Social Processes in Adolescent Anorexia Nervosa

青少年神经性厌食症的社会过程

基本信息

批准号：
10574406
负责人：
Carrie Justine McAdams
金额：
$ 27.06万
依托单位：
UT SOUTHWESTERN MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-12-21 至 2024-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10574406
关键词：
Acute Adolescence Adolescent Adult Age Anorexia Nervosa Behavior Behavior assessment Behavioral Belief Binge Eating Body Image Body Weight Body Weight decreased Brain Child Clinical Clinical Treatment Clinical assessments Cognition Cognitive Complex Computers Data Decision Making Development Disease Disease remission Eating Eating Behavior Eating Disorders Emotional Enrollment Environmental Impact Evaluation Evidence based treatment Family member Food Future Image Impaired cognition Impairment Individual Informal Social Control Knowledge Maintenance Measures Mediating Medical center Mental disorders Neuropsychology Nutritional Outcome Participant Patient Recruitments Patients Pediatric Hospitals Persons Philadelphia Pilot Projects Predisposition Process Psychopathology Questionnaires Recovery Relapse Sampling Self Assessment Self Concept Self Direction Self-Examination Site Social Behavior Social Controls Social Environment Social Interaction Social Perception Social Processes Structure Supervision Symptoms Time Translational Research Trust Weight Woman Work adolescent patient brain based clinical care clinical implementation cohort design follow-up improved neural neural circuit neurobehavioral neuroimaging programs response serial imaging severe mental illness social social metrics sustained recovery verbal virtual virtual assessment young adult young woman

项目摘要

PROJECT SUMMARY Eating disorders are serious mental illnesses with few effective evidence-based treatments and there is little mechanistic understanding of the neuropsychological impairments underlie both illness and recovery. We have previously identified differences in the neural circuits that process social behaviors in both adolescent and adult women recovering from anorexia nervosa. However, a better understanding of the relationships between social perceptions and clinical symptoms requires understanding this illness in individuals early in their course of the disease and examination of these processes over time as recovery progresses. This pilot exploratory project will examine adolescent women seeking treatment for anorexia nervosa both cross-sectionally and longitudinally. Comparison data from age-matched healthy controls will be collected. To maximize data, computer administered behavioral versions of well-characterized neuroimaging tasks assessing self-concept and social decisions will be utilized, allowing the entire study to be completed virtually. Two sites will recruit participants: Children’s Medical Center Eating Disorder Program at UTSW and the Children’s Hospital of Philadelphia (CHOP). The ability to conduct virtual assessments and tasks allows inclusion of 120 adolescent women (60 with anorexia nervosa and 60 healthy controls) at three time points (baseline, 3 months, and 6 months), in the short time frame of an R21. Aim 1 of this exploratory pilot project evaluates cognitive differences in self-concept while Aim 2 examines behavioral differences in social interactions. Within each aim, the social metrics obtained will be evaluated with regard to group differences and their relation to current clinical symptoms. An exploratory hypothesis within each aim will consider whether changes in clinical state are related to social metrics. At the conclusion of this pilot project, we will have a better understanding of which components of self-concept and social decisions differ in adolescents with anorexia nervosa and how these constructs are related to psychopathology.

项目概要饮食失调是严重的精神疾病，几乎没有有效的基于证据的治疗方法，而且几乎没有我们对疾病和康复背后的神经心理损伤的机制有了解。先前发现青少年和成人处理社会行为的神经回路存在差异然而，从神经性厌食症中恢复的女性对社会之间的关系有更好的了解。认知和临床症状需要在疾病早期就了解个体的这种疾病随着恢复的进展，该试点探索项目将随着时间的推移对这些过程进行检查。对寻求神经性厌食症治疗的青春期女性进行横向和纵向检查。为了最大限度地利用计算机管理的数据，将收集年龄匹配的健康对照的比较数据。评估自我概念和社会决策的明确神经影像任务的行为版本将可以利用，使整个研究可以虚拟完成，两个地点将招募参与者：儿童研究中心。 UTSW 和费城儿童医院 (CHOP) 医疗中心饮食失调项目。进行虚拟评估和任务的能力允许纳入 120 名青春期女性（其中 60 名患有厌食症） 60 名健康对照）在三个时间点（基线、3 个月和 6 个月），在短时间内该探索性试点项目的 R21 目标 1 评估自我概念的认知差异，而目标 2 在每个目标中检查社交互动中的行为差异，获得的社交指标将是评估组差异及其与当前临床症状的关系。每个目标中的假设将考虑临床状态的变化是否与社会指标相关。通过这个试点项目的结束，我们将更好地了解自我概念的哪些组成部分和患有神经性厌食症的青少年的社会决策有所不同，以及这些结构如何与精神病理学。