Indiana University Bloomington (IUB) Center for Cannabis, Cannabinoids, and Addiction (C3A)

印第安纳大学伯明顿分校 (IUB) 大麻、大麻素和成瘾中心 (C3A)

基本信息

批准号：
10713089
负责人：
Kenneth Mackie
金额：
$ 167.47万
依托单位：
TRUSTEES OF INDIANA UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-15 至 2028-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10713089
关键词：
Address Affect Age Anatomy Applications Grants Behavioral Biological Biological Markers Brain Cannabinoids Cannabis Cell physiology Chronic Collaborations Creativeness Cultured Cells Data Data Storage and Retrieval Dopamine Drug Addiction Drug abuse Education Endocannabinoids Ensure Fostering Foundations Functional Imaging Funding Goals Grant Home Illinois Image Imaging Techniques In Vitro Indiana Individual Institution Intake Kentucky Knowledge Learning Letters Light Lipids Mass Spectrum Analysis Measures Mentors Microscopy Midwestern United States Modality Molecular Mus National Institute of Drug Abuse Neuromodulator Neurosciences Ohio Optics Paper Participant Pathway interactions Pattern Pharmaceutical Preparations Pilot Projects Plasma Population Predictive Factor Process Productivity Public Health Publishing Qualifying Recording of previous events Relapse Research Research Personnel Resources Running STEM career Sampling Scanning Scientist Serotonin Services Signal Transduction Slide Specimen Structure Substance Use Disorder Talents Techniques Technology Thinking Training Underrepresented Populations United States National Institutes of Health Universities West Virginia Withdrawal Work addiction awake career compulsion data dissemination equipment acquisition experience experimental study high resolution imaging imaging approach imaging modality in vivo in vivo calcium imaging innovation interest lipid mediator microscopic imaging multi-photon multimodality multiphoton imaging multiphoton microscopy nanoscale non-drug novel novel strategies operation optical imaging outreach phytocannabinoid preservation prevent programs reconstruction sensor superresolution microscopy tissue fixing underserved minority university student

Address Affect Age Anatomy Applications Grants Behavioral Biological Biological Markers Brain Cannabinoids Cannabis Cell physiology Chronic Collaborations Creativeness Cultured Cells Data Data Storage and Retrieval Dopamine Drug Addiction Drug abuse Education Endocannabinoids Ensure Fostering Foundations Functional Imaging Funding Goals Grant Home Illinois Image Imaging Techniques In Vitro Indiana Individual Institution Intake Kentucky Knowledge Learning Letters Light Lipids Mass Spectrum Analysis Measures Mentors Microscopy Midwestern United States Modality Molecular Mus National Institute of Drug Abuse Neuromodulator Neurosciences Ohio Optics Paper Participant Pathway interactions Pattern Pharmaceutical Preparations Pilot Projects Plasma Population Predictive Factor Process Productivity Public Health Publishing Qualifying Recording of previous events Relapse Research Research Personnel Resources Running STEM career Sampling Scanning Scientist Serotonin Services Signal Transduction Slide Specimen Structure Substance Use Disorder Talents Techniques Technology Thinking Training Underrepresented Populations United States National Institutes of Health Universities West Virginia Withdrawal Work addiction awake career compulsion data dissemination equipment acquisition experience experimental study high resolution imaging imaging approach imaging modality in vivo in vivo calcium imaging innovation interest lipid mediator microscopic imaging multi-photon multimodality multiphoton imaging multiphoton microscopy nanoscale non-drug novel novel strategies operation optical imaging outreach phytocannabinoid preservation prevent programs reconstruction sensor superresolution microscopy tissue fixing underserved minority university student

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项目摘要

Abstract We are proposing to establish the IU Bloomington Center for Cannabis, Cannabinoid, and Addiction (IUB-C3A) as a NIDA Core Center for Excellence to serve addiction researchers both in the central Midwest and across the nation. This Center will offer core services to further our understanding of fundamental brain processes leading to or following the use of addictive drugs, particularly cannabis. The IUB-C3A will consist of two service cores, a pilot project core, and an administrative core. The Administrative Core will provide a well- defined structure for efficient center management, for public outreach, for organizing the Center’s courses, as well as for preserving and making easily accessible the data generated by the Center’s scientists. The Bioactive Lipid Mediators Core (BLMC) will provide analytical service for detecting cannabinoids and other bioactive lipid mediators in biological samples and run a summer course directed towards underserved minority college students interested in STEM careers. The MultiScale Imaging Core (MSIC) will offer services and training across a range of light microscopic imaging modalities. The multiphoton resource of the MSIC will include training and access to longitudinal in vivo imaging of calcium and other sensors (e.g., neuromodulators such as endocannabinoids, dopamine, and serotonin) from very young ages as well as long-range pathway tracing in “cleared” brain specimens. The STORM/confocal resource of the MSIC will offer users the opportunity to perform correlative structure/function studies from the macro- to nanoscale level and will also offer courses on these techniques. Both cores will emphasize innovation and integration of their respective techniques, as outlined in the proposal. The Pilot Project Core will solicit pilot projects from C3A Affiliates and investigators outside of the drug abuse field and mentor them through the process of obtaining data and NIDA support for their research ideas. The PIs for the IUB-C3A have a long history of productive collaborations, including publishing more than sixty papers together and holding several MPI NIH grants. The IUB-C3A is conceptualized as a resource that will offer opportunities for other addiction investigators across the Central Midwest (Southern Illinois, Indiana, Kentucky, Ohio, and West Virginia), a region strongly affected by drug addiction, and across the nation. The IUB-C3A aims to increase diversity in addiction research through a combination of summer experiences and pilot project programs targeted to under-represented populations in neuroscience and addiction. A core goal of these programs is to bring talented individuals into the field of addiction research. We anticipate that they will apply creative directions, rigorous experimental approaches, and novel ways of thinking to a major public health problem. The strong support of Indiana University to this endeavor is evident by generous matching funds for both equipment purchases and our diversity programs. All of these factors predict that the IUB-C3A will become a regional and national resource for better understanding and developing treatments for addictive disorders and their consequences.

抽象的我们建议建立IU Bloomington大麻，大麻素和成瘾中心（IUB-C3A）作为NIDA核心卓越中心，为中西部和整个中部的成瘾研究人员服务国家。该中心将提供核心服务，以进一步了解我们对基本大脑过程的理解导致或之后使用添加剂，尤其是大麻。 IUB-C3A将包括两个服务核心，试点项目核心和行政核心。行政核心将提供一个很好的为有效的中心管理，公共宣传，组织中心课程的确定结构，作为以及在中心科学家生成的数据中保存和易于访问。生物活性脂质介质核心（BLMC）将提供分析服务，以检测大麻素和其他生物学样本中的生物活性脂质介质，并运行针对少数族裔的夏季课程对STEM职业感兴趣的大学生。多尺度成像核心（MSIC）将提供服务，并跨多种光显微成像方式的训练。 MSIC的多光子资源将包括训练并进入钙和其他传感器的纵向体内成像（例如，神经调节剂例如内源性大麻素，多巴胺和5-羟色胺），以及远程途径追踪“清除”的大脑标本。 MSIC的风暴/共聚焦资源将为用户提供从宏观到纳米级水平进行相关结构/功能研究的机会，也将提供有关这些技术的课程。两个核心都将强调各自的创新和整合该提案中概述的技术。试点项目核心将征求C3A分支机构的试点项目，滥用药物领域以外的调查人员，并通过获取数据和NIDA的过程进行指导支持他们的研究思想。 IUB-C3A的PI有悠久的产品合作历史，包括一起发表六十篇论文并持有多个MPI NIH赠款。 IUB-C3A是概念化为一种资源，将为中央的其他成瘾研究者提供机会中西部（伊利诺伊州南部，印第安纳州，肯塔基州，俄亥俄州和西弗吉尼亚州），该地区受毒品的强烈影响成瘾，以及全国。 IUB-C3A旨在通过A来增加成瘾研究的多样性夏季经验和试点项目计划的结合，针对代表性不足的人群神经科学和成瘾。这些计划的核心目标是将有才华的个人带入成瘾研究。我们预计他们将采用创造性的方向，严格的实验方法，以及新的思维方式来解决一个重大的公共卫生问题。印第安纳大学的强烈支持为了购买设备和我们的多样性计划，慷慨的匹配资金证明了努力。全部这些因素预测，IUB-C3A将成为更好理解的区域和国家资源并开发有关累加障碍及其后果的治疗方法。