Data Management and Statistical Core (DMS)

数据管理和统计核心 (DMS)

基本信息

批准号：
10655666
负责人：
ARTHUR W TOGA
金额：
$ 31.57万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-01 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10655666
关键词：
Alzheimer disease prevention Alzheimer&apos s Disease Alzheimer’s disease biomarker Apolipoprotein E Biological Markers Biometry Blood Brain Clinical Clinical Research Clinical Trials Collection Communities Consultations Data Data Analyses Data Collection Database Management Systems Databases Dementia Development Diagnosis Down Syndrome Enrollment Ensure Environment Etiology Evaluation Faculty Frontotemporal Dementia Frontotemporal Lobar Degenerations Funding Genetic Genotype Image Image Analysis Informatics Information Systems Infrastructure International Leadership Link Longitudinal Studies Manuscripts Measures Methodology Mission Nature Participant Pathogenesis Phenotype Preparation Preventive Medicine Qualifying Research Research Design Research Personnel Resource Informatics Resources Sampling Scientist Services Standardization Statistical Data Interpretation Statistical Models System Tauopathies Tissue Sample Training and Education complex data computing resources data archive data dissemination data management design education research experience genome wide association study image archival system informatics tool large scale data longitudinal design multidimensional data multimodal data multimodality neuroimaging neuropathology statistics success web platform

项目摘要

Abstract: Data Core The Data Management and Statistical Core will provide informatics and statistics support for ADRC related dementia related research. The multimodal nature of data collected to investigate the etiology, pathogenesis, diagnosis, treatment, and prevention of AD requires robust informatics, data management and statistical approaches. Specifically, we will provide for: standardized collection of local assessments, scales and enrollment status, de-identifying, storing and tracking neuroimaging data, web-based systems for the databasing, protection, tracking and access of all data to qualified and authenticated scientists. We will ensure timely and accurate data entry to NACC related UDS and neuropathology databases and provide biostatistical consulting to ADRC investigators in the design, coordination and analysis of ADRC-related projects, including development projects. We will establish connections and coordinate with both local and national efforts to share and exchange well curated and comprehensively described data. Finally, we will provide education and training in design, statistical models and informatics in coordination with the ORE core. Existing strengths of our Core include data management and biostatistical resources embedded within the USC Mark and Mary Stevens Neuroimaging and Informatics Institute (INI) and the Department of Preventative Medicine. We have strong leadership by investigators involved in many of the national and global AD research related efforts and possess the resources necessary to insure success in our core.

摘要：数据核心数据管理和统计核心将提供信息学和统计支持用于 ADRC 相关痴呆症相关研究。收集数据的多模式性质研究AD的病因、发病机制、诊断、治疗和预防需要强有力的信息学、数据管理和统计方法。具体来说，我们将规定：本地评估、量表和入学状态的标准化收集、去识别化、存储和跟踪神经影像数据，基于网络的系统用于数据库、保护、跟踪和合格且经过认证的科学家可以访问所有数据。我们将确保及时、准确将数据输入 NACC 相关 UDS 和神经病理学数据库并提供生物统计为 ADRC 研究人员提供 ADRC 相关设计、协调和分析方面的咨询项目，包括开发项目。我们将与地方和国家建立联系并协调努力，以分享并交换精心策划和全面描述的数据。最后，我们将提供与 ORE 协调进行设计、统计模型和信息学方面的教育和培训核。我们核心的现有优势包括数据管理和生物统计资源嵌入南加州大学马克和玛丽史蒂文斯神经影像和信息学研究所 (INI) 和预防医学系。我们有调查人员的强有力的领导参与许多国家和全球AD研究相关工作并拥有资源确保我们的核心成功所必需的。