Collaborative Approach for Asian Americans, Native Hawaiians, and Pacific Islanders Research and Education (CARE) 2.0

亚裔美国人、夏威夷原住民和太平洋岛民研究与教育 (CARE) 2.0 合作方法

• 批准号: 10740342
• 负责人: Joshua Grill
• 金额: $ 322.24万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10740342
• 关键词: Acceleration; Achievement; Adult; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Asian Americans; Asian Indian; Asian population; Attitude; Behavioral; Biological; Biological Markers; Blood; Budgets; Caregivers; Clinical Research; Clinical Trials; Communities; Data Analyses; Data Set; Databases; Education; Effectiveness; Elderly; Eligibility Determination; Enrollment; Ensure; Equity; Ethnic Origin; Filipino; Focus Groups; Funding; Hawaiian; Health; Heterogeneity; Image; Individual; Japanese; Koreans; Language; Learning; Life Style Modification; Lightning; Limited English Proficiency; Methods; Modality; Multilingualism; Native Hawaiian; Native Hawaiian or Other Pacific Islander; Outcome; Pacific Islander; Participant; Pattern; Persons; Population; Positioning Attribute; Procedures; R24; Recommendation; Registries; Reporting; Research; Research Design; Risk Factors; Samoan; Sampling; Source; Structure; Subgroup; Testing; Therapeutic; Underrepresented Populations; United States; United States National Institutes of Health; Vietnamese; caregiving; caregiving research; cohort; collaborative approach; comparative; dementia caregiving; dementia risk; effectiveness evaluation; experience; health disparity; improved; innovation; interest; outreach; prospective; racial population; recruit; recruitment science; retention rate; screening; secondary analysis; social culture; socioeconomics; tool; willingness

Project Summary/Abstract of CARE 2.0 Despite being the fastest growing racial population in the United States, Asian American, Native Hawaiian, and Pacific Islander (AANHPI) persons remain severely underrepresented in research. For example, less than 3% of participants in the National Alzheimer's Coordinating Center database are AANHPI individuals and even fewer are enrolled in clinical trials of promising therapeutics. The Collaborative Approach for Research and Education (CARE) registry (R24 AG063718) is a US multi-lingual registry built to improve AANHPI representation in Alzheimer’s disease and related dementias (ADRD), aging, and caregiving research. Launched in October 2020, CARE has enrolled 9,405 AANHPI adults (as of 10/2/22) including 55.9% with limited English proficiency and 80.9% with no prior research participation experience. CARE has referred more than >5,500 participants to 27 studies that are in various stages of recruitment and study completion. As a critical next step and guided by the NIA health disparities framework, we propose CARE 2.0 to strategically expand the registry, advance the science of recruitment and retention of AANHPI participants, and examine the factors associated with research enrollment decisions among referred registry participants. Our specific aims include: 1) Examine attitudes toward health research in a diverse cohort of 10,000 newly recruited AANHPI adults in the US; 2) Elicit perspectives and recommendations from CARE participants about registry retention, and develop, implement, and evaluate recommended registry retention strategies. The Lightning Report Method will be used to conduct dynamic qualitative data analysis and rapid synthesis of the findings to allow rapid comparative analyses across groups and contexts to derive targeted strategies that are sensitive to the diverse needs of retaining AANHPI participants; and 3) Optimize CARE registry participants’ inclusion in NIA- funded and other aging studies and examine factors including study- and participant-level factors associated with participation in research. These innovative aims will increase and test the value of the CARE registry and inform the field more broadly on how best to increase representation of AANHPI groups in research. CARE is well-positioned to complete these aims and contribute to the growing science of recruitment and retention. This proposed application is responsive to PAR-22-093 (Research on Current Topics in ADRD) and NOT-AG-21-033 (Notice of Special Interest: Health Disparities and AD).

项目摘要/护理摘要2.0 尽管是美国亚裔美国人增长最快的种族人口 夏威夷本地人和太平洋岛民（AANHPI）的人仍然严重代表人数不足 研究。例如，不到3％的国家阿尔茨海默氏症协调参与者 中心数据库是AANHPI个体，甚至更少参加 有希望的疗法。研究与教育的协作方法（CARE） 注册表（R24 AG063718）是美国多种语言注册表，旨在改善AANHPI代表 在阿尔茨海默氏病和相关痴呆症（ADRD），衰老和护理研究中。 Care于2020年10月启动，已招募9,405名AANHPI成年人（截至10/10） 55.9％的英语能力有限，没有先前的研究参与，为80.9％ 经验。护理已将超过5500名参与者转介到27个研究中 招聘和学习完成阶段。作为下一步的关键，并在NIA Health的指导下 差异框架，我们建议Care 2.0以战略性扩展注册表，推动 AANHPI参与者的招聘和保留科学，并检查这些因素 与参考注册表参与者之间的研究入学决策有关。我们的具体 目的包括：1）检查10,000名新的潜水员队列中的健康研究 在美国招募了Aanhpi成年人； 2）从护理中提出观点和建议 有关注册表保留，开发，实施和评估的参与者建议 注册表保留策略。闪电报告方法将用于进行动态 定性数据分析和发现的快速综合以允许快速比较分析 跨群体和环境，以获取对潜水员需求敏感的有针对性策略 保留Aanhpi参与者； 3）优化护理注册表参与者将其纳入NIA- 资助和其他衰老研究以及检查包括研究和参与者级的因素 与参与研究有关的因素。这些创新的目标将增加和测试 护理注册表的价值并更广泛地告知该领域如何最好地增加 AANHPI小组在研究中的代表。护理有充分的位置以完成这些目标 并为不断增长的招聘和保留科学做出贡献。该建议的申请是 响应PAR-22-093（ADRD中当前主题的研究）和NOT-AG-21-033（请注意 特别感兴趣：健康差异和广告）。