HABS-HD - Core B - Neuroimaging & Informatics Core

HABS-HD - 核心 B - 神经影像

• 批准号: 10493846
• 负责人: ARTHUR W TOGA
• 金额: $ 192.86万
• 依托单位: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-30 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10493846
• 关键词: Alzheimer' s Disease; Amyloid; Archives; Atherosclerosis; Biological Markers; Biostatistics Core; Blood Vessels; Brain; Cerebrovascular Circulation; Clinical; Clinical Data; Collaborations; Collection; Communities; Computers; Custom; Data; Data Analyses; Data Collection; Databases; Diffusion Magnetic Resonance Imaging; Documentation; Ensure; Environment; Ethnic group; Generations; Genetic; Goals; Health; Health Sciences; Hippocampus (Brain); Image; Informatics; Information Systems; Infrastructure; Institutes; Laboratories; Leadership; Liquid substance; MRI Scans; Magnetic Resonance Imaging; Measures; Methods; Nerve Degeneration; Neuropsychology; Noise; Parkinson Disease; Participant; Patients; Phase; Policies; Population; Positron-Emission Tomography; Process; Protocols documentation; Publications; Quality Control; Research; Research Personnel; Resolution; Risk; Role; Scanning; Schedule; Scientist; Services; Site; Slice; Support System; Texas; Translational Research; Universities; White Matter Hyperintensity; Work; aging brain; data acquisition; data analysis pipeline; data dissemination; data management; electronic data; electronic data capture system; experience; health application; health disparity; imaging facilities; imaging informatics; imaging modality; improved; multi-site trial; multimodality; neuroimaging; open data; programs; progression marker; racial and ethnic; tau Proteins; tool; user-friendly; web site

HABS-HD Neuroimaging & Informatics Core (Core B) Abstract The Neuroimaging & Informatics Core (Core B) is responsible for all neuroimaging acquisition protocols, storage protocols, QA/QC protocols, processing pipelines, and long-term storage of raw scans for the Health and Aging Brain Study- Health Disparities (HABS-HD) U19. The overall objective of Core B is to provide high quality imaging and summary data for Projects 1, 2, and 3 and for all U19 investigators. Core B is led by Dr. Arthur Toga (USC/LONI) and Co-Led by Dr. Meredith Braskie (USC/LONI/IGC). Images obtained as part of HABS-HD are stored and managed within the Laboratory of Neuro Imaging (LONI). At initiation of the HABS- HD U19, approximately 5,000 MRI scans and 6,000 PET scans will have been collected, stored and processed. HABS-HD magnetic resonance imaging (MRI) and amyloid positron emission tomography (PET) acquisition largely aligns to standard ADNI3 protocols. Selected imaging modalities will be processed by Core B and summary data will be uploaded to the HABS-HD database at 6-month intervals. All raw scans will also be available. Core B will provide the amyloid (A), tau (T), neurodegeneration (N), for the AT(N) framework that will be leveraged by Projects 1, 2 and 3, and will also provide summary vascular imaging data to be used by Project 2. All neuroimaging for the HABS-HD program occurs at the University of North Texas Health Science Center Institute for Translational Research (UNTHSC ITR) Imaging Center using the same MRI and PET scanners. Core strengths include decades of experience developing and managing multisite, large data projects. Under the leadership of Drs. Toga and Braskie and using the infrastructure of the USC Institute for Neuroimaging and Informatics (INI), LONI and ATRI, we will provide multi-site data management and dissemination of imaging and clinical data in a manner consistent with systems supporting the Alzheimer Disease Neuroimaging Initiative (ADNI), Global Alzheimer’s Association Interactive Network (GAAIN), Parkinson Progression Marker Initiative (PPMI), and others. All Core B activities will support the U19 scientific goals and the broader national AD and dementia research community. This first-ever comprehensive multimodal study of AD risk using the AT(N) framework within the three largest racial/ethnic groups in the U.S. (75% of the population) requires robust informatics, data management, and harmonization. Core B Aims are as follows: Aim 1: To create an imaging and informatics data management framework for all U19 Projects. Aim 2: To ensure high quality control of all neuroimaging data. Aim 3: To deliver a harmonized analysis workflow for each imaging modality that can accommodate any computational environment.

HABS-HD 神经影像与信息学核心（核心 B）摘要 神经影像和信息学核心（核心 B）负责所有神经影像采集协议， 存储协议、QA/QC 协议、处理流程以及健康原始扫描的长期存储 和衰老大脑研究 - 健康差异 (HABS-HD) U19 核心 B 的总体目标是提供高水平。 项目 1、2 和 3 以及所有 U19 Core B 研究人员的高质量成像和汇总数据由 Dr. Arthur Toga（南加州大学/洛尼分校）和 Meredith Braskie 博士（南加州大学/洛尼分校/IGC）共同领导 图片作为项目的一部分获得。 HABS-HD 在 HABS-启动时在神经影像实验室 (LONI) 内存储和管理。 HD U19 将收集、存储和处理大约 5,000 个 MRI 扫描和 6,000 个 PET 扫描。 HABS-HD 磁共振成像 (MRI) 和淀粉样蛋白正电子发射断层扫描 (PET) 采集 很大程度上符合标准 ADNI3 协议，选定的成像模式将由 Core B 和 摘要数据将每隔 6 个月上传到 HABS-HD 数据库，所有原始扫描也将被上传。 核心 B 将为 AT(N) 框架提供淀粉样蛋白 (A)、tau (T)、神经变性 (N)。 将被项目 1、2 和 3 利用，还将提供供以下人员使用的总结血管成像数据 项目 2. HABS-HD 项目的所有神经影像学均在北德克萨斯大学健康科学分校进行 转化研究中心 (UNTHSC ITR) 成像中心使用相同的 MRI 和 PET 核心优势包括数十年开发和管理多站点大数据的经验。 在 Toga 和 Braskie 博士的领导下，并利用南加州大学研究所的基础设施。 神经影像和信息学（INI）、LONI和ATRI，我们将提供多站点数据管理和 以与支持阿尔茨海默病的系统一致的方式传播影像和临床数据 疾病神经影像倡议 (ADNI)、全球阿尔茨海默病协会互动网络 (GAAIN)、 帕金森进展标记计划 (PPMI) 和其他所有核心 B 活动将支持 U19 科学。 目标和更广泛的国家 AD 和痴呆症研究界。 使用 AT(N) 框架对美国三大种族/族裔群体（75% 的人）进行 AD 风险研究 人口）需要强大的信息学、数据管理和协调性 核心 B 目标如下： 目标。 1：为所有 U19 项目创建成像和信息学数据管理框架 目标 2：确保。 目标 3：为每个成像提供统一的分析工作流程。 可以适应任何计算环境的模式。