Training in Translational ADRD Neuroscience (TITAN)

转化 ADRD 神经科学培训 (TITAN)

• 批准号: 10475713
• 负责人: Joshua Grill
• 金额: $ 35.92万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10475713
• 关键词: Alzheimer' s disease related dementia; Neurosciences; Training

Project Summary/Abstract Population aging is leading to a public health crisis in the growing number of people affected by Alzheimer’s disease (AD) and Related Dementias (ADRD). It has been more than 15 years since the last FDA approval for a new treatment for ADRD. To continue the dramatic progress over the last decade in understanding ADRD pathophysiology we will require significant preclinical and clinical translational research to bring candidate therapies to clinical use and grow a therapeutic armamentarium sufficient to curb the public health impact of ADRD. Essential to this success will be a new generation of ADRD scientists, especially scientists with the unique training and skills necessary to design and perform translational research. This training is rarely provided through the traditional course of medical, clinical psychology, basic science, or biostatistical education. As a result, there is a dearth of well-trained ADRD translational investigators. Moreover, there is inadequate diversity among the current group of active ADRD translational investigators, limiting the unique perspectives and team science synergies that could propel the field toward critical solutions. We propose here a new training program in translational ADRD research titled “Training in Translational ADRD Neuroscience (TITAN)” at the University of California, Irvine (UCI). This new training program will be broadly inclusive of promising graduate students and junior translational scientists, such as medical doctors, clinical psychologists, epidemiologists, biostatisticians, bioethicists, and neuroscientists. We have assembled an outstanding and similarly diverse team of preceptors who will ensure the success of this new training program. The program will develop novel training opportunities in ADRD translational research while also leveraging the considerable scientific and training resources at UCI, including the NIA P30-funded Alzheimer’s Disease Research Center (ADRC), which since April 2020 includes a Research Education Component with complementary objectives. Similarly, the UCI Institute for Clinical and Translational Science (ICTS) is UCI’s NCATS-funded CTSA program that offers synergistic training options to be leveraged, such as the K-club, responsible conduct of research workshops, and KL2 funding mechanisms. We will recruit diverse trainees from multidisciplinary specialties as well as individuals from nationally underrepresented racial and ethnic groups, individuals with disabilities, individuals from disadvantaged backgrounds, and women.

项目摘要/摘要 人口衰老导致了越来越多的阿尔茨海默氏症人数的公共卫生危机 疾病（AD）和相关痴呆症（ADRD）。自上次FDA批准以来已经超过15年了 ADRD的新疗法。在过去的十年中，在理解ADRD的过去十年中取得了巨大的进步 病理生理学，我们将需要大量的临床前和临床翻译研究以携带候选者 治疗临床使用和种植足以遏制公共卫生影响的治疗性武术的疗法 adrd。这一成功至关重要的将是新一代的ADRD科学家，特别是 设计和执行转化研究所需的独特培训和技能。此培训很少提供 通过传统的医学，临床心理学，基础科学或生物统计教育的过程。作为 结果，训练有素的ADRD翻译研究人员死亡。而且，多样性不足 在目前的一组活跃的ADRD转化调查员中，限制了独特的观点和团队 科学协同作用可以推动该领域朝着关键解决方案迈进。 我们在这里提出了一项新的翻译ADRD研究培训计划，标题为“翻译ADRD培训 加利福尼亚大学尔湾分校（UCI）的神经科学（泰坦）。 包括应许的研究生和初中翻译科学家，例如医生，临床 心理学家，流行病学家，生物阶级主义者，生物伦理学家和神经科学家。我们已经组装了 杰出的和类似的主体团队将确保这项新培训计划的成功。 该计划将在ADRD转化研究中开发新的培训机会，同时还利用 UCI的大量科学和培训资源，包括NIA P30资助的阿尔茨海默氏病 研究中心（ADRC），自2020年4月以来，其中包括一个研究教育部分 补充目标。同样，UCI临床与转化科学研究所（ICT）是UCI的 NCATS资助的CTSA计划提供了可以利用的协同培训选项，例如K-Club， 负责任的研究研讨会和KL2资助机制。我们将从 多学科专业以及来自国家代表性不足的种族和种族的个人， 残疾人，来自不利背景的个人和妇女。