Self and Other Perception in Eating Disorders

饮食失调中的自我和他人感知

• 批准号: 9395238
• 负责人: Carrie Justine McAdams
• 金额: $ 70.62万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-25 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9395238
• 关键词: Adult; Affect; Affective; Anorexia Nervosa; Anterior; Anxiety; Behavior; Behavioral; Belief; Binge Eating; Biological Markers; Body Image; Body Size; Brain; Bulimia; Caloric Restriction; Characteristics; Clinical; Cognitive; Computer Simulation; Data; Development; Disease; Dorsal; Eating Behavior; Eating Disorders; Economics; Evaluation; Exposure to; Female; Food; Functional Magnetic Resonance Imaging; Functional disorder; Goals; Individual; Insula of Reil; Interview; Maintenance; Measures; Medial; Mediating; Mental Depression; Mental disorders; Methods; Modeling; Modernization; Moods; Neurobiology; Pathogenesis; Pathologic; Patient Self-Report; Patients; Perception; Persons; Play; Population; Prefrontal Cortex; Process; Recovery; Relapse; Self Perception; Self-Examination; Series; Shapes; Social Behavior; Social Environment; Social Identification; Social Interaction; Social Values; Societies; Stimulus; Symptoms; Testing; Thinness; Trust; Ventral Striatum; Woman; Women' s Group; associated symptom; base; behavior measurement; behavioral response; causal model; cognitive testing; feeding; food restriction; innovation; interest; mortality; network models; neural circuit; neuroeconomics; novel strategies; nutrition; prevent; purge; relating to nervous system; response; self esteem; severe mental illness; social; social norm; trait

PROJECT SUMMARY Eating disorders (EDs) are serious mental illnesses afflicting approximately 5% of women. Anorexia nervosa (AN) is an ED that includes distortions of body shape and size and restriction of calories resulting in insufficient nutrition. Bulimia nervosa (BN) is an ED defined by an over-valuation of a thin body size which leads to dysfunctional eating behaviors, including restriction, binge eating, and purging. Both diseases are defined by altered beliefs about oneself, including problems of self-perception (body image distortions) and self-esteem. Previously, we have found neurobiological differences related to self-perception (medial prefrontal cortex and precuneus) and other-perception (temporoparietal junctions) and social self-evaluations (dorsal anterior cingulate, insula, medial prefrontal cortex) in EDs. Here, we will conduct a detailed analysis of self and other perception in a population of 40 women with AN, 40 women with BN, and 40 healthy women, using a series of complementary functional magnetic resonance imaging (fMRI) tasks in concert with clinical interviews, cognitive assessments, and self-report measures. The key goal of this project is to understand the neurobiological circuitry that mediates the core disturbances related to self-perception in EDs. Four different fMRI tasks have been included that evaluate complementary components of self and other perception. The Self-Tagging task assesses self-perception independent of social evaluations. The Social Identity with Values Task assesses self-perception and perspective-taking in the context of socially-defined values. The Affective Trust Game examines how a specific relationship with another individual develops, by measuring behavioral and neural responses during a series of economic interactions with a specific other person. The Affective Ultimatum game examines how behavior, neural activations, and moods change as subjects play a game that includes shifts of society, created with monetary exchanges. This game will allow a neural, mechanistic examination for a pathological trait believed to be related to pathogenesis of BN: disordered eating behaviors in BN are associated with exposure to different social norms such as the “thin-ideal” for female shape/size. In addition, three of these tasks consider differences for both positive and negative self-relevant stimuli, allowing us to evaluate how valence might contribute to neurobiological dysfunctions in self and other perception in EDs. We will use dynamic causal modeling (DCM), a method to examine the timing, directionality, and interactions occurring between different neural regions, building a network model of how dysfunctions in self-knowledge contribute to EDs. Core symptoms in adult EDs including feeding symptoms, body preoccupations, self-esteem, anxiety, and depression will be correlated with differences in the self/other neural circuitry. At conclusion of this study, we will have a biomarker understanding of the neurocircuitry for self/other perception and how these differences may contribute to the pathophysiology of EDs.

项目摘要 饮食失调（EDS）是严重的精神疾病，大约有5％的女性。厌食症 （an）是一种急诊 营养。贪食症神经（BN）是由薄体大小的过度评估定义的 功能失调的饮食行为，包括限制，暴饮暴食和清洗。两种疾病均定义 改变自己的信念，包括自我感知问题（身体形象扭曲）和自尊。 以前，我们发现神经生物学差异与自我感知有关（内侧前额叶皮层和 前后）和其他感受（颞叶结合）和社会自我评估（背侧前方 Eds中的扣子，岛状，中间的前额叶皮层）。在这里，我们将对自我和其他人进行详细的分析 使用一系列的40名女性，40名女性和40名健康妇女的人口的感知，使用一系列 与临床访谈，认知能力共同实用的磁共振成像（fMRI）任务 评估和自我报告措施。该项目的关键目标是了解神经生物学电路 这介导了与ED中的自我感知有关的核心干扰。四个不同的fMRI任务已经 包括评估自我和其他知觉的完整组成部分。自我标记的任务评估 自我感知独立于社会评估。具有价值任务评估的社会身份自我认知 并在社会定义的价值观的背景下进行观点。情感信任游戏考试如何 通过测量在 与特定其他人的一系列经济互动。情感最后通游戏考试如何 行为，神经激活和情绪随着受试者的玩法而改变，包括社会转变，创造 进行货币交流。该游戏将允许对被认为的病理特征进行神经机械检查 与BN的发病机理有关：BN中的饮食行为无序与暴露有关 社会规范，例如女性形状/大小的“薄理想”。此外，其中三个任务考虑差异 对于积极和负面的自我相关刺激，使我们能够评估价如何有助于 自我和ED中其他感知的神经生物学功能障碍。我们将使用动态因果建模（DCM）， 一种检查时间，方向性和相互作用的方法发生在不同的神经区域之间， 建立一个网络模型，以了解自我知识中的功能障碍如何促进ED。成人ED中的核心症状 包括喂食症状，身体的敬意，自尊，焦虑和抑郁症将与 自我/其他神经电路的差异。在本研究的结尾，我们将有一个生物标志物的理解 自我/其他感知的神经循环系统以及这些差异如何有助于病理生理学 eds。