Self and Other Perception in Eating Disorders

饮食失调中的自我和他人感知

基本信息

批准号：
9925251
负责人：
Carrie Justine McAdams
金额：
$ 62.78万
依托单位：
UT SOUTHWESTERN MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-07-25 至 2022-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9925251
关键词：
3-Dimensional Adult Affect Affective Anorexia Nervosa Anterior Anxiety Behavior Behavioral Belief Binge Eating Biological Markers Body Image Body Size Brain Bulimia Caloric Restriction Characteristics Clinical Cognitive Computer Models Data Development Disease Dorsal Eating Behavior Eating Disorders Economics Evaluation Exposure to Female Food Functional Magnetic Resonance Imaging Functional disorder Goals Individual Insula of Reil Interview Maintenance Measures Medial Mediating Mental Depression Methods Modeling Modernization Moods Neurobiology Pathogenesis Pathologic Patient Self-Report Patients Perception Persons Play Population Prefrontal Cortex Process Recovery Relapse Self Perception Self-Examination Series Shapes Social Behavior Social Environment Social Identification Social Interaction Social Values Societies Stimulus Symptoms Testing Thinness Trust Ventral Striatum Woman Women&apos s Group associated symptom base behavior measurement behavioral response causal model cognitive testing feeding food restriction innovation interest mortality network models neural circuit neuroeconomics novel strategies nutrition prevent purge relating to nervous system response self esteem severe mental illness social social norm trait

项目摘要

PROJECT SUMMARY Eating disorders (EDs) are serious mental illnesses afflicting approximately 5% of women. Anorexia nervosa (AN) is an ED that includes distortions of body shape and size and restriction of calories resulting in insufficient nutrition. Bulimia nervosa (BN) is an ED defined by an over-valuation of a thin body size which leads to dysfunctional eating behaviors, including restriction, binge eating, and purging. Both diseases are defined by altered beliefs about oneself, including problems of self-perception (body image distortions) and self-esteem. Previously, we have found neurobiological differences related to self-perception (medial prefrontal cortex and precuneus) and other-perception (temporoparietal junctions) and social self-evaluations (dorsal anterior cingulate, insula, medial prefrontal cortex) in EDs. Here, we will conduct a detailed analysis of self and other perception in a population of 40 women with AN, 40 women with BN, and 40 healthy women, using a series of complementary functional magnetic resonance imaging (fMRI) tasks in concert with clinical interviews, cognitive assessments, and self-report measures. The key goal of this project is to understand the neurobiological circuitry that mediates the core disturbances related to self-perception in EDs. Four different fMRI tasks have been included that evaluate complementary components of self and other perception. The Self-Tagging task assesses self-perception independent of social evaluations. The Social Identity with Values Task assesses self-perception and perspective-taking in the context of socially-defined values. The Affective Trust Game examines how a specific relationship with another individual develops, by measuring behavioral and neural responses during a series of economic interactions with a specific other person. The Affective Ultimatum game examines how behavior, neural activations, and moods change as subjects play a game that includes shifts of society, created with monetary exchanges. This game will allow a neural, mechanistic examination for a pathological trait believed to be related to pathogenesis of BN: disordered eating behaviors in BN are associated with exposure to different social norms such as the “thin-ideal” for female shape/size. In addition, three of these tasks consider differences for both positive and negative self-relevant stimuli, allowing us to evaluate how valence might contribute to neurobiological dysfunctions in self and other perception in EDs. We will use dynamic causal modeling (DCM), a method to examine the timing, directionality, and interactions occurring between different neural regions, building a network model of how dysfunctions in self-knowledge contribute to EDs. Core symptoms in adult EDs including feeding symptoms, body preoccupations, self-esteem, anxiety, and depression will be correlated with differences in the self/other neural circuitry. At conclusion of this study, we will have a biomarker understanding of the neurocircuitry for self/other perception and how these differences may contribute to the pathophysiology of EDs.

项目概要饮食失调 (ED) 是一种严重的精神疾病，困扰着大约 5% 的女性神经性厌食症。 (AN) 是一种 ED，包括身体形状和尺寸的扭曲以及卡路里的限制，导致摄入不足神经性贪食症 (BN) 是一种 ED，其定义是对瘦身尺寸的高估，从而导致功能失调的饮食行为，包括限制、暴食和清除。对自己的信念改变，包括自我认知（身体形象扭曲）和自尊问题。之前，我们发现了与自我感知相关的神经生物学差异（内侧前额叶皮层和楔前叶）和其他感知（颞顶交界处）和社会自我评价（背前叶 ED中的扣带回、岛叶、内侧前额叶皮质）在这里，我们将对自我和他人进行详细分析。使用一系列方法，对 40 名 AN 女性、40 名 BN 女性和 40 名健康女性进行了认知调查与临床访谈、认知能力相结合的补充功能磁共振成像（fMRI）任务该项目的主要目标是了解神经生物学回路。调解与 ED 自我感知相关的核心干扰已被研究为四种不同的功能磁共振成像任务。包括评估自我和其他感知的互补成分。自我标记任务评估。独立于社会评价的自我认知任务评估自我认知。以及在社会定义的价值观背景下的观点采择，情感信任游戏考察了如何通过测量一段时间内的行为和神经反应，与另一个人建立特定的关系情感最后通牒博弈考察了与特定其他人的一系列经济互动。当受试者玩游戏时，行为、神经激活和情绪都会发生变化，其中包括社会的转变、创造这个游戏将允许对所认为的病理特征进行神经、机械检查。与 BN 的发病机制相关：BN 的饮食失调行为与暴露于不同的环境有关。社会规范，例如女性体形/尺寸的“理想瘦身” 此外，其中三项任务考虑了差异。对于积极和消极的自我相关刺激，使我们能够评估效价如何有助于 ED 中自我和其他感知的神经生物学功能障碍我们将使用动态因果模型（DCM），一种检查不同神经区域之间发生的时间、方向性和相互作用的方法，建立一个网络模型，了解自我认识功能障碍如何导致成人 ED 的核心症状。包括进食症状、身体关注点、自尊、焦虑和抑郁都与自我/其他神经回路的差异在这项研究结束时，我们将对生物标志物有一个了解。自我/他人感知的神经回路以及这些差异如何影响病理生理学急诊室数量。