Social Processes in Adolescent Anorexia Nervosa

青少年神经性厌食症的社会过程

基本信息

批准号：
10574406
负责人：
Carrie Justine McAdams
金额：
$ 27.06万
依托单位：
UT SOUTHWESTERN MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-12-21 至 2024-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10574406
关键词：
Acute Adolescence Adolescent Adult Age Anorexia Nervosa Behavior Behavior assessment Behavioral Belief Binge Eating Body Image Body Weight Body Weight decreased Brain Child Clinical Clinical Treatment Clinical assessments Cognition Cognitive Complex Computers Data Decision Making Development Disease Disease remission Eating Eating Behavior Eating Disorders Emotional Enrollment Environmental Impact Evaluation Evidence based treatment Family member Food Future Image Impaired cognition Impairment Individual Informal Social Control Knowledge Maintenance Measures Mediating Medical center Mental disorders Neuropsychology Nutritional Outcome Participant Patient Recruitments Patients Pediatric Hospitals Persons Philadelphia Pilot Projects Predisposition Process Psychopathology Questionnaires Recovery Relapse Sampling Self Assessment Self Concept Self Direction Self-Examination Site Social Behavior Social Controls Social Environment Social Interaction Social Perception Social Processes Structure Supervision Symptoms Time Translational Research Trust Weight Woman Work adolescent patient brain based clinical care clinical implementation cohort design follow-up improved neural neural circuit neurobehavioral neuroimaging programs response serial imaging severe mental illness social social metrics sustained recovery verbal virtual virtual assessment young adult young woman

项目摘要

PROJECT SUMMARY Eating disorders are serious mental illnesses with few effective evidence-based treatments and there is little mechanistic understanding of the neuropsychological impairments underlie both illness and recovery. We have previously identified differences in the neural circuits that process social behaviors in both adolescent and adult women recovering from anorexia nervosa. However, a better understanding of the relationships between social perceptions and clinical symptoms requires understanding this illness in individuals early in their course of the disease and examination of these processes over time as recovery progresses. This pilot exploratory project will examine adolescent women seeking treatment for anorexia nervosa both cross-sectionally and longitudinally. Comparison data from age-matched healthy controls will be collected. To maximize data, computer administered behavioral versions of well-characterized neuroimaging tasks assessing self-concept and social decisions will be utilized, allowing the entire study to be completed virtually. Two sites will recruit participants: Children’s Medical Center Eating Disorder Program at UTSW and the Children’s Hospital of Philadelphia (CHOP). The ability to conduct virtual assessments and tasks allows inclusion of 120 adolescent women (60 with anorexia nervosa and 60 healthy controls) at three time points (baseline, 3 months, and 6 months), in the short time frame of an R21. Aim 1 of this exploratory pilot project evaluates cognitive differences in self-concept while Aim 2 examines behavioral differences in social interactions. Within each aim, the social metrics obtained will be evaluated with regard to group differences and their relation to current clinical symptoms. An exploratory hypothesis within each aim will consider whether changes in clinical state are related to social metrics. At the conclusion of this pilot project, we will have a better understanding of which components of self-concept and social decisions differ in adolescents with anorexia nervosa and how these constructs are related to psychopathology.

项目摘要饮食失调是严重的精神疾病，几乎没有有效的循证治疗，几乎没有对神经心理学障碍的机械理解是疾病和康复的基础。我们有先前确定的在青少年和成人中处理社会行为的神经回路的差异妇女从厌食症中康复。但是，更好地理解社会之间的关系感知和临床症状需要在他们的早期中了解个体的这种疾病随着恢复的进展，疾病和对这些过程的检查。这个飞行员探索项目将考试青少年在横截面和纵向上寻求治疗厌食症的妇女。将收集来自年龄匹配的健康对照组的比较数据。为了最大化数据，计算机管理评估自我概念和社会决策的良好特征神经影像学任务的行为版本将被利用，允许整个研究实际上完成。两个站点将招募参与者：儿童 UTSW的医疗中心饮食失调计划和费城儿童医院（CHOP）。这进行虚拟评估和任务的能力允许包括120名青少年妇女（60名患有厌食症的妇女在短时间内，在三个时间点（基线，3个月和6个月）处于神经和60个健康对照） R21。该探索性试点项目的目标1评估了自我概念的认知差异，而目标2 考试在社会互动中的行为差异。在每个目标中，获得的社会指标将是评估了群体差异及其与当前临床症状的关系。探索性每个目标中的假设将考虑临床状态的变化是否与社会指标有关。在结论这个试点项目，我们将更好地了解自我概念的哪些组成部分具有厌食症的青少年的社会决策以及这些结构与心理病理学。