Auditory prediction and error evaluation in the speech of individuals who stutter

口吃者言语中的听觉预测和错误评估

• 批准号: 10584316
• 负责人: Ayoub Daliri
• 金额: $ 55.47万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-01 至 2027-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10584316
• 关键词: Acceleration; Achievement; Address; Adult; Adult Stuttering; Auditory; Auditory system; Behavior Therapy; Behavioral; Brain; Characteristics; Child; Clinical; Communication; Detection; Development; Etiology; Evaluation; Exposure to; Feedback; Foundations; Goals; Individual; Intervention; Left; Longevity; Methods; Mission; Monitor; Motor; Motor Cortex; Movement; Occupational; Outcome; Output; Personal Satisfaction; Population; Predisposition; Process; Production; Protocols documentation; Quality of life; Relapse; Research; Research Project Grants; Role; Signal Transduction; Speech; Speech Delay; Stuttering; Techniques; Testing; Transcranial magnetic stimulation; United States National Institutes of Health; Well in self; auditory feedback; cost; improved; individual variation; neural; neurobehavioral; neurophysiology; programs; response; sensory system; social; socioeconomics; speech accuracy; speech fluency disorder; theories; transcranial direct current stimulation

PROJECT SUMMARY / ABSTRACT Stuttering is a speech fluency disorder that negatively impacts the communicative abilities of 5–8% of children and 1% of adults. Stuttering also limits the individual’s academic-occupational achievement and social- psychological wellbeing. Unfortunately, existing stuttering treatments are associated with considerable individual variation in their outcomes, and in some cases, are entirely ineffective. Additionally, existing treatments require many sessions, and some are susceptible to as much as 70% relapse, leading to costly solutions with limited accessibility, especially for individuals from lower socioeconomic backgrounds. A major barrier to developing effective stuttering treatments is our incomplete understanding of the specific neural processes underlying the behavioral aspects of stuttering. There is a critical need to (1) identify the deficient neural processes underlying stuttering, (2) determine their functional contributions to breakdowns in speech fluency, and (3) develop neural and behavioral interventions that specifically target the deficient processes, and thus, promote fluency in individuals who stutter. Current speech theories posit that as the brain prepares speech movements, it uses its predictions to prepare the sensory systems for more efficient and accurate speech monitoring. These predictive sensorimotor processes and their interplay with error-detection processes are critical for fluent speech production. This project’s overall objective is to elucidate the role of predictive sensorimotor processes in the breakdowns of speech fluency in children and adults who stutter. We will address this question using behavioral and neurophysiological recordings combined with neurostimulation techniques. Our central hypothesis is that stuttering is associated with deficits in predictive sensorimotor processes, leading to inaccurate predictions. Aim 1 will evaluate the effects of exposure to auditory errors on predictive sensorimotor processes of individuals who stutter across the lifespan. Aim 2 will characterize the temporal alignment of prediction and auditory feedback by delaying auditory feedback or speech initiation. Aim 3 will determine the functional contributions of the speech premotor cortex in predictive sensorimotor processes. Overall, the expected outcome of this mechanistic research program is a detailed neuro-developmental account of deficits in predictive processes of stuttering individuals across the lifespan. This project’s results will have a critical positive impact because (1) they will form a robust scientific foundation for developing neural and behavioral interventions for stuttering, and (2) they will have significant implications for theories of stuttering and speech production.

项目摘要 /摘要 口吃是一种言语流利障碍，对5-8％的儿童的沟通能力产生负面影响 和1％的成年人。口吃还限制了个人的学术成就成就和社会 - 心理健康。不幸的是，现有的口吃治疗与考虑个人有关 其结果的变化，在某些情况下是完全无效的。此外，现有治疗需要 许多课程，有些会议容易受到70％的缓解，导致昂贵的解决方案有限 可访问性，特别是对于来自较低社会经济背景的个人。发展的主要障碍 有效的口吃治疗是我们对依据的特定神经源的不完全理解 口吃的行为方面。迫切需要（1）确定基本的神经过程不足 口吃，（2）确定其对语音流利分解的功能贡献，（3）发展神经元 以及专门针对默认过程的行为干预措施，从而促进流利程度 口吃的人。当前的语音理论海报，当大脑准备语音运动时，它使用了 预测，准备感觉系统以进行更有效，更准确的语音监视。这些预测性 感觉运动过程及其与错误检测过程的相互作用对于流利的语音至关重要 生产。该项目的总体目标是阐明预测性感觉运动过程的作用 口吃的儿童和成人的语音流利分解。我们将使用行为解决这个问题 和神经生理记录结合了神经刺激技术。我们的中心假设是 口吃与预测性感觉运动过程中的缺陷有关，导致预测不准确。目的 1将评估暴露于听觉错误对个人的预测感觉运动过程的影响 在整个生命周期中口吃。 AIM 2将表征预测和听觉反馈的暂时对齐 延迟听觉反馈或语音计划。 AIM 3将决定演讲的功能贡献 预测性感觉运动过程中的前皮层。总体而言，这种机械的预期结果 研究计划是口吃预测过程中缺陷的详细神经开发说明 整个生命周期的个人。该项目的结果将产生关键的积极影响，因为（1）它们将形成 为开发口吃的神经和行为干预措施的强大科学基础，（2）他们将 对口吃和语音生产的理论具有重要意义。