NIA/AA for Institute on Methods and Protocols for Advancement of Clinical Trials in ADRD (NIA/AA IMPACT-AD Course)

NIA/AA ADRD 临床试验推进方法和方案研究所（NIA/AA IMPACT-AD 课程）

• 批准号: 10410305
• 负责人: Joshua Grill
• 金额: $ 42.6万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10410305
• 关键词: Achievement; Active Learning; Address; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease therapy; Area; Award; Biological Markers; Biometry; Budgets; Caring; Characteristics; Clinical; Clinical Investigator; Clinical Trials; Communication; Communities; Continuing Education; Development; Diagnosis; Disabled Persons; Diverse Workforce; Education; Elements; Ensure; Ethics; Ethnic group; Evaluation; Evidence Based Medicine; Evolution; Faculty; Fellowship; Funding; Generations; Geriatrics; Goals; Grant; Hispanic-serving Institution; Historically Black Colleges and Universities; Individual; Informatics; Infrastructure; Institutes; Instruction; Interdisciplinary Study; Intervention; Knowledge; Lead; Learning; Long-Term Effects; Measures; Medical; Medical Research; Mentors; Mentorship; Methodology; Methods; Minority Groups; Mission; Modernization; Monitor; National Institute on Aging; Neuropsychology; Outcome Study; Participant; Patient Recruitments; Persons; Principal Investigator; Professional Organizations; Protocols documentation; Public Health; Race; Request for Proposals; Research; Research Personnel; Resources; Science; Scientist; Source; Structure; Training; Training Programs; United States National Institutes of Health; Woman; aging population; base; career; clinical care; cohort; design; disadvantaged background; education resources; experience; follow-up; improved; innovation; medical specialist; medical specialties; meetings; multidisciplinary; multimodality; neuropsychopharmacology; next generation; novel; outreach; programs; recruit; satisfaction; skills; sociodemographics; success; symposium; therapy development; trial design; virtual; workforce needs

Project Summary There is an urgent need for improved therapies for Alzheimer’s Disease and Related Dementias (ADRD). Critical to the mission to develop treatments for and curb the public health impact of ADRD will be a new generation of ADRD scientists, especially scientists with the unique training and skills necessary to design and perform clinical trials. This training is rarely provided through the traditional course of medical or biostatistical education. Moreover, to develop improved therapies for ADRD, multidisciplinary expertise in clinical trials will be necessary, including medical specialists but also expertise in biostatistics, biomarkers, trial design, participant recruitment, study organization, and trial ethics. This proposal requests support for a first-of-its-kind training program in the essential elements of design and conduct of ADRD trials that will leverage the full infrastructure and expertise of the Alzheimer’s Clinical Trials Consortium (ACTC) and be conducted annually to enable a diverse range of clinicians, scientists and researchers to receive modern and robust training on ADRD clinical trials.

项目摘要 迫切需要改善阿尔茨海默氏病和相关痴呆症（ADRD）的疗法。批判的 要为开发和遏制ADRD公共卫生影响的治疗和遏制的使命将是新一代 ADRD科学家，尤其是具有设计和执行临床所必需的独特培训和技能的科学家 试验。这种培训很少通过传统的医学或生物统计教育提供。 此外，为了开发改进的ADRD疗法，需要在临床试验中进行多学科专业知识， 包括医学专家，还包括生物统计学，生物标志物，试验设计，参与者招聘专家， 研究组织和试验伦理。该提案要求支持在 ADRD试验的设计和行为的基本要素，这些要素将利用完整的基础设施和专业知识 阿尔茨海默氏症的临床试验财团（ACTC）每年进行，以实现潜水员的范围 临床医生，科学家和研究人员接受ADRD临床试验的现代和强大的培训。