Training in the Multiscale and Multimodal Analysis of Biomarkers in Alzheimer’s Disease

阿尔茨海默病生物标志物的多尺度和多模式分析培训

• 批准号: 10628648
• 负责人: ARTHUR W TOGA
• 金额: $ 17.53万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628648
• 关键词: Alzheimer' s Disease; Biological Markers; Training; multimodality

PROJECT SUMMARY/ABSTRACT Recognizing the critical need for a broad range of expertise in biomarker analysis at several levels of analysis, we propose a unique postdoctoral training program titled “Training for the Multiscale and Multimodal Analysis of Biomarkers in Alzheimer’s Disease” (AD). USC is home to leading experts who utilize biomarkers in their work investigating AD through a myriad of methods and analyses. Drawing from USC’s eminent resources and expertise, this proposal will focus on preparing investigators for independent research careers in the multiscale and multimodal analysis of biomarkers in AD, by integrating molecular and cellular methods, imaging tools and informatics, quantitative methods for clinical trials research, and large-scale population analyses. Our proposed training program draws preceptors and faculty from 12 schools, departments, institutes, and centers at USC, fulfilling these methodological areas of expertise: USC Mark and Mary Stevens Neuroimaging and Informatics Institute (INI) in the Keck School of Medicine (KSoM); Zilkha Neurogenetic Institute (ZNI) in the KSoM; Department of Neurology in the KSoM; Department of Neurological Surgery in the KSoM; Department of Radiology in KSoM; Alzheimer's Therapeutic Research Institute in the KSoM; Department of Population and Public Health Sciences at the KSoM; Department of Economics in the Dana and David Dornsife College of Letters, Arts and Sciences; Center for Economic and Social Research in the Dana and David Dornsife College of Letters, Arts and Sciences; Institute for Technology and Medical Systems Innovation (ITEMS), a joint initiative between Keck School of Medicine and Viterbi School of Engineering; Leonard D. Schaeffer Center for Health Policy and Economics, a unique collaboration between the USC Sol Price School of Public Policy and School of Pharmacy; and Leonard Davis School of Gerontology. Trainees will complete coursework, lab rotations, and career development activities, such as seminar series, instruction for problem solving, communication, time management, and leadership skills, and instruction and training in grant writing. Trainees will become conversant in all thematic areas and will be able to effectively collaborate outside of their own particular area of expertise. Specifically, the USC Training for the Multiscale and Multimodal Analysis of Biomarkers in AD will aim to: equip trainees with a combination of skills to conduct multiscale and multimodal analyses of biomarkers in AD by providing tailored, didactic research education opportunities to further the research potential of trainees; facilitate eminent research in the multiscale and multimodal analysis of biomarkers in AD by trainees, including the development of research ideas, execution of research projects, and dissemination of research findings; establish among trainees a collaborative and multidisciplinary team approach to advance research in the multiscale and multimodal analysis of biomarkers in AD; and successfully transition trainees to independent research careers, including securing their own research funding.

项目概要/摘要 认识到在多个分析层面上对生物标志物分析的广泛专业知识的迫切需求， 我们提出了一个独特的博士后培训计划，名为“多尺度和多模态分析培训” 阿尔茨海默病的生物标志物”(AD) 是在工作中使用生物标志物的领先专家的所在地。 AD 通过多种方法和分析进行调查，利用南加州大学的优质资源和分析。 专业知识，该提案将侧重于为研究人员在多尺度的独立研究生涯中做好准备 通过整合分子和细胞方法、成像工具和技术，对 AD 生物标志物进行多模式分析 我们提出的信息学、临床试验研究的定量方法和大规模人群分析。 培训计划吸引了来自南加州大学 12 个学院、系、研究所和中心的导师和教员， 满足这些方法论领域的专业知识：南加州大学马克和玛丽史蒂文斯神经影像和信息学 凯克医学院 (KSoM) 研究所 (INI)；KSoM 的 Zilkha 神经遗传学研究所 (ZNI)； KSoM 神经内科；KSoM 神经外科； KSoM 放射学；人口与医学系阿尔茨海默病治疗研究所； 达纳和大卫多恩西夫学院 KSoM 经济系公共卫生科学； 达纳和大卫·多恩西夫学院文学、艺术和科学经济和社会研究中心 文学、艺术和科学学院；技术和医疗系统创新研究所 (ITEMS)，一项联合倡议 凯克医学院和维特比工程学院之间；Leonard D. Schaeffer 健康中心 政策与经济学，南加州大学索尔·普莱斯公共政策学院和南加州大学公共政策学院之间的独特合作 药学、伦纳德·戴维斯老年学学院的学员将完成课程作业、实验室轮换和培训。 职业发展活动，例如研讨会系列、解决问题的指导、沟通、时间 管理、领导技能以及资助写作方面的指导和培训。 在所有主题领域，并将能够在自己的特定专业领域之外进行有效的合作。 具体来说，南加州大学 AD 生物标志物多尺度和多模式分析培训的目标是： 受训者具有对 AD 生物标志物进行多尺度和多模式分析的综合技能 提供量身定制的教学研究教育机会，以进一步发挥学员的研究潜力； 受训人员对 AD 生物标志物进行多尺度和多模式分析的杰出研究，包括 发展研究想法、执行研究项目和传播研究成果； 在学员中采用协作和多学科团队方法来推进多尺度和 AD 生物标志物的多模式分析；并成功地将学员过渡到独立研究职业， 包括确保自己的研究经费。

项目成果

Brain structural correlates of insomnia severity in 1053 individuals with major depressive disorder: results from the ENIGMA MDD Working Group.

• DOI: 10.1038/s41398-020-01109-5
• 发表时间: 2020-12-08
• 期刊: Translational psychiatry
• 影响因子: 6.8
• 作者: Leerssen J;Blanken TF;Pozzi E;Jahanshad N;Aftanas L;Andreassen OA;Baune BT;Brack I;Carballedo A;Ching CRK;Dannlowski U;Dohm K;Enneking V;Filimonova E;Fingas SM;Frodl T;Godlewska BR;Goltermann J;Gotlib IH;Grotegerd D;Gruber O;Harris MA;Hatton SN;Hawkins E;Hickie IB;Jaworska N;Kircher T;Krug A;Lagopoulos J;Lemke H;Li M;MacMaster FP;McIntosh AM;McLellan Q;Meinert S;Mwangi B;Nenadić I;Osipov E;Portella MJ;Redlich R;Repple J;Sacchet MD;Sämann PG;Simulionyte E;Soares JC;Walter M;Watanabe N;Whalley HC;Yüksel D;Veltman DJ;Thompson PM;Schmaal L;Van Someren EJW
• 通讯作者: Van Someren EJW