Development of a Neurovascular Magnetic Particle Imaging system with sub-millimeter resolution and real time speed for non-radiative 3D perfusion angiography

开发具有亚毫米分辨率和实时速度的神经血管磁粒子成像系统，用于非辐射 3D 灌注血管造影

• 批准号: 9049379
• 负责人: Patrick Goodwill
• 金额: $ 22.38万
• 依托单位: MAGNETIC INSIGHT, INC.
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-15 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9049379
• 关键词: Acute; Amplifiers; Aneurysm; Angiography; Animals; Biological Sciences; Biomedical Engineering; Blood Vessels; Brain; Brain Injuries; Businesses; Caliber; Cardiovascular system; Centers for Disease Control and Prevention (U.S.); Cerebral perfusion pressure; Clinical; Computer software; Contracts; Development; Diagnosis; Diagnostic; Diagnostic Imaging; Discipline of Nuclear Medicine; Disease; Electrical Engineering; Electronics; Engineering; Equipment; Etiology; Evaluation; Fluoroscopy; Frequencies; Future; Goals; Grant; Health; Healthcare Systems; Human; Image; Imaging Techniques; Imaging technology; Industry; Iodine; Ionizing radiation; Iron; Kidney Diseases; Lead; Long-Term Care; Magnetic Resonance Imaging; Magnetism; Malignant Neoplasms; Measures; Mechanics; Mediation; Medical; Methods; Modality; Modeling; Monitor; Noise; Organ; Patients; Perfusion; Phase; Procedures; Protocols documentation; Radiation; Resistance; Resolution; Risk; Rotation; Safety; Sensitivity and Specificity; Signal Transduction; Small Business Innovation Research Grant; Speed; Staging; Stenosis; Stress Tests; Stroke; Stroke prevention; Structure; System; Techniques; Technology; Testing; Thallium Myocardial Perfusion Imaging Stress Test; Time; Tissues; Tracer; Ultrasonography; Vasospasm; Vendor; Venous Malformation; Weight-Bearing state; X-Ray Computed Tomography; acute stroke; animal imaging; cerebrovascular; cerebrovascular imaging; computer science; contrast imaging; cost; design; design and construction; imaging modality; imaging system; innovation; iron oxide; killings; magnetic field; malformation; member; millimeter; nanoparticle; new technology; particle; pre-clinical; prevent; professor; programs; prototype; reconstruction; response

 DESCRIPTION (provided by applicant): There is a clinical need for new neurovascular imaging techniques for the diagnosis, staging, and monitoring of acute stroke and sub-acute stenoses, arterial-venous malformations (AVMs), and aneurysms, among others. Together, these etiologies frequently manifest in acute stroke and kill over 130,000 people per year with an estimated cost the US healthcare system of over 36.5 billion dollars per year. A reliable and non-invasive neurovascular stress test, similar in concept to a cardiac stress test, would revolutionize cerebrovascular imaging and stroke prevention. It is well known that perfusion imaging, combined with a means of altering cerebral perfusion pressure or cerebrovascular resistance, can measure a patient's cerebrovascular reserve and predict the risk of stroke. Current neurovascular imaging techniques suffer from limitations in radiation exposure, safety, speed, sensitivity, and specificity that prevent their use in measuring cerebrovascular reserve. Magnetic particle imaging (MPI) is a new imaging technology that answers a clinical need for a safe, rapid 3D perfusion and 3D angiography technique without ionizing radiation or toxic tracers to image intracranial diseases such as stenosis (stroke), aneurysm, vasospasms and malformations. The MPI tracer is made with Iron Oxide (SPIO), significantly safer than Iodine (used in CT and fluoroscopy), and Gadolinum (used in MRI). The safe tracer and absence of harmful radiation leads to reduced long term medical costs for patient undergoing diagnostic angiography, and especially patients undergoing repeated diagnostic angiography procedures associated with long term care. MPI produces absolutely no signal from overlying tissues creating a positive contrast and quantitative angiography images or real time perfusion with unprecedented contrast to- noise and signal-to-noise. Successful completion of a human brain imager will mark the beginning of a new field of diagnostic imaging comparable in scope to the introduction of MRI, CT, or Ultrasound. This project aims to develop the first high resolution real time MPI system tailored for clinical cerebrovascular imaging. The proposed system will be the world's highest sensitivity and highest resolution tomographic MPI scanner. In Phase I of this SBIR, we will complete the main magnet design, build a 1/4 scale prototype, and develop our manufacturing plan. In Phase II we will construct the magnet and obtain phantom and animal images. In Phase III we will perform animal and then human testing

 描述（由申请人提供）：临床需要新的神经血管成像技术来诊断、分期和监测急性中风和亚急性狭窄、动静脉畸形（AVM）和动脉瘤等。这些病因经常表现为急性中风，每年导致超过 130,000 人死亡，估计美国医疗保健系统每年的费用超过 365 亿美元。无创神经血管压力测试在概念上与心脏压力测试类似，将彻底改变脑血管成像和中风预防众所周知，灌注成像与改变脑灌注压或脑血管阻力的方法相结合，可以测量患者的脑血管。目前的神经血管成像技术在辐射暴露、安全性、速度、灵敏度和特异性方面存在局限性，阻碍了其在测量脑血管储备中的应用。 (MPI) 是一种新型成像技术，可满足临床对安全、快速 3D 灌注和 3D 血管造影技术的需求，无需电离辐射或有毒示踪剂即可对狭窄（中风）、动脉瘤、血管痉挛和畸形等颅内疾病进行成像。由氧化铁 (SPIO) 制成，比碘（用于 CT 和透视）和钆（用于 MRI）安全得多。安全的示踪剂和无有害辐射可降低接受诊断性血管造影的患者的长期医疗成本，尤其是接受与长期护理相关的重复诊断性血管造影程序的患者，MPI 绝对不会产生来自上层组织的信号，从而产生阳性对比和定量血管造影。具有前所未有的噪声对比度和信噪比的图像或实时灌注将标志着诊断成像新领域的开始，其范围可与 MRI、CT 或超声波的引入相媲美。这该项目旨在开发第一个高分辨率真实 专为临床脑血管成像量身定制的 MPI 系统。该系统将是世界上灵敏度最高、分辨率最高的断层 MPI 扫描仪。在该 SBIR 的第一阶段，我们将完成主磁体设计，构建 1/4 比例原型并开发。我们的制造计划在第二阶段我们将建造磁铁并获得模型和动物图像在第三阶段我们将进行动物测试，然后进行人体测试。