Training the Next Generation of Innovative and Collaborative Patient-Oriented Researchers to Reduce Obesity and Improve Cardiometabolic Health

培训下一代创新和协作的以患者为中心的研究人员，以减少肥胖并改善心脏代谢健康

• 批准号: 10721553
• 负责人: VICTORIA A CATENACCI
• 金额: $ 12.61万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-10 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10721553
• 关键词: Acceleration; Achievement; Address; Adult; Advisory Committees; Ancillary Study; Atrial Fibrillation; Award; Behavior; Behavior Therapy; Behavioral; Biological; Blood Pressure; Body Weight decreased; Body mass index; Caloric Restriction; Cardiometabolic Disease; Cardiovascular Diseases; Career Mobility; Chronic Disease; Clinical; Clinical Investigator; Collaborations; Complex; Conduct Clinical Trials; Coronary Arteriosclerosis; Data; Dedications; Development; Diet; Doctor of Philosophy; Eating; Energy Intake; Energy Metabolism; Ensure; Epidemic; Evidence based intervention; Exercise; Faculty; Food; Funding; Glycosylated hemoglobin A; Goals; Grant; Health; Heart failure; High Density Lipoprotein Cholesterol; Individual; Infrastructure; Institution; Interdisciplinary Study; Intermittent fasting; Intervention; Intervention Trial; K-Series Research Career Programs; Knowledge; Leadership; Life Style; Maintenance; Measures; Medical Students; Medicine; Mentors; Mentorship; Methodology; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Morbid Obesity; Obesity; Participant; Patient Education; Pattern; Persons; Physical activity; Physicians; Physiology; Positioning Attribute; Postdoctoral Fellow; Prediction of Response to Therapy; Prevalence; Productivity; Public Health; Publications; Recording of previous events; Research; Research Personnel; Research Training; Resources; Risk; Risk Factors; Risk Reduction; Role; Scientist; Sleep; Sleep Deprivation; Time; Training; Training Programs; Translating; Triglycerides; Unhealthy Diet; United States National Institutes of Health; Weight; Weight maintenance regimen; cardiometabolism; cardiovascular disorder risk; career; circadian; clinical training; design; disorder risk; effective intervention; evidence base; experience; graduate student; improved; innovation; interdisciplinary collaboration; interest; lifestyle intervention; next generation; novel; nutrition; obesity development; obesity treatment; patient oriented; patient oriented research; programs; psychosocial; response; secondary analysis; skill acquisition; skills; success; training opportunity; treatment research; treatment response; trial design; undergraduate student; weight loss intervention; weight loss program; weight maintenance

PROJECT SUMMARY/ABSTRACT My career focuses on research, clinical, and translational efforts to improve lifestyle treatment for obesity. Obesity is a major contributor to cardiovascular disease (CVD), accelerated by the current epidemic of highly palatable energy dense food, reduced physical activity, and insufficient sleep. While weight loss can reduce CVDrisk, sustaining weight loss is a major challenge for most individuals with obesity. It is imperative to identify innovative and evidence-based strategies to promote greater and more durable weight loss. My collaborative research program focuses on understanding predictors of successful weight loss maintenance and translating those findings into strategies to improve lifestyle weight management programs. Specifically, I develop and evaluate novel weight loss interventions, focusing on alterations of the timing or pattern of energy intake and physical activity (PA). My studies involve rigorous, objective measures of free-living energy expenditure and energy intake, and multi-disciplinary collaborations to comprehensively assess potential biologic, behavioral, psychosocial, and environmental predictors of treatment response. Collectively, these studies provide a framework and wealth of data for trainees to perform hypothesis-driven patient-oriented research (POR). I am deeply committed to mentoring the next generation of innovative, collaborative clinical researchers to reduce obesity and cardiometabolic disease risk. I have 8 years of mentoring experience supporting new and early- stage clinical investigators in POR (undergraduate, graduate, and medical students; MD and PhD post-doctoral research fellows; and junior faculty). My mentees have an excellent record of publication productivity, NIH grant funding, successful career transitions, and retention in academic medicine. The K24 Mid-Career Investigator Award will provide dedicated time for me to deliver focused mentorship to junior clinical investigators of exceptional potential and capitalize on the outstanding mentoring, research, and training resources of our campus. I will pursue leadership and administrative training, as well as develop multidisciplinary collaborations to enhance my knowledge and skills in sleep/circadian physiology and qualitative methodology to extend the breadth and reach of my obesity treatment POR program. I have assembled an experienced team of senior clinical researchers with extensive mentorship experience and leadership roles in clinical and research training programs on campus to serve as a K24 Advisory Committee to guide me during the K24 award period. My specific aims are to 1) Mentor junior clinical investigators to create a pipeline of well-trained patient-oriented researchers focused on obesity, nutrition, PA, and sleep, and 2) Build and enhance my collaborative research program designed to rigorously evaluate strategies involving alterations of the timing or pattern of behaviors (diet, PA, and sleep) to develop more effective lifestyle interventions to treat obesity, reduce cardiometabolic disease, and improve health. As a dedicated physician-scientist, I am well-positioned to enhance the quality and breadth of POR in weight management and CVD risk reduction and become a national leader in this field.

项目概要/摘要 我的职业生涯专注于改善肥胖生活方式治疗的研究、临床和转化工作。 肥胖是心血管疾病的主要原因 疾病 （化学气相沉积）， 当前疫情的高发加速了 美味的能量密集食物，体力活动减少，睡眠不足。虽然减肥可以减少 CVD风险，持续减肥是大多数肥胖症患者面临的主要挑战。必须要认清 创新和基于证据的策略，以促进更大和更持久的减肥。我的协作 研究计划的重点是了解成功维持减肥的预测因素并将其转化为 这些发现转化为改善生活方式的体重管理计划的策略。具体来说，我开发并 评估新的减肥干预措施，重点关注能量摄入时间或模式的改变，以及 体力活动（PA）。我的研究涉及对自由生活的能量消耗进行严格、客观的测量 能量摄入和多学科合作，全面评估潜在的生物、行为、 治疗反应的社会心理和环境预测因素。总的来说，这些研究提供了 为学员提供以假设驱动、以患者为导向的研究 (POR) 的框架和丰富的数据。我是 坚定致力于指导下一代创新、协作的临床研究人员，以减少 肥胖和心脏代谢疾病的风险。我有 8 年的指导经验，支持新人和早期- POR 阶段的临床研究者（本科生、研究生和医学生；医学博士和博士后 研究员；和初级教师）。我的学员在发表生产力方面拥有出色的记录，并获得美国国立卫生研究院 (NIH) 资助 资金、成功的职业转型以及学术医学的保留。 K24 职业生涯中期调查员 该奖项将为我提供专门的时间为初级临床研究人员提供集中指导 卓越的潜力并利用我们杰出的指导、研究和培训资源 校园。我将寻求领导力和行政培训，并发展多学科合作 增强我在睡眠/昼夜节律生理学和定性方法方面的知识和技能，以扩展 我的肥胖治疗 POR 计划的广度和范围。我组建了一支经验丰富的资深团队 临床研究人员在临床和研究培训方面具有丰富的指导经验和领导作用 作为 K24 顾问委员会，在 K24 奖励期间为我提供指导。我的 具体目标是 1) 指导初级临床研究人员创建训练有素、以患者为导向的管道 研究人员专注于肥胖、营养、体能活动和睡眠，2) 建立并加强我的合作研究 旨在严格评估涉及改变行为时间或模式的策略的计划 （饮食、体能活动和睡眠）开发更有效的生活方式干预措施来治疗肥胖、减少心脏代谢 疾病，并改善健康。作为一名敬业的医师科学家，我有能力提高质量和 POR 在体重管理和降低 CVD 风险方面的广泛应用，并成为该领域的全国领先者。