Novel acquisition strategies for cardiovascular functional and molecular imaging

心血管功能和分子成像的新颖采集策略

基本信息

批准号：
7339685
负责人：
Youngho Seo
金额：
$ 15.6万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-01-15 至 2010-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7339685
关键词：
Age Anatomy Applications Grants Biomedical Engineering Calcium Cardiac Cardiovascular Diseases Cardiovascular system Cause of Death Characteristics Clinic Clinical Collimator Communities Condition Coronary Coronary Angiography Coronary Arteriosclerosis Data Detection Development Diagnosis EFRAC Equipment Evaluation Future Generations Goals Heart Image Imaging Techniques Infarction Isotopes Lead Maps Mechanics Methods Modality Morphologic artifacts Myocardial Myocardial perfusion Myocardium Noise Numbers Patient Care Management Patients Performance Perfusion Photons Positioning Attribute Protocols documentation Radionuclide Imaging Range Recovery Research Research Personnel Research Project Grants Resolution Rest Sampling Scanning Score Signal Transduction Societies Stratification Stress Stroke Volume System Techniques Technology Testing Time Time Study United States X-Ray Computed Tomography attenuation base cardiovascular imaging coronary artery calcification cost cost effectiveness improved molecular imaging novel outcome forecast programs research and development research study single photon emission computed tomography size tomography

项目摘要

DESCRIPTION (provided by applicant): Myocardial perfusion imaging with single photon emission tomography (SPECT) remains critically important for diagnosing and assessing coronary artery disease (CAD). The ability to differentiate normal myocardial regions from those that are ischemic or infarcted is essential for patient management and for determining patient prognosis. Currently, cardiac SPECT imaging requires at least two imaging sessions to obtain perfusion images under stress and under rest conditions, with each imaging session lasting 15 to 20 min. Furthermore, second generation SPECT/CT imagers now are available that can combine myocardial perfusion imaging with anatomical assessment of the heart with computed tomography; SPECT/CT therefore has the potential to provide a complete perfusion study combined with CT assessment of cardiac mechanics (ejection fraction, stroke volume, myocardial thickening), coronary patency, and status of coronary calcification in a single dual-modality imaging session. However, a combined SPECT/CT myocardial protocol would take up to 60 min, with virtually all of this time needed for SPECT, and would make poor utilization of this expen- sive equipment in the clinic and therefore may be cost prohibitive. Therefore, in this study the investigators propose to develop multipinhole SPECT imaging techniques with the goal of improving detection efficiency by 20-fold while maintaining or improving the spatial resolution in comparison to current SPECT imaging techniques. In addition, the investigators hypothesize that this method will allow simultaneous dual isotope imaging due to an improved signal to noise ratio of the multipinhole approach, which represents a further reduction in study time. The study encompasses the following specific aims: (1) We will develop and build a 20-pinhole collimator imaging system optimized for clinical myocardial perfusion imaging. (2) We will perform experiments to determine the minimal number of views of a multipinhole collimator sufficient to minimize angular sampling artifacts of the heart. We will obtain myocardial perfusion images of an anthropomorphic phantom with SPECT that are correlated with high-resolution anatomical images with CT and we will implement methods of correcting the SPECT image for attenuation using a priori structural information. (3) We will evaluate simultaneous dual-isotope imaging of myocardial perfusion with a multipinhole collimator. In this study, we will demonstrate that cross-talk correction of simultaneous 201TI/99mTc imaging can be improved significantly in the projection data acquired with a multipinhole collimator versus that obtained with a parallel hole collimator. Overall, successful development of multipinhole SPECT/CT promises to substantially increase the feasibility and cost-effectiveness of a comprehensive assessment of myocardial status and cardiac function in a way that will promote improved care and management of patients with coronary artery disease. '

描述（由申请人提供）：具有单光子发射断层扫描（SPECT）的心肌灌注成像对于诊断和评估冠状动脉疾病（CAD）至关重要。将正常心肌区域与缺血性或梗塞的能力区分开，对于患者管理和确定患者预后至关重要。当前，心脏SPECT成像需要至少两个成像会话才能在压力下和静止条件下获得灌注图像，每个成像疗程持续15至20分钟。此外，现在可以使用第二代SPECT/CT成像器，可以将心肌灌注成像与对心脏的解剖学评估与计算机断层扫描结合在一起；因此，SPECT/CT具有提供完整的灌注研究，并结合了心脏力学（射血分数，中风体积，心肌增厚），冠状动脉通畅和冠状动脉钙化状态的CT评估。但是，SPECT/CT心肌方案的组合最多可能需要60分钟，而SPECT几乎需要所有时间，并且会使该诊所中这种销售设备的利用率不佳，因此可能会持续不错。因此，在这项研究中，研究人员建议开发多孔SPECT成像技术，目的是通过与当前的SPECT成像技术相比，在维持或改善空间分辨率的同时，通过20倍提高检测效率。此外，研究人员假设该方法将允许同时进行双同位素成像，这是由于多个孔方法的信号与噪声比的提高，这代表了研究时间的进一步减少。该研究涵盖了以下特定目的：（1）我们将开发并建立一个针对临床心肌灌注成像进行优化的20孔准直仪成像系统。（2）我们将执行实验，以确定足以最大程度地减少心脏角度采样伪像的多孔准直仪的视图数量。我们将获得具有SPECT的拟人化幻影的心肌灌注图像，其与CT的高分辨率解剖图像相关，我们将实施使用先验结构信息校正SPECT图像以衰减的方法。（3）我们将使用多孔准直仪评估心肌灌注的双同位素成像。在这项研究中，我们将证明，在用多孔准直仪获得的投影数据中，可以显着改善同时对201TI/99MTC成像的串扰校正，而与平行孔直径获得的投影数据可以显着改善。总体而言，多孔SPECT/CT的成功发展有望大大提高对心肌状况和心脏功能的全面评估的可行性和成本效益，从而促进冠状动脉疾病患者的护理和管理。 '