Imaging Core

成像核心

基本信息

批准号：
10655670
负责人：
ARTHUR W TOGA
金额：
$ 34.16万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-01 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10655670
关键词：
Alzheimer&apos s Disease Alzheimer&apos s disease diagnosis Authorization documentation Biomedical Engineering Blood Vessels Cerebrovascular system Collaborations Communities Data Data Collection Dementia Development Early Diagnosis Family Practice Functional Imaging Functional disorder Genomics Gerontology Goals Grain Human Hybrids Image Imaging Device Imaging Techniques Impaired cognition MRI Scans Magnetic Resonance Imaging Medicine Metabolic Mission Modernization Neurology Neurosciences Noise Pathogenesis Pharmacology Physical therapy Physics Physiologic pulse Positron-Emission Tomography Postdoctoral Fellow Protocols documentation Psychology Quality Control Research Research Design Research Personnel Resources Risk Factors Risk Reduction Role Scanning Signal Transduction Standardization Training Training and Education Vascular Cognitive Impairment Vascular Diseases analytical tool authority cohort connectome contrast enhanced data dissemination data management data quality graduate student image archival system imaging facilities neuroimaging neurovascular novel open data protocol development recruit research study statistics structural imaging training opportunity vascular contributions vascular risk factor vector

项目摘要

PROJECT ABSTRACT As a part of the USC Alzheimer Disease Research Center competitive renewal, the Imaging Core will continue to serve the overall mission to provide high-quality MR and PET imaging resources to the local and broader AD research community. The ADRC Imaging Core will provide core resources, including MR physics and PET expertise, multi-scanner sequence and protocol development, image data quality control and management, research collaboration, and a global framework for conducting AD neuroimaging research. The Imaging Core is led by a well-integrated and collaborative team, including Arthur Toga (Core Leader), Judy Pa (Core Co-Leader), Meredith Braskie, Danny JJ Wang, Nasim Sheikh-Bahaei, and Paul Thompson, who together provide expertise in vascular, functional, and structural imaging and its analyses for 3T and 7T MRI, and PET. We propose 5 specific aims that provide an imaging framework for all ADRC projects; perform high quality control of all imaging data; develop technical and scientific approaches for ultra- high field 7T MRI; assist in PET protocol development and quality control; and conduct education and training in modern imaging techniques. Taken together, these goals will serve the USC ADRC’s unifying scientific theme of vascular contributions to Alzheimer disease: risk factors, neurovascular and metabolic mechanisms, and risk reduction.

项目摘要作为南加州大学阿尔茨海默病研究中心竞争性更新的一部分，成像核心将继续服务于为广大人民群众提供优质MR和PET影像资源的总体使命 ADRC 成像核心将提供本地和更广泛的 AD 研究社区的核心资源，包括 MR 物理和 PET 专业知识、多扫描仪序列和协议开发、图像数据质量控制和管理、研究合作以及进行 AD 神经影像研究的全球框架。成像核心由一个高度整合和协作的团队领导，包括 Arthur Toga（核心领导者）、 Judy Pa（联合负责人）、Meredith Braskie、Danny JJ Wang、Nasim Sheikh-Bahaei 和 Paul Thompson 共同提供血管、功能和结构成像及其分析方面的专业知识 3T 和 7T MRI 以及 PET 我们提出了 5 个具体目标，为所有 ADRC 提供成像框架。项目；对所有成像数据进行高质量控制；开发超高场7T MRI；协助PET方案制定和质量控制并进行教育和培训；总而言之，这些目标将为南加州大学 ADRC 的统一科学服务。血管对阿尔茨海默病的贡献主题：危险因素、神经血管和代谢机制，和降低风险。