Training for the Multiscale and Multimodal Analysis of Biomarkers in Alzheimer's Disease

阿尔茨海默病生物标志物的多尺度和多模式分析培训

• 批准号: 10162462
• 负责人: ARTHUR W TOGA
• 金额: $ 32.12万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10162462
• 关键词: Alzheimer' s Disease; Biological Markers; Training; multimodality

PROJECT SUMMARY/ABSTRACT Recognizing the critical need for a broad range of expertise in biomarker analysis at several levels of analysis, we propose a unique postdoctoral training program titled “Training for the Multiscale and Multimodal Analysis of Biomarkers in Alzheimer's Disease” (AD). USC is home to leading experts who utilize biomarkers in their work investigating AD through a myriad of methods and analyses. Drawing from USC's eminent resources and expertise, this proposal will focus on preparing investigators for independent research careers in the multiscale and multimodal analysis of biomarkers in AD, by integrating molecular and cellular methods, imaging tools and informatics, quantitative methods for clinical trials research, and large scale population analyses. Our proposed training program draws preceptors and faculty from six schools, departments, institutes, and centers at USC, fulfilling these methodological areas of expertise: Mark and Mary Stevens Neuroimaging and Informatics Institute (INI) in the Keck School of Medicine; Department of Biomedical Engineering (BME) in the Viterbi School of Engineering; Zilkha Neurogenetic Institute (ZNI) in the Keck School of Medicine; Department of Psychology in the Dana and David Dornsife College of Letters, Arts and Sciences; Leonard D. Schaeffer Center for Health Policy and Economics, a unique collaboration between the USC Sol Price School of Public Policy and School of Pharmacy; and Leonard Davis School of Gerontology. Trainees will complete coursework, lab rotations, and career development activities, such as seminar series, instruction for problem solving, communication, time management, and leadership skills, and instruction and training in grant writing. Trainees will become conversant in all thematic areas and will be able to effectively collaborate outside of their own particular area of expertise. Specifically, the USC Training for the Multiscale and Multimodal Analysis of Biomarkers in AD will aim to: equip trainees with a combination of skills to conduct multiscale and multimodal analyses of biomarkers in AD by providing tailored, didactic research education opportunities to further the research potential of trainees; facilitate eminent research in the multiscale and multimodal analysis of biomarkers in AD by trainees, including the development of research ideas, execution of research projects, and dissemination of research findings; establish among trainees a collaborative and multidisciplinary team approach to advance research in the multiscale and multimodal analysis of biomarkers in AD; and successfully transition trainees to independent research careers, including securing their own research funding.

项目概要/摘要 认识到在多个分析层面上对生物标志物分析的广泛专业知识的迫切需求， 我们提出了一个独特的博士后培训计划，名为“多尺度和多模态分析培训” 阿尔茨海默病生物标志物”（AD）是在其研究中使用生物标志物的领先专家的所在地。 通过利用南加州大学的丰富资源和分析的多种方法和分析来研究 AD。 专业知识，该提案将侧重于为研究人员在多尺度的独立研究生涯中做好准备 通过整合分子和细胞方法、成像工具和技术，对 AD 生物标志物进行多模式分析 信息学、临床试验研究的定量方法以及大规模人群分析。 培训计划吸引了来自南加州大学六个学院、系、研究所和中心的导师和教员， 满足这些方法论领域的专业知识：Mark 和 Mary Stevens 神经影像学和信息学 凯克医学院研究所 (INI)；维特比生物医学工程系 (BME) 凯克医学院工程学院；Zilkha 神经遗传学研究所 (ZNI)； 达纳和大卫·多恩西夫文学、艺术与科学学院心理学； 卫生政策与经济中心，南加州大学索尔普莱斯公立学院之间的独特合作 政策和药学院；以及伦纳德·戴维斯老年学学院的学员将完成课程， 实验室轮换和职业发展活动，例如研讨会系列、解决问题的指导、 沟通、时间管理和领导技能，以及资助实习生的指导和培训。 将熟悉所有主题领域，并能够在自己的领域之外进行有效的合作 具体来说，南加州大学的多尺度和多模式分析培训。 AD 中的生物标志物旨在： 为学员提供进行多尺度和多模式的综合技能 通过提供量身定制的教学研究教育机会来分析 AD 中的生物标志物，以进一步促进 受训者的研究潜力；促进多尺度和多模式分析的杰出研究 学员在 AD 中的生物标志物，包括研究想法的发展、研究项目的执行，以及 传播研究成果；在受训者中建立一个协作的多学科团队 成功推进 AD 生物标志物多尺度、多模式分析研究的方法； 将学员过渡到独立研究职业，包括确保自己的研究经费。