength Indices developed by Dr. Arun Karlamangla. We also propose to compare hip structural parameters and strength indices obtained from areal DXA scans with those obtained from 3-dimensional imaging using Quantitative Computed Tomography (QCT) on a subset of women. The specific aims of our study are to: 1) Determine the correlations between areal DXA based estimates of hip geometry and strength with QCT measures; 2) Determine the direction and magnitude of ethnic differences in femoral neck size, structure, and composite strength indices at baseline; 3) Identify predictors of baseline femoral neck size, structure, and strength; 4) Determine the rate of longitudinal change in femoral neck size and structural and composite strength indices with aging and with transition through menopause in different ethnic groups; 5) Identify factors associated with longitudinal changes in femoral neck size and strength indices and to compare their effects on size and strength with their effects on bone density; 6) Test the hypothesis that baseline femoral neck size and structural and composite strength indices predict incident fracture risk in midlife women. Our long-term objective is to substantially improve our understanding of the impact of aging and menopause on measures of hip size, structure, and strength in a well-characterized multiethnic cohort of mid-life women.

描述（由申请人提供）：拟议的 R-01 以全国妇女健康研究 (SWAN) 骨质疏松症项目为基础。 SWAN 是一项多中心纵向研究，旨在描述非裔美国人、白人、中国人、日本人和西班牙裔女性社区样本在更年期过渡期间发生的生物和心理社会变化。 SWAN 的首要目标是“阐明将最容易受到卵巢激素缺乏的长期病理生理后果影响的女性与受到保护的女性区分开来的因素”。 SWAN 专门针对的卵巢衰老的关键生理后果之一是骨骼质量的变化。因此，七个 SWAN 临床中心中的五个每年都会通过双 X 射线吸收测定法 (DXA) 测量骨矿物质密度 (BMD)。除西班牙裔女性外，所有 SWAN 族裔群体都参与了 SWAN 骨骼项目。然而，BMD 只是影响骨强度的几个因素之一；骨结构特性（包括横截面中骨量的大小、厚度、形状和空间分布）也有贡献。此外，骨折是由于骨强度和骨承受的负荷之间的不平衡造成的。因此，骨折风险取决于骨强度相对于其必须承受的负荷；后者取决于体型。我们建议使用 Thomas Beck 博士开发的髋关节结构分析程序和 Arun Karlamangla 博士开发的综合力量指数来测量髋关节几何形状和力量。我们还建议将区域 DXA 扫描获得的髋部结构参数和力量指数与使用定量计算机断层扫描 (QCT) 对女性子集进行 3 维成像获得的髋部结构参数和强度指数进行比较。我们研究的具体目标是： 1) 确定基于区域 DXA 的髋部几何形状和力量估计与 QCT 测量之间的相关性； 2) 确定基线时股骨颈尺寸、结构和综合强度指数的种族差异的方向和大小； 3) 确定股骨颈基线尺寸、结构和强度的预测因素； 4）确定不同种族的股骨颈尺寸以及结构和综合强度指标随年龄增长和绝经过渡的纵向变化率； 5）确定与股骨颈尺寸和强度指数纵向变化相关的因素，并将它们对尺寸和强度的影响与对骨密度的影响进行比较； 6) 检验基线股骨颈尺寸以及结构和综合强度指数可预测中年女性骨折风险的假设。我们的长期目标是大幅提高我们对衰老和更年期对多种族中年女性臀部尺寸、结构和力量测量的影响的理解。