Training for the Multiscale and Multimodal Analysis of Biomarkers in Alzheimer's Disease

阿尔茨海默病生物标志物的多尺度和多模式分析培训

• 批准号: 10436893
• 负责人: ARTHUR W TOGA
• 金额: $ 24.13万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10436893
• 关键词: Alzheimer' s Disease; Biological Markers; Training; multimodality; Alzheimer' s Disease; Biological Markers; Training; multimodality

PROJECT SUMMARY/ABSTRACT Recognizing the critical need for a broad range of expertise in biomarker analysis at several levels of analysis, we propose a unique postdoctoral training program titled “Training for the Multiscale and Multimodal Analysis of Biomarkers in Alzheimer's Disease” (AD). USC is home to leading experts who utilize biomarkers in their work investigating AD through a myriad of methods and analyses. Drawing from USC's eminent resources and expertise, this proposal will focus on preparing investigators for independent research careers in the multiscale and multimodal analysis of biomarkers in AD, by integrating molecular and cellular methods, imaging tools and informatics, quantitative methods for clinical trials research, and large scale population analyses. Our proposed training program draws preceptors and faculty from six schools, departments, institutes, and centers at USC, fulfilling these methodological areas of expertise: Mark and Mary Stevens Neuroimaging and Informatics Institute (INI) in the Keck School of Medicine; Department of Biomedical Engineering (BME) in the Viterbi School of Engineering; Zilkha Neurogenetic Institute (ZNI) in the Keck School of Medicine; Department of Psychology in the Dana and David Dornsife College of Letters, Arts and Sciences; Leonard D. Schaeffer Center for Health Policy and Economics, a unique collaboration between the USC Sol Price School of Public Policy and School of Pharmacy; and Leonard Davis School of Gerontology. Trainees will complete coursework, lab rotations, and career development activities, such as seminar series, instruction for problem solving, communication, time management, and leadership skills, and instruction and training in grant writing. Trainees will become conversant in all thematic areas and will be able to effectively collaborate outside of their own particular area of expertise. Specifically, the USC Training for the Multiscale and Multimodal Analysis of Biomarkers in AD will aim to: equip trainees with a combination of skills to conduct multiscale and multimodal analyses of biomarkers in AD by providing tailored, didactic research education opportunities to further the research potential of trainees; facilitate eminent research in the multiscale and multimodal analysis of biomarkers in AD by trainees, including the development of research ideas, execution of research projects, and dissemination of research findings; establish among trainees a collaborative and multidisciplinary team approach to advance research in the multiscale and multimodal analysis of biomarkers in AD; and successfully transition trainees to independent research careers, including securing their own research funding.

项目摘要/摘要 认识到在几个分析级别的生物标志物分析方面对广泛专业知识的批判性需求， 我们提出了一项独特的博士后培训计划，标题为“多尺度和多模式分析的培训 阿尔茨海默氏病中的生物标志物”（AD）。南加州大学是利用生物标志物的领先专家的家园 通过无数方法和分析来调查广告的工作。从南加州大学的著名资源和 专业知识，该提案将着重于为多阶段独立研究职业的研究人员做好准备 通过整合分子和细胞方法，成像工具和 信息信息，临床试验研究的定量方法以及大规模的人群分析。我们提出的 培训计划吸引了来自USC的六所学校，部门，学院和中心的教职员工， 满足这些方法论领域的专业知识：马克和玛丽·史蒂文斯神经影像学和信息学 凯克医学院的研究所（INI）； Viterbi的生物医学工程系（BME） 工程学院；凯克医学院的Zilkha神经遗传学研究所（ZNI）；部门 Dana和David Dornsife学院的心理学，艺术和科学学院；伦纳德·D·沙弗（Leonard D. Schaeffer） 卫生政策与经济中心，这是USC Sol Price Price School之间的独特合作 政策和药学院；和伦纳德·戴维斯（Leonard Davis）老年学院。学员将完成课程工作， 实验室轮换和职业发展活动，例如开创性系列，解决问题的指导， 沟通，时间管理和领导能力，赠款写作中的指导和培训。学员 将在所有主题领域变得熟悉，并能够在自己的之外有效合作 特定的专业领域。具体而言，用于多尺度和多模式分析的USC培训 广告中的生物标志物的目的是：为受训者提供多种技能来进行多尺度和多模式 通过提供量身定制的教学研究教育机会来进一步促进广告中的生物标志物的分析 学员的研究潜力；促进在多尺度和多模式分析中的知名研究 受训者在广告中的生物标志物，包括研究思想的发展，研究项目的执行以及 研究结果的传播；在学员中建立一个协作和多学科团队 进步在AD中生物标志物的多模式分析和多模式分析的方法；并成功 过渡到独立研究职业，包括获得自己的研究资金。